Date of Report (Date of earliest event reported): April 17, 2024

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Securities registered pursuant to Section 12(b) of the Act:

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As previously disclosed, Akebia Therapeutics, Inc. (the “Company”) is party to an Agreement for the Provision of a Loan Facility (the “Loan Agreement”), dated January 29, 2024 (the “Closing Date”), with Kreos Capital VII (UK) Limited, which are funds and accounts managed by BlackRock Inc. The Loan Agreement provides for a senior secured term loan facility in the aggregate principal amount of up to $55.0 million, subject to certain customary conditions (the “Term Loan Facility”). The Loan Agreement provided the Company access to an initial tranche of $37.0 million, which was funded on the Closing Date. In addition to the initial tranche, the Term Loan Facility included additional tranches available as follows: $8.0 million available in a single draw through December 31, 2024 (the “Tranche B Loan”), and $10.0 million available in a single draw through December 31, 2024 (the “Tranche C Loan”). On April 17, 2024, the Company elected to drawdown the Tranche B Loan and net proceeds of $7.5 million were received on April 19, 2024, after deducting debt issuance costs, fees, and expenses. Immediately following this $8.0 million drawdown, $10.0 million of borrowing capacity under the Tranche C Loan remained available under the Loan Agreement, subject to the terms and conditions set forth therein.

The foregoing description of the Loan Agreement is qualified in its entirety by reference to the full text of the Loan Agreement which was filed as Exhibit 10.102 to the Annual Report on Form 10-K for the fiscal year ended December 31, 2023, filed by the Company on March 14, 2024.

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.