Exhibit 99.1

 

Genmab Announces Proposed Private Offering of Senior Secured Notes and Senior Unsecured Notes and Syndication of New Senior Secured Term Loan Facility

Media Release

COPENHAGEN, Denmark; November 10, 2025

Genmab A/S (Nasdaq: GMAB) (“Genmab”) announced today that it and its wholly owned subsidiary Genmab Finance LLC (“Genmab Finance”) intend to offer, subject to market and other conditions, $1.5 billion of senior secured notes due 2032 (the “Secured Notes”) and $1.0 billion of senior unsecured notes due 2033 (the “Unsecured Notes,” and together with the Secured Notes, the “Notes”).

Genmab also launched the syndication of a new $2.0 billion senior secured term loan “B” facility, which term loan “B” facility is in addition to a $1.0 billion senior secured term loan “A” facility and $500 million senior secured revolving credit facility (collectively, the “New Credit Facilities”) that Genmab previously syndicated to certain lenders as part of the financing for the pending acquisition (the “Acquisition”) of Merus N.V. (“Merus”).

Genmab intends to use the net proceeds from this offering of the Notes, together with borrowings under the New Credit Facilities and cash on hand, to fund the consideration payable in connection with the Acquisition of Merus and related fees and expenses in connection with the Acquisition, the borrowings under the New Credit Facilities and the issuance of the Notes.

Prior to the Acquisition closing, the Notes and the related guarantees from Genmab subsidiaries will be secured solely by segregated securities accounts of Genmab in which the gross proceeds of the Notes will be held. Following the purchase of all Merus common shares tendered in the previously announced tender offer by Genmab, the Secured Notes will be secured by a first priority security interest in certain assets of Genmab and its subsidiaries that will guarantee the obligations under the New Credit Facilities, in accordance with certain customary practices in the relevant jurisdictions, and subject to certain thresholds, exceptions and permitted liens. The Secured Notes will be unconditionally guaranteed on a senior secured basis and the Unsecured Notes will be unconditionally guaranteed on a senior unsecured basis by certain subsidiaries of Genmab that will guarantee the obligations under the New Credit Facilities.

The indentures governing the Notes are expected to contain customary covenants that, among other things, restrict, with certain exceptions, the ability of each of Genmab and its subsidiaries to incur additional debt, pay dividends, make certain other restricted payments, incur debt secured by liens, dispose of assets, engage in consolidations and mergers or sell or transfer all or substantially all of its assets.

The Notes will not be registered under the Securities Act of 1933, as amended (the “Securities Act”), or any state or other securities laws and may not be offered or sold in the United States absent an effective registration statement or an applicable exemption from the registration requirements of or in a transaction not subject to the Securities Act and any state or other applicable securities laws. Accordingly, the offering of the Notes is available only to persons who are either (1) reasonably believed to be “qualified institutional buyers” as defined in Rule 144A under the Securities Act or (2) non-U.S. persons outside the United States pursuant to Regulation S under the Securities Act. The Notes will be subject to restrictions on transferability and resale and may not be transferred or resold except in compliance with the registration requirements of the Securities Act or pursuant to an exemption therefrom and in compliance with any state or other applicable securities laws.

 

Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark		Tel: +45 7020 2728 www.genmab.com		Media Release no. 22 Page 1 CVR no. 2102 3884 LEI Code 529900MTJPDPE4MHJ122

 

Genmab Announces Proposed Private Offering of Senior Secured Notes and Senior Unsecured Notes and Syndication of New Senior Secured Term Loan Facility

This announcement shall not constitute an offer to sell or a solicitation of an offer to purchase any securities and shall not constitute an offer, solicitation or sale in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful. The offering of the Notes may be made only by means of an offering memorandum.

Contact:

Marisol Peron, Senior Vice President, Global Communications & Corporate Affairs

T: +1 609 524 0065; E:mmp@genmab.com

Andrew Carlsen, Vice President, Head of Investor Relations

T: +45 3377 9558; E:acn@genmab.com

Forward-looking Statements

In this announcement, we make statements concerning our expectations, beliefs, plans, objectives, goals, strategies, and future events or performance, including, but not limited to, the statements about the proposed offering of Notes, our intention to issue the Notes and the expected use of proceeds. Genmab cautions investors that any forward-looking statements or projections made by Genmab, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described in Genmab’s filings with the SEC, including those included in Genmab’s most recent Annual Report on Form 20-F, which is available at www.genmab.com and www.sec.gov. Genmab is providing the information in this announcement as of this date, and Genmab does not undertake any obligation to update any forward-looking statements as a result of new information, future events or otherwise.

Genmab A/S and/or its subsidiaries own the following trademarks: Genmab®; the Y-shaped Genmab logo®; Genmab in combination with the Y-shaped Genmab logo®; HuMax®; DuoBody®; HexaBody®; DuoHexaBody®, HexElect® and KYSO®.

 

Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark		Tel: +45 7020 2728 www.genmab.com		Media Release no. 22 Page 2 CVR no. 2102 3884 LEI Code 529900MTJPDPE4MHJ122

Exhibit 99.2

 

Genmab Provides Certain Information Disclosed in Connection with Proposed Private Offering of Senior Secured Notes and Senior Unsecured Notes

Media Release

COPENHAGEN, Denmark; November 10, 2025

Genmab A/S (“Genmab”) announced on November 10, 2025, that it and its wholly owned subsidiary Genmab Finance LLC intend to offer, subject to market and other conditions, $1.5 billion of senior secured notes due 2032 (the “Secured Notes”) and $1.0 billion of senior unsecured notes due 2033 (the “Unsecured Notes,” and together with the Secured Notes, the “Notes”). Genmab also launched the syndication of a new $2.0 billion senior secured term loan “B” facility, which term loan “B” facility is in addition to a $1.0 billion senior secured term loan “A” facility and $500 million senior secured revolving credit facility (collectively, the “New Credit Facilities”) that Genmab previously syndicated to certain lenders as part of the financing for the pending acquisition (the “Acquisition”) of Merus N.V. (“Merus”).

In connection with the proposed offering of the Notes, Genmab is providing potential investors with a preliminary offering memorandum, dated November 10, 2025 (the “Preliminary Offering Memorandum”). The Preliminary Offering Memorandum contains (i) certain information not previously disclosed by Genmab, attached as Exhibit A to this Company Announcement; (ii) unaudited pro forma condensed combined financial information giving effect to the Acquisition of Merus, the borrowings under the New Credit Facilities and the issuance of the Notes as of and for the nine months ended September 30, 2025 and for the year ended December 31, 2024, attached as Exhibit B to this Company Announcement; and (iii) the audited consolidated financial statements of Genmab as of and for the years ended December 31, 2024, 2023 and 2022 and the related notes thereto, originally prepared in Danish Kroner and retranslated into United States Dollars for all periods presented, attached as Exhibit C to this Company Announcement.

This Company Announcement, including Exhibit A, Exhibit B and Exhibit C, does not constitute an offer to sell, or a solicitation of an offer to buy, any security. No offer, solicitation, or sale will be made in any jurisdiction in which such an offer, solicitation, or sale would be unlawful. The Notes will not be registered under the Securities Act of 1933, as amended, or the securities laws of any state or other jurisdiction, and, unless so registered, may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.

Contact:

Marisol Peron, Senior Vice President, Global Communications & Corporate Affairs

T: +1 609 524 0065; E:mmp@genmab.com

Andrew Carlsen, Vice President, Head of Investor Relations

T: +45 3377 9558; E:acn@genmab.com

Forward-looking Statements

In this announcement, we make statements concerning our expectations, beliefs, plans, objectives, goals, strategies, and future events or performance, including, but not limited to, the statements about the proposed offering of Notes and our intention to issue the Notes. Genmab cautions investors that any forward-looking statements or projections made by Genmab, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described in Genmab’s filings with the SEC, including those included in Genmab’s most recent Annual Report on Form 20-F, which is available at www.genmab.com and www.sec.gov. Genmab is providing the information in this Company Announcement as of this date, and Genmab does not undertake any obligation to update any forward- looking statements as a result of new information, future events or otherwise.

 

Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark		Tel: +45 7020 2728 www.genmab.com		Media Release no. 23 Page 1 CVR no. 2102 3884 LEI Code 529900MTJPDPE4MHJ122

 

Genmab Provides Certain Information Disclosed in Connection with Proposed Private Offering of Senior Secured Notes and Senior Unsecured Notes

Genmab A/S and/or its subsidiaries own the following trademarks: Genmab®; the Y-shaped Genmab logo®; Genmab in combination with the Y-shaped Genmab logo®; HuMax®; DuoBody®; HexaBody®; DuoHexaBody®, HexElect® and KYSO®.

 

Genmab A/S Carl Jacobsens Vej 30 2500 Valby, Denmark		Tel: +45 7020 2728 www.genmab.com		Media Release no. 23 Page 2 CVR no. 2102 3884 LEI Code 529900MTJPDPE4MHJ122

Exhibit 99.3

EXHIBIT A

EXCERPTS FROM THE PRELIMINARY OFFERING MEMORANDUM

 

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Risks Related to the Acquisition

The pending Acquisition may not be completed on the currently contemplated timeline or terms, or at all.

The consummation of the Acquisition is subject to the satisfaction or waiver of certain conditions. Satisfaction of a number of the conditions is not within our control, and it is possible that such conditions may prevent or delay or otherwise materially adversely affect our ability to complete the Acquisition. These conditions include (i) the expiration or termination of the relevant waiting period (as it may be extended) under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and the rules and regulations promulgated thereunder, (ii) a ‘no further questions’ response following submission of a briefing paper to the UK Competition and Markets Authority (the “UK CMA”), if this is the most recent response from the UK CMA as at the date all other conditions to the Offer are satisfied or, alternatively, clearance from the UK CMA following the submission of a notice to the CMA in the prescribed form as contemplated by Section 96 of the Enterprise Act 2002 in relation to the Offer, (iii) the valid tendering of a sufficient number of Merus common shares and (iv) adoption of resolutions by shareholders of Merus at an extraordinary meeting convened for the purpose of approving certain transactions related to the Offer, including the Back-End Transactions. Neither we nor Merus can provide assurance that the conditions to completing the Acquisition will be satisfied or waived, and accordingly, that the Acquisition will be completed on the timeline that the parties anticipate or at all. If any condition to the Acquisition is not satisfied, it could delay or prevent the Acquisition from occurring, which could negatively impact us and our growth prospects.

 

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We may not realize the anticipated benefits from the pending Acquisition.

The Acquisition involves the combination of two companies that currently operate as independent companies. While we and Merus will continue to operate independently until the Acquisition Closing Date, the success of the Acquisition will depend, in part, on our ability to realize the anticipated benefits from successfully combining our and Merus’ businesses after closing. We plan on devoting substantial management attention and resources to integrating our and Merus’ businesses so that we can fully realize the anticipated benefits of the Acquisition. Nonetheless, the acquired Merus business, including petosemtamab, may not be successful, may require greater resources and investments than originally anticipated or may result in the assumption of unknown or contingent liabilities, which could have an adverse effect on us or our results of operations.

Potential difficulties we may encounter following closing include the following:

 

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the inability to successfully combine our and Merus’ businesses in a manner that permits us to realize the anticipated benefits of the Acquisition in the timeframe currently anticipated, or at all;

 

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the failure to integrate internal systems, programs and internal controls, or applying different accounting policies, assumptions or judgments to Merus’ operational results than Merus applied in the past;

 

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effectively and efficiently integrating information technology and other systems;

 

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issues not discovered as part of the transactional due diligence process or unanticipated liabilities or contingencies of Merus, including employment or severance-related obligations under applicable law or other benefits arrangements, claims by or amounts owed to vendors or other commercial disputes, cyber incidents and information technology failures or delays, matters related to data privacy, data localization and the handling of personally identifiable information, and other unknown or contingent liabilities;

 

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preserving the important licensing, marketing, and other commercial relationships of Merus;

 

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the complexities associated with managing the combined company;

 

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the failure to retain key employees of either of the two companies who may be difficult to replace;

 

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the disruption of each company’s ongoing businesses or inconsistencies in services, standards, controls, procedures and policies;

 

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potential unknown liabilities and unforeseen increased expenses, delays or regulatory conditions associated with the Acquisition; and

 

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performance shortfalls at one or both of the two companies as a result of the diversion of management’s attention caused by completing the Acquisition and integrating our and Merus’ operations.

Any of these risks could adversely affect our ability to maintain relationships with collaboration partners, vendors, employees and other commercial relationships or adversely affect our or Merus’ future operational results. As a result, the anticipated benefits of the Acquisition may not be realized or at all or may take longer to realize or cost more than expected, which could adversely affect our business, financial condition, results of operations and growth prospects. In addition, changes in laws and regulations could adversely impact our business, financial condition, results of operations and growth prospects after the Acquisition.

The pendency of the Acquisition could adversely affect our and/or Merus’ businesses and operations.

In connection with the pending Acquisition, some collaboration partners, vendors or other parties with commercial relationships with either of us or Merus may delay or defer decisions, which could adversely affect the revenues, earnings, cash flows and expenses of us or Merus, regardless of whether the Acquisition is completed.

 

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In addition, due to operating covenants in the Transaction Agreement, Merus may be unable (without our prior written consent), during the pendency of the Acquisition, to pursue strategic transactions, undertake significant capital projects or otherwise pursue other actions outside the ordinary course, even if such actions would prove beneficial.

We expect to incur material expenses related to the Acquisition.

We expect to incur material expenses in connection with the Acquisition and the subsequent integration of the business, operations, practices, policies and procedures of Merus. These additional expenses could have an adverse effect on us or our results of operations. While we have assumed that a certain level of transaction and integration expenses would be incurred, there are a number of factors beyond our control that could affect the total amount or the timing of integration expenses. Many of the expenses that will be incurred, by their nature, are difficult to estimate accurately at the present time.

The Transaction Agreement and related documents may be amended or modified without your consent.

Between the time of the issuance of the notes and the consummation of the Acquisition, the parties to the Transaction Agreement may agree to modify or waive the terms or conditions of such documents without noteholder consent. The terms of the notes will not preclude the parties to the Transaction Agreement from making certain changes to the terms of the Acquisition or from waiving certain conditions to the Acquisition, which may adversely affect your investment in the notes.

Genmab’s ability to realize the anticipated benefits of the Acquisition will depend on its ability to effectively conduct clinical development of, obtain regulatory approvals for, and profitably commercialize, petosemtamab.

We may fail to realize the anticipated benefits of the Acquisition if we are unable to successfully develop, obtain regulatory approval for, and commercialize petosemtamab on the currently anticipated timeline, for all of the currently anticipated therapeutic indications, or at all.

While petosemtamab delivered positive data in certain HNSCC indications in prior Phase I/II trials, there is no assurance that the currently ongoing Phase III trials will ultimately demonstrate the efficacy of petosemtamab in those indications at a level that will be sufficient to obtain regulatory approval. A number of companies in the pharmaceutical, biopharmaceutical and biotechnology industries have suffered significant setbacks in advanced clinical trials even after obtaining promising results in earlier trials, and we cannot be certain that we will not face similar setbacks with petosemtamab.

In addition, while petosemtamab has received BTD from the FDA with respect to two HNSCC indications, this designation does not assure ultimate approval by the FDA. BTD is a process designed to expedite the development and review of drugs that are intended to treat a serious condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapy on a clinically significant endpoint. Drugs that receive BTD are eligible for certain procedural benefits as part of the FDA review process, including more frequent meetings with FDA staff to discuss the drug’s development plan and ensure collection of appropriate data needed to support drug approval, more frequent written communication from FDA staff, rolling review of BLA or NDA submissions, intensive guidance on an efficient drug development program, and organizational commitment involving senior managers. BTD does not, however, change the scientific and medical standard for approval or the quality of evidence necessary to support approval. As a result, applications for product candidates granted expedited review or BTD designation may be ultimately denied based on trial data, trial design or other factors.

Furthermore, even though the available data from petosemtamab Phase I/II trials in certain HNSCC indications may seem stronger in certain respects than data for certain alternative therapies, there is no completed head-to-head trial that actually compared the safety and efficacy of petosemtamab with any alternative therapy as part of the same investigational setting.

 

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Separate clinical trials for alternative therapies may differ in trial design and duration, patient population, treatment protocols and investigators and other important factors, making it difficult to compare data across trials or to draw reliable conclusions from such cross-trial comparisons. It is possible that petosemtamab may turn out not to be superior to alternative therapies in the currently ongoing Phase III trials in HNSCC.

Even if we can successfully progress the clinical development of petosemtamab and obtain the anticipated marketing approvals, we may not be able to commercialize it on the currently anticipated timeline or at all, or to realize its expected revenue potential. For more information about the risks involved in clinical development, regulatory approval and commercialization of new products generally, please see “—Risks Related to Product Development.” Our ability to realize petosemtamab’s potential is also subject to all of the other risks affecting our business described in this “Risk Factors” section.

Genmab’s and Merus’ actual financial positions and results of operations may differ materially from the unaudited pro forma condensed combined financial information included in this offering memorandum.

The unaudited pro forma condensed combined financial information contained in this offering memorandum is presented for illustrative purposes only and may differ materially from what Genmab’s actual financial position or results of operations would have been had the Acquisition been completed on the dates indicated. The unaudited pro forma condensed combined financial information has been derived from the audited and unaudited historical financial statements of Genmab and Merus and certain adjustments and assumptions have been made regarding the combined company after giving effect to the Transactions. The assets and liabilities of Merus have been measured at fair value based on various preliminary estimates using assumptions that Genmab management believes are reasonable utilizing information currently available. The process for estimating the fair value of acquired assets and assumed liabilities requires the use of judgment in determining the appropriate assumptions and estimates. These estimates may be revised as additional information becomes available and as additional analyses are performed. Differences between preliminary estimates in the unaudited pro forma condensed combined financial information and the final acquisition accounting will occur and could have a material impact on the unaudited pro forma condensed combined financial information and the combined company’s financial position and future results of operations.

In addition, the assumptions used in preparing the unaudited pro forma condensed combined financial information may not prove to be accurate, and other factors may affect Genmab’s financial condition or results of operations following the completion of the Acquisition. Furthermore, while Genmab’s financial statements are prepared in accordance with IFRS, Merus’ financial statements have historically been prepared in accordance with U.S. GAAP. We have provided adjustments to present these reported results on a basis consistent with Genmab’s accounting policies under IFRS; however, there may be additional differences in the accounting standards that were not captured in such adjustments which would have altered the results.

 

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CAPITALIZATION

The following table sets forth our cash and cash equivalents and marketable securities and capitalization as of September 30, 2025 on (i) an actual basis and (ii) on an as adjusted basis after giving effect to the Transactions. The information in this table should be read in conjunction with “Use of Proceeds,” “Unaudited Pro Forma Condensed Combined Financial Information” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” as well as the historical consolidated financial statements included in this offering memorandum. For purposes of this presentation, the as adjusted debt amounts are presented at their full principal amounts, without giving effect to any capitalization of debt issuance costs under IFRS.

 

		As of September 30, 2025
		Actual				As Adjusted
		($ in millions)
Cash and cash equivalents and marketable securities(1)		$	3,411			$	1,153
Total long-term debt:
New Revolving Facility(2)			—				—
Existing Revolving Facility(3)			—				—
Term Loan A Facility(4)			—				1,000
Term Loan B Facility(4)			—				2,000
Secured Notes offered hereby(5)			—				1,500
Unsecured Notes offered hereby(5)			—				1,000
Total long-term debt, including current portion			—				5,500
Total shareholders’ equity			5,751				5,751
Total capitalization		$	5,751			$	11,251

(1)

Approximately $2,895 million of cash and cash equivalents and marketable securities is expected to be used as a source of funds in connection with the Acquisition. The actual amount of cash and cash equivalents and marketable securities that will be used as a source of funds in connection with the Acquisition will vary depending on, among other things, our cash balance on the Acquisition Closing Date, transaction fees and expenses and the Acquisition Closing Date. The as adjusted column reflects Merus cash and cash equivalents and marketable securities of $637 million as of September 30, 2025 as presented under IFRS, which involved a reclassification of $181 million of Merus non-current marketable securities under U.S. GAAP to other investments under IFRS. See Note 2 in “Unaudited Pro Forma Condensed Combined Financial Information” for further information. Assumes the Notes are issued at par.

(2)

The New Revolving Facility is expected to provide for commitments for $500 million of revolving borrowings, which would constitute secured indebtedness when drawn. The Issuers expect the New Revolving Facility to be undrawn at the closing of the Acquisition. See “Description of Certain Other Indebtedness.”

(3)

Our Existing Credit Agreement provides for $300 million in commitments of revolving borrowings. As of September 30, 2025, there were $0 million in borrowings under our Existing Credit Agreement. We expect to terminate the existing revolving credit facility prior to or concurrently with the closing of the Acquisition. See “Description of Certain Other Indebtedness.”

(4)

Concurrently with the closing of the Acquisition, the Issuers expect to enter into the Term Loan A Facility and the Term Loan B Facility, as further described in “Summary—The Transactions—Financing Transactions”, each of which will be fully drawn at the closing of the Acquisition. “Description of Certain Other Indebtedness.”

(5)	Assumes the Notes are issued at par.

 

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MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following discussion and analysis of Genmab’s financial condition and results of operations covers periods prior to the consummation of the Acquisition, except for the subsections “Acquisition of Merus,” “Key Components of Our Results and Related Trends—Impact of the Acquisition of Merus” and “Liquidity and Capital Resources—Liquidity and Capital Resources Following the Acquisition”. Accordingly, the discussion and analysis of historical periods do not reflect the impact that the Acquisition will have on us. You should read the following discussion of Genmab’s financial condition and results of operations in conjunction with the Genmab Consolidated Financial Statements and the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum. This discussion contains forward-looking statements and involves numerous risks and uncertainties, including, but not limited to, those described in the “Forward-Looking Statements” ands “Risk Factors” sections of this offering memorandum. Actual results may differ materially from those contained in any forward-looking statements. Unless otherwise indicated or the context otherwise requires, references in this management’s discussion and analysis of financial condition and results of operations to “we,” “us,” “our,” “Genmab” and the “Company” refer to Genmab and its consolidated subsidiaries over which Genmab has control before giving effect to the consummation of the Acquisition.

Overview

Genmab is an international biotechnology company with a core purpose of improving the lives of patients with innovative and differentiated antibody therapeutics. For more than 25 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. Genmab’s antibody technology platforms have given rise to eight commercialised products and a pipeline of novel antibody-based products and product candidates designed to address medical needs and improve treatment outcomes for patients with cancer and other serious diseases. Our pipeline includes both wholly owned and partnered programs, with several compounds in late-stage clinical development. Our goal in building our pipeline is to bring medicines to market ourselves in geographic areas where we believe we will be able to maximize their value. By 2030, our vision is to transform the lives of people with cancer and other serious diseases with knock-your-socks-off antibody medicines®.

Since Genmab’s founding in 1999 we have been dedicated to creating innovative and differentiated antibody therapeutics, initially as a R&D innovation powerhouse out-licensing novel candidates to large cap pharma partners, including Janssen, Roche, GSK and Novo Nordisk, for upfront, milestone and royalty payments. Early partnerships yielded six FDA-approved, commercialized, royalty-bearing products: DARZALEX, Kesimpta, TEPEZZA, RYBREVANT, TALVEY, and TECVAYLI. In full-year 2024, these products generated approximately $18 billion in aggregate partner net sales, providing a strong, recurring royalty revenue foundation for Genmab. Given the constantly evolving oncology landscape, our antibody platforms and our expertise and know-how in antibody development, we have shifted our model into a fully integrated biotech company through commercialization and co-commercialization of proprietary products such as EPKINLY and Tivdak in certain geographies, allowing Genmab to retain a greater share of the economic potential of these products. We are focused on the development of our proprietary, wholly owned pipeline, including through high potential growth opportunities such as our acquisition of ProfoundBio in 2024 and the Acquisition, which has resulted in a significant portfolio that incorporates the next wave of innovation in oncology indications with high medical needs.

Our current priorities are the commercial or late-stage programs epcoritamab and wholly owned Rina-S and acasunlimab. Epcoritamab, marketed as EPKINLY in the U.S. and Japan and as TEPKINLY outside of those territories, is being developed and commercialized in collaboration with AbbVie.

 

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Epcoritamab is the only bispecific antibody approved with a dual indication for the treatment of certain B-cell malignancies in the U.S., Europe and Japan. Rina-S entered Phase III clinical development for PROC in 2024 and EC in 2025, and acasunlimab entered Phase III clinical development for NSCLC in 2024.

The table below summarizes key data points on our six approved royalty products and our two approved proprietary products, respectively.

 

 

(1)	To the extent available and reported; RYBREVANT®, TECVAYLI® and TALVEY® are not owned products.

(2)	Remaining 10% of revenue attributable to milestones and reimbursements and licensing.

(3)	Source: For DARZALEX® and TECVAYLI® 2024 sales, J&J FY 2024 financial results; for KESIMPTA® 2024 sales, Novartis FY 2024 financial results; for TEPEZZA® 2024 sales, Amgen FY 2024 results; for TIVDAK® and EPKINLY® 2024 sales, GMAB FY 2024 presentation.

(4)	Exclusivity protection provided by Genmab patents (exp. 2031) and Novartis owned patents (exp. 2037). Royalties continue to be paid on all sales after patent expirations.

(5)	Co-commercialization collaboration.

(6)	U.S., European and Japanese patents for EPKINLY® and TIVDAK® do not begin to expire until the dates shown, however requests for patent term extensions have been filed for both which, if approved, would provide protection beyond the displayed end dates.

(7)	Includes $253M in EPKINLY® net product sales and $7M in TEPKINLY® royalties.

Innovation and Proprietary Technology Platform

Our portfolio includes five proprietary antibody technology platforms: (i) our DuoBody platform, which can be used for the creation and development of bispecific antibodies; (ii) our HexaBody platform, which can be used to increase the potential potency of antibodies through hexamerization; (iii) our DuoHexaBody platform, which enhances the potential potency of bispecific antibodies through hexamerization; (iv) our HexElect platform, which combines two HexaBody molecules to maximize potential potency while minimizing potential toxicity by more selective binding to desired target cells; and (v) our ADC platforms, acquired through the purchase of ProfoundBio in May 2024. Antibody products created with these technologies may be used in a wide variety of indications including cancer as well as autoimmune, central nervous system and infectious diseases. These platforms play a key role in building our product pipeline, enhancing our collaborations and generating revenue. We selectively enter into collaborations with other biotechnology and pharmaceutical companies that build our network in the biotechnology space and give us access to complementary novel technologies or products that move us closer to achieving our vision and fulfilling our core purpose.

 

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Our innovation and proprietary technology platforms are used in the pipelines of global pharmaceutical and biotechnology companies. These companies are running clinical development programs with antibodies created by Genmab or created using Genmab’s proprietary DuoBody bispecific antibody technology platform. The six approved medicines created by Genmab or that incorporate Genmab’s innovation or technology platforms are: daratumumab, marketed by J&J as DARZALEX (IV formulation) and DARZALEX FASPRO or DARZALEX SC (SC formulation), approved in the U.S., Europe, Japan and other territories for the treatment of certain indications of MM and AL amyloidosis; amivantamab, marketed in the U.S., Europe, Japan and other territories by J&J as RYBREVANT for the treatment of certain adult patients with locally-advanced or metastatic NSCLC with EGFR exon 20 insertion mutations; teclistamab, marketed in the U.S., Europe, Japan and other territories by J&J as TECVAYLI for certain indications of MM; talquetamab, marketed in the U.S., Europe, Japan and other territories by J&J as TALVEY for certain indications of MM; SC ofatumumab, marketed in the U.S., Europe, Japan and other territories as Kesimpta by Novartis for the treatment of RMS; and teprotumumab, marketed in the U.S. and Japan as TEPEZZA by Amgen for the treatment of TED. Under the agreements for these products we are entitled to certain royalties based on net sales and potential milestone payments.

For our proprietary commercial products EPKINLY and Tivdak, our commercialization rights and related revenues and expenses vary by jurisdiction as further described below:

 

•

EPKINLY collaboration with AbbVie. Genmab shares commercial responsibilities for epcoritamab, marketed as EPKINLY, with AbbVie in the U.S. and Japan, while AbbVie is responsible for global commercialization outside of the U.S. and Japan. We are the principal for net sales of epcoritamab in the U.S. and Japan and receive tiered royalties on remaining global sales outside these territories. We are entitled to tiered royalties between 22% and 26% on net sales for epcoritamab outside the U.S. and Japan, subject to certain royalty reductions. Except for these royalty-bearing sales, we share with AbbVie profits from the sale of epcoritamab on a 50:50 basis. We and AbbVie split 50:50 the development costs related to epcoritamab, while we will be responsible for 100% of the costs for the discovery research programs up to the stage at which AbbVie elects whether to participate in co-development and co-commercialization of a compound or licensed product.

 

•

Tivdak collaboration with Pfizer. Genmab is co-promoting tisotumab vedotin, marketed as Tivdak, in the U.S. with Pfizer, with Pfizer recording U.S. sales and Genmab receiving a 50% share of profit on such sales. Genmab is co-promoting tisotumab vedotin, marketed as Tivdak, in the U.S., and we lead commercial operational activities and record sales in Japan, where the product has been approved. Effective January 1, 2025, Genmab and Pfizer agreed to amend the Pfizer License and Collaboration Agreement (as defined herein) and the Tivdak Joint Commercialization Agreement (as defined herein), assigning Genmab sole responsibility for the development and commercialization of Tivdak for second line plus recurrent or metastatic cervical cancer in Europe and all other regions globally, excluding the U.S. and the China region. Pfizer will lead operational commercial activities in China, if and when approved in connection with the sublicense of its right to develop and commercialize Tivdak in China to Zai Lab, with a 50:50 profit split.

Our results of operations have been, and we expect them to continue to be, affected by our collaboration with J&J for the development and commercialization of daratumumab. Since inception, we have funded our operating requirements primarily through proceeds from equity financing and milestone payments and royalties from our collaboration partners. We expect to continue to fund a significant portion of our development expenses for our proprietary product candidates as well as our planned commercialization activities with funds received from royalties and milestone payments from our collaboration partners.

For a description of certain of our product and technology collaborations including relevant royalty tiers, milestones and expense sharing provisions, please refer to “Business of Genmab—Product and Technology Collaborations”.

 

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Acquisition of Merus

We announced the proposed Acquisition of Merus on September 29, 2025. Following the Back-End Closing Date, Merus will become our wholly owned subsidiary. The Acquisition, if consummated, will give us worldwide rights to Merus’ approved product, BIZENGRI (zenocutuzumab), as well as to its candidates in clinical development, including its lead product candidate, petosemtamab. In addition, we will acquire Merus’ Biclonics and Triclonics technology platforms. Petosemtamab is an investigational antibody-dependent cell-mediated cytotoxicity (ADCC)-enhanced Biclonics® for the potential treatment of solid tumors that is designed to bind to cancer stem cells expressing EGFR and LGR5.

We intend to continue the clinical development of petosemtamab in the LiGeR-HN1 Phase III clinical trial for the treatment of 1L PD-L1+ r/m HNSCC with pembrolizumab; the LiGeR-HN2 Phase III clinical trial for the treatment of 2/3L r/m HNSCC and the ongoing Phase I/II clinical trial in mCRC. We also intend to commence a Phase III clinical trial of petosemtamab in locally advanced HNSCC.

The FDA granted petosemtamab BTD in combination with pembrolizumab for the first-line treatment of adult patients with r/m PD-L1 positive HNSCC with CPS ≥ 1 in February 2025, and for the treatment of patients with r/m HNSCC whose disease has progressed following treatment with platinum based chemotherapy and an anti-PD-1 or anti-PD-L1 antibody. This designation followed receipt of FTD for petosemtamab for the treatment of patients with r/m HNSCC whose disease has progressed following treatment with platinum-based chemotherapy and an anti-programmed cell death protein 1 antibody announced in August 2023.

See “Summary—The Transactions—The Acquisition” for more information about the Acquisition, and “Business of Merus” for more information about Merus and petosemtamab.

Acquisition of ProfoundBio Inc.

On May 21, 2024, we completed the acquisition of all of the outstanding shares of ProfoundBio, resulting in ProfoundBio becoming a wholly owned subsidiary of Genmab. The acquisition of ProfoundBio gave us worldwide rights to three candidates in clinical development, including ProfoundBio’s lead drug candidate, Rina-S. In addition, we acquired ProfoundBio’s novel ADC technology platforms. Rina-S is a clinical-stage, FRa-targeted, TOPO1 ADC, currently in a Phase III clinical trial for the treatment of PROC. Based on the data from the ongoing Phase I/II clinical trial we intend to continue to broaden the development plans for Rina-S within ovarian cancer and other FRa-expressing solid tumors. In January 2024, the U.S. FDA granted FTD to Rina-S for the treatment of patients with FRa-expressing high-grade serous or endometrioid platinum-resistant ovarian cancer. In August 2025, the FDA granted BTD to Rina-S for the treatment of adult patients with recurrent or progressive endometrial cancer who have disease progression on or following prior treatment with a platinum-containing regimen and a PD-L1 therapy. A Phase III trial in endometrial cancer, RAINFOL-03, has been initiated.

See Note 5.5 in the Genmab Consolidated Financial Statements and Note 2 to the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum for additional details regarding our acquisition of ProfoundBio.

Key Components of Our Results and Related Trends

Impact of the Acquisition of Merus

We expect that, after consummation of the Acquisition, our research and development expenses, as well as our selling, general and administrative expenses, will increase in the short to medium term as compared to our own recent historical levels, and as compared to such historical expenses pro forma for the Acquisition as presented in our unaudited pro forma financial statements included elsewhere in this offering memorandum. We expect an increase in these expenses primarily as a result of our planned development and commercialization activities for petosemtamab.

 

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Following the Acquisition, we intend to expand Merus’ current development plan for petosemtamab in additional HNSCC settings and other potential tumor types. Such expanded development will involve increased research and development and selling, general and administrative expenses as we support related manufacturing, clinical trial activities, and commercialization activities. See “—Liquidity and Capital Resources—Liquidity.”

While we expect to record additional royalty revenues following the Acquisition because we will acquire zenocutuzumab from Merus, we do not expect such revenues to be material. Considering the costs of development of petosemtamab and other Merus product candidates, we expect to maintain positive operating earnings and positive cash flow generation driven by our royalty business and proprietary products.

In addition, we recorded acquisition-related costs in the nine months ended September 30, 2025 and expect to record acquisition-related costs in the year ending December 31, 2025 related to the Acquisition. We also expect to record integration-related charges related to the Acquisition in the years ending December 31, 2025 and December 31, 2026. Such acquisition and integration-related charges may be significant.

Revenues

Our revenues are currently comprised of royalties, milestone revenue, reimbursement revenue, collaboration revenue, license fees, and net product sales. Royalty revenue from licenses is based on third-party sales of licensed products. Milestone revenue is typically related to reaching particular stages in product development, regulatory approval or a certain level of net sales. Reimbursement revenue is mainly comprised of the reimbursement of certain research and development expenses related to the development work under our collaboration agreements. Collaboration revenue reflects profit sharing arrangements for the sale of commercial products by our collaboration partners. License fees are non-refundable, upfront fees for our intellectual property received from our collaboration partners. Net product sales represent sales of products when Genmab is determined to be the principal in sales to the end customers.

The majority of our revenue is recognized from our collaboration partners under our collaboration agreements. In particular, our ability to generate revenue significantly depends on the success of J&J’s continued ability to effectively maintain and grow sales of DARZALEX for its approved indications, expand its indications, and successfully compete with existing and potential new investigational agents and technologies that are currently being marketed or studied for the same indications as DARZALEX. In addition, the royalties payable by J&J are limited in time. Pursuant to the terms of the agreement, J&J’s obligation to pay royalties to us will expire on a country-by-country basis on the later of the date that is 13 years after the first sale of daratumumab in such country or upon the expiration or invalidation of the last-to-expire relevant Genmab patent covering daratumumab in such country. The first U.S., European and Japanese sales of daratumumab occurred in 2015, 2016 and 2017, respectively. We have issued patents and pending patent applications covering daratumumab in numerous jurisdictions, including patents issued in the U.S., Europe and Japan. J&J owns a separate patent portfolio related to the subcutaneous formulation of daratumumab used in DARZALEX FASPRO/DARZALEX SC, but a binding arbitration determined that we are not entitled to royalties based on these separate patents. Our issued U.S., European and Japanese patents covering daratumumab, after giving effect to issued U.S., European and Japanese PTEs and SPCs, expire in 2029, 2031 and begin to expire in 2030, respectively. Assuming constant underlying sales of DARZALEX, we expect that our royalties from sales of DARZALEX will begin to decline materially in 2029 following expiration of our U.S. patent rights on daratumumab. We have also received, and in the future may from time to time receive, revenues from milestones and other payments relating to our collaborations.

In addition to revenue recognized from our collaboration partners, we also record revenue for sales of our proprietary commercial products. Epcoritamab was approved by the FDA and Japan MHLW in May 2023 and September 2023, respectively, and is marketed in the U.S. and Japan under the tradename EPKINLY. Our net product sales are currently almost exclusively derived from EPKINLY.

 

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Tisotumab vedotin was approved by the FDA in September 2021, and is currently marketed in the U.S. as Tivdak. Pfizer records net product sales in the U.S. and shares 50% of the profit of such sales with us, and we record this profit share as collaboration revenue. Our ability to generate revenue from our proprietary commercial products, including EPKINLY and Tivdak, depends on the commercial potential of such products as well as our ability to successfully commercialize them.

Our ability to generate revenue from our proprietary and partnered product candidates depends on our and our collaboration partners’ ability to successfully complete clinical trials for our product candidates receive regulatory approvals, and effectively commercialize, all of which could impact the commercial potential of such products and our potential to receive milestone payments, royalties, net sales and other revenues for these products in the future.

For more information on our revenues, including for the breakdown of our revenues by type, collaboration partner and product, see Note 2.1 of the Genmab Consolidated Financial Statements and Note 3 of the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum.

Cost of Product Sales

Cost of product sales includes direct and indirect costs relating to the manufacture of inventory mainly from third-party providers of manufacturing as well as costs related to internal resources and distribution and logistics. Cost of product sales also includes product costs, royalty expense and profit-sharing amounts owed to collaboration partners for the sale of commercial products when Genmab is determined to be the principal in sales to end customers. For the year ended December 31, 2024 and the nine months ended September 30, 2025, the only profit-sharing amounts recorded as cost of product sales relate to 50:50 sharing of sales and related cost of product sales of EPKINLY in the U.S. and Japan pursuant to the collaboration agreement with AbbVie.

Research and Development Expenses

We are currently advancing our proprietary product candidates through clinical development and are conducting pre-clinical trials with respect to other programs. Developing product candidates is expensive, time-intensive and risky, and we expect our research and development expenses to increase over the next few years, particularly as we seek to advance our proprietary product candidates toward commercialization. Our research and development expenses include internal costs relating to our research and development departments, as well as external costs relating to trials performed by external suppliers and collaboration partners. Internal research and development expenses consist primarily of salaries and benefits for our research and development staff and related expenses, including expenses related to cash bonuses, warrant and restricted stock unit (“RSU”) programs as applicable to such personnel, costs of related facilities, equipment and other overhead expenses that have been determined to be directly attributable to research and development, costs associated with obtaining and maintaining patents for intellectual property, amortization of licenses and rights, amortization and impairment of intangible assets and depreciation and impairment of property and capital assets used to develop our product candidates.

Major components of the external costs are fees and other costs paid to CROs in conjunction with preclinical trials and the performance of clinical trials, milestone payments for in-licensed technology, as well as fees paid to CMOs in conjunction with the production of clinical compounds, drug substances and drugs. This includes (i) antibody clinical material for use in clinical trials and (ii) preparation for production of process validation batches for potential future regulatory submissions and related activities. These costs are expensed as incurred, because they do not qualify to be capitalized as inventory under IFRS Accounting Standards since the technical feasibility of the materials is not proven and no alternative use for them exists in the absence of marketing approval. Research and development expenses include amortization of intangible assets only in connection with licenses and rights we have acquired and capitalized. We do not capitalize intellectual property generated through our internal development activities. We expect to incur higher research and development expenses in future periods, including increasing costs for clinical trials and manufacturing as our proprietary product candidates advance in clinical development and we increase the number of product candidates under active clinical development.

 

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Our research and development expenses may vary substantially from period to period based on the timing of our research and development activities, including timing due to regulatory approvals and enrollment of patients in clinical trials. See “Liquidity and Capital Resources—Liquidity and Capital Resources Following the Acquisition” below.

Selling, General and Administrative Expenses

Our selling, general and administrative expenses consist primarily of wages and salaries for personnel other than research and development staff. Also included are expenses related to pre-launch commercialization activities, depreciation, amortization and impairment of property and equipment, to the extent such expenses are related to the administrative functions, and co-promotion expenses related to commercial sales of Tivdak in the U.S. in accordance with our Tivdak Joint Commercialization Agreement with Pfizer. Lastly, selling, general and administrative expenses include our 50% share of the aggregate costs incurred by us and AbbVie in relation to sales and commercialization of EPKINLY in the U.S. and Japan. We expect our selling, general and administrative expenses to increase over the next few years as we continue to expand our commercialization capabilities in a number of jurisdictions. Such expenses may also increase over time as a result of inflation and other factors.

Overhead expenses are allocated to research and development expenses or selling, general and administrative expenses based on the number of employees and their relevant functions. The Dutch Research and Development Act (“WBSO”) provides compensation for a part of research and development wages and other costs at our Utrecht facility through a reduction in payroll taxes in the Netherlands. WBSO grant amounts are offset against wages and salaries included in research and development expenses.

Our ongoing research and development and, increasingly, commercialization activities will require substantial amounts of capital and may not ultimately be successful. Over the next several years, we expect that we will continue to incur substantial selling, general and administrative expenses, primarily as a result of activities related to the continued development of our proprietary pipeline and developing our commercial capabilities. Our proprietary product candidates will require significant further development, financial resources and personnel to pursue and obtain regulatory approval and develop them into commercially viable products, if they are approved and commercialized at all. Our commitment of resources to the research and continued development of our product candidates and expansion of our proprietary pipeline will likely result in our selling, general and administrative expenses increasing and/or fluctuating as a result of such activities in future periods. We may also incur significant milestone payment obligations to certain of our licensors as our product candidates progress through clinical trials towards potential commercialization.

Acquisition and Integration Related Charges

In the year ended December 31, 2024, acquisition related charges comprised payments to holders of outstanding ProfoundBio equity awards related to post-combination services. The remaining expenses are integration related charges, which comprise professional fees incurred to assist with the integration of ProfoundBio into our operations post-acquisition. See Note 5.5 in the Genmab Consolidated Financial Statements and Note 2 in the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum for additional details regarding our acquisition of ProfoundBio.

 

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Results of Operations

Results of Operations for the Nine Months Ended September 30, 2025 and 2024

The following table sets forth our results of operations for the periods presented.

 

		Nine Months Ended September 30,
($ million)		2025				2024
Revenue		$	2,662			$	2,198
Cost of product sales			(157	)			(95	)
Research and development expenses			(1,080	)			(1,032	)
Selling, general and administrative expenses			(418	)			(370	)
Acquisition and integration related charges			—				(39	)
Total costs and operating expenses		$	(1,655	)		$	(1,536	)
Operating profit		$	1,007			$	662
Financial income			312				328
Financial expenses			(170	)			(181	)
Net profit before tax		$	1,149			$	809
Corporate tax			(217	)			(228	)
Net profit		$	932			$	581

Revenue

Genmab’s revenue was $2,662 million for the nine months ended September 30, 2025 compared to $2,198 million for the same period in 2024. The increase of $464 million, or 21%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our collaborations with J&J and Novartis, respectively, and increased EPKINLY net product sales. This increase was partly offset by reduced reimbursement revenue associated with Genmab assuming full control of development, as well as future commercialization, of the acasunlimab program, effective in the second half of 2024.

 

		Nine Months Ended September 30,
($ million)		2025								2024
Royalties		$	2,219				83	%		$	1,802				82	%
Reimbursement Revenue			43				2	%			121				6	%
Milestone Revenue			66				2	%			51				2	%
Collaboration Revenue			54				2	%			45				2	%
Net Product Sales			280				11	%			179				8	%
Total revenue		$	2,662				100	%		$	2,198				100	%

 

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Royalty revenue amounted to $2,219 million for the nine months ended September 30, 2025 compared to $1,802 million for the same period in 2024. The increase of $417 million, or 23%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our daratumumab collaboration with J&J and ofatumumab collaboration with Novartis. The table below summarizes Genmab’s royalty revenue by product.

 

		Nine Months Ended September 30,
($ million)		2025				2024
DARZALEX		$	1,744			$	1,442
Kesimpta			320				228
TEPEZZA			75				78
Other			80				54
Total royalties		$	2,219			$	1,802

DARZALEX

J&J’s net sales of DARZALEX were $10,448 million for the nine months ended September 30, 2025 compared to $8,586 million for the same period in 2024. The increase of $1,862 million, or 22%, was driven by market share gains in all regions.

Royalty revenue on net sales of DARZALEX was $1,744 million for the nine months ended September 30, 2025 compared to $1,442 million for the same period in 2024, an increase of $302 million. The percentage increase in royalties of 21% is in line with the percentage increase in the underlying net sales.

Kesimpta

Novartis’ net sales of Kesimpta were $3,198 million for the nine months ended September 30, 2025 compared to $2,274 million for the same period in 2024. The increase of $924 million, or 41%, was primarily driven by increased demand and strong access.

Royalty revenue on net sales of Kesimpta was $320 million for the nine months ended September 30, 2025 compared to $228 million for the same 2024, an increase of $92 million, or 40%, which is in line with the percentage increase in net sales.

TEPEZZA

Amgen’s net sales of TEPEZZA were $1,446 million for the nine months ended September 30, 2025 and $1,391 million for the same period in 2024. Royalty revenue on net sales of TEPEZZA was $75 million for the nine months ended September 30, 2025 compared to $78 million for the same period in 2024, a decrease of $3 million, or 4% which is in line with the slight reduction of net sales.

Other royalties

Other royalties consist of royalties from net sales of RYBREVANT, TECVAYLI, TALVEY and TEPKINLY.

J&J was granted U.S. FDA approval for RYBREVANT during the second quarter of 2021, and Genmab subsequently started recognizing royalties on net sales of RYBREVANT. Royalties were not material for the nine months ended September 30, 2025 or the nine months ended September 30, 2024.

J&J was granted conditional approval for TECVAYLI for the treatment of R/R multiple myeloma during the third quarter of 2022 in Europe and approval in the fourth quarter of 2022 in the U.S. Royalties were not material for the nine months ended September 30, 2025 or the nine months ended September 30, 2024.

 

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During the third quarter of 2023, J&J was granted approval in the U.S. and conditional approval in Europe for TALVEY for the treatment of relapsed or refractory multiple myeloma. Royalties were not material for the nine months ended September 30, 2025 or the nine months ended September 30, 2024.

The EC granted conditional marketing authorization for TEPKINLY as a monotherapy for the treatment of adult patients with relapsed or refractory DLBCL after two or more lines of systemic therapy during the third quarter of 2023. Royalties from AbbVie were not material for the nine months ended September 30, 2025 or the nine months ended September 30, 2024.

Royalty revenue fluctuations from period to period are driven by the level of product net sales and more specifically to DARZALEX, the contractual arrangement related to the annual currency hedge rate under our agreement with J&J, at which sales of DARZALEX for non-U.S. dollar denominated currencies are translated to U.S. dollars, Genmab’s share of J&J’s royalty payments to Halozyme in connection with SC product net sales and royalty deductions on net sales in countries and territories where there is no patent protection.

Reimbursement Revenue

Reimbursement revenue, mainly comprised of the reimbursement of certain research and development costs related to the development work under Genmab’s collaboration agreements, amounted to $43 million for the nine months ended September 30, 2025 and $121 million for the same period in 2024. The decrease of $78 million, or 64%, was primarily driven by Genmab assuming full control of development, as well as future commercialization, of the acasunlimab program, effective in the second half of 2024.

Milestone Revenue

Milestone revenue was $66 million for the nine months ended September 30, 2025 compared to $51 million for the same period in 2024, an increase of $15 million, or 29%, primarily driven by the following:

Nine Months Ended September 30, 2025 milestones:

 

•

AbbVie milestone of $30 million due to the acceptance for filing of a BLA by the FDA in the third indication of epcoritamab in the U.S.

 

•

Janssen milestones of $10 million due to the BLA approval for Talvey in China and $10 million due to the European Commission’s approval of a new indication of DARZALEX formulation as a monotherapy for the treatment of patients with smoldering multiple myeloma (“SMM”), and

 

•

Novo Nordisk milestone of $13 million due to the filing of a BLA in the U.S. for Mim8.

Nine Months Ended September 30, 2024 milestones:

 

•

AbbVie milestone of $50 million due to the acceptance for filing of a BLA by the FDA in the second indication of epcoritamab in the U.S.

Milestone revenue may fluctuate significantly from period to period due to both the timing of achievements and the varying amount of each individual milestone under our license and collaboration agreements.

Collaboration Revenue

Collaboration revenue, which reflects 50% of gross profit from net sales of Tivdak in the U.S. by Pfizer, was $54 million for the nine months ended September 30, 2025 compared to $45 million for the same period in 2024. The increase of $9 million, or 20%, primarily driven by an increase in net sales by Pfizer in the U.S. of Tivdak, which was approved in April 2024.

 

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Net Product Sales

Genmab’s net product sales include sales of EPKINLY in the U.S. and Japan and Tivdak in Japan and Germany. Global net product sales of EPKINLY/TEPKINLY were $333 million in the first nine months ended September 30, 2025 compared to $203 million for the same period in 2024, an increase of $130 million or 64%, driven by strong growth in 3L+ DLBCL and the expansion to address a second indication, 3L+ FL, which was approved in the U.S. in June 2024. Net product sales of EPKINLY in the U.S. and Japan recorded by Genmab were $272 million in the first nine months of 2025 compared to $179 million in the first nine months of 2024. EPKINLY was approved in the U.S. in May 2023 and in Japan in September 2023.

Net sales of TEPKINLY in territories where Genmab receives royalty revenue were $61 million in the first nine months ended September 30, 2025 compared to $24 million for the same period in 2024.

Net product sales of Tivdak by Genmab were $8 million in the first nine months ended September 30, 2025 with no net product sales for the same period in 2024. Tivdak was approved in Japan in May 2025 and became available for prescribing in Germany in September 2025.

Refer to Note 3 of the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum for further details about revenue.

Cost of Product Sales

Genmab recognized cost of product sales of $157 million for the nine months ended September 30, 2025 compared to $95 million for the same period in 2024. Cost of product sales includes product costs, royalty expense and profit-sharing amounts payable to AbbVie. The profit-sharing amount paid to AbbVie related to EPKINLY was $128 million for the nine months ended September 30, 2025 compared to $86 million for the same period in 2024.

Research and Development Expenses

Research and development expenses amounted to $1,080 million in the first nine months of 2025 compared to $1,032 million in the first nine months of 2024. The increase of $48 million, or 5%, was driven by the addition of ProfoundBio related research and development expenses, primarily Rina-S, and the increase in team members to support the continued expansion of our product portfolio. The acquisition of ProfoundBio occurred in the second quarter of 2024 and therefore there were minimal ProfoundBio related research and development expenses during the first nine months of 2024. These increases were partly offset by decreased research and development expenses related to Epcoritamab under our collaboration with AbbVie, primarily due to lower chemistry, manufacturing and controls (“CMC”) costs in the first nine months of 2025 compared to the first nine months of 2024.

Research and development expenses accounted for 72% of total research and development expenses & selling, general and administrative expenses in the first nine months of 2025 compared to 74% in the first nine months of 2024.

Selling, General and Administrative Expenses

Selling, general and administrative expenses were $418 million for the nine months ended September 30, 2025 compared to $370 million in the same period in 2024. The increase from the nine months ended September 30, 2024 to the same period in 2025 of $48 million, or 13%, was driven primarily by the expansion of Genmab’s global commercialization capabilities, primarily associated with the expansion of epcoritamab and investment in commercialization related activities related to the anticipated launch of Rina-S.

 

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Selling, general and administrative expenses accounted for 28% of total research and development expenses and selling, general and administration expenses for the nine months ended September 30, 2025 compared to 26% in the same period in 2024.

Acquisition and Integration Related Charges

Acquisition and integration related charges for the acquisition of ProfoundBio were $39 million in the first nine months of 2024. There were $0 million acquisition and integration related charges in the first nine months of 2025.

Refer to Note 5.5 of the Genmab Consolidated Financial Statements and Note 2 to the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum for further details about the acquisition of ProfoundBio.

Operating Profit

Operating profit was $1,007 million for the nine months ended September 30, 2025 compared to $662 million for the same period in 2024, an increase of $345 million, or 52%.

Financial Income and Expense

Financial income and expense was comprised of the following:

 

		Nine Months Ended September 30,
($ million)		2025				2024
Financial income:
Interest and other financial income		$	90			$	112
Gain on marketable securities			87				139
Gain on other investments, net			—				5
Foreign exchange rate gain			135				72
Total financial income		$	312			$	328
Financial expenses:
Interest and other financial expenses		$	(17	)		$	(10	)
Loss on marketable securities			(24	)			(131	)
Loss on other investments, net			(1	)			—
Foreign exchange rate loss			(128	)			(40	)
Total financial expenses		$	(170	)		$	(181	)
Net Financial Items		$	142			$	147

Interest and Other Financial Income

Interest and other financial income was $90 million for the nine months ended September 30, 2025 compared to $112 million for the same period in 2024. The decrease of $22 million, or 20%, from the nine months ended September 2024 to the same period in 2025 was primarily driven by lower average cash and cash equivalents and marketable securities as a result of the ProfoundBio acquisition in the second quarter of 2024, as well as lower interest rates on USD denominated marketable securities in the first nine months of 2025 compared to the first nine months of 2024.

 

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Foreign Exchange Rate Gains and Losses

Foreign exchange rate gain, net, which excludes foreign exchange rate movements on marketable securities, was $7 million in the first nine months of 2025 compared to foreign exchange rate gain, net of $32 million in the first nine months of 2024. The decrease in foreign exchange rate gain, net is primarily driven by a lower foreign exchange rate impact due to the change in functional currency of Genmab from DKK to USD on January 1, 2025.

Marketable Securities Gains and Losses

Gain on marketable securities, net was $63 million for the nine months ended September 30, 2025 compared to $8 million for the same period in 2024. The increase was primarily driven by the change in the functional currency of Genmab A/S effective January 1, 2025. As the majority of Genmab’s investment portfolio is denominated in U.S. dollars, these securities were adversely affected by the weakening of the USD against the DKK during the first nine months of 2024. In contrast, during the first nine months of 2025, Genmab’s DKK and EUR denominated securities benefited from the strengthening of those currencies against the USD, resulting in a higher overall gain on marketable securities.

Refer to Note 6 of the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum for further details regarding net financial items.

Corporate Tax

Corporate tax expense was $217 million for the nine months ended September 30, 2025 compared to $228 million for the same period in 2024. The decrease in corporate tax expense is primarily the result of Genmab’s lower estimated annual effective tax rate in the first nine months of 2025 of 18.9% compared to 28.1% in the first nine months of 2024.

Net Profit

Net profit for nine months ended September 30, 2025 was $932 million compared to $581 million for the same period in 2024. The changes in net profit between the periods were driven by the items described above.

Results of Operations for the Year Ended December 31, 2024 and 2023

The following table sets forth our results of operations for the periods presented.

 

		Year Ended December 31,
($ million)		2024				2023
Revenue		$	3,121			$	2,390
Cost of product sales			(143	)			(33	)
Research and development expenses			(1,414	)			(1,107	)
Selling, general and administrative expenses			(549	)			(478	)
Acquisition and integration related charges			(43	)			—
Total costs and operating expenses		$	(2,149	)		$	(1,618	)
Operating profit		$	972			$	772
Financial income			645				299
Financial expense			(291	)			(254	)
Net profit before tax		$	1,326			$	817
Corporate Tax			(193	)			(186	)
Net Profit		$	1,133			$	631

 

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Revenue

Genmab’s revenue was $3,121 million in 2024 compared to $2,390 million in 2023. The increase of $731 million, or 31%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our collaborations with J&J and Novartis, respectively. Increased EPKINLY net product sales, driven by a strong product launch in 2023 with a full year of net sales in 2024, also contributed to increased revenue in 2024.

 

		Year Ended December 31,
($ million)		2024								2023
Royalties		$	2,517				80	%		$	1,989				83	%
Reimbursement Revenue			144				5	%			124				5	%
Milestone Revenue			145				5	%			171				7	%
Collaboration Revenue			62				2	%			45				2	%
Net Product Sales			253				8	%			61				3	%
License Revenue			—				—	%			—				—	%
Total revenue		$	3,121				100	%		$	2,390				100	%

Royalties

Royalty revenue amounted to $2,517 million in 2024 compared to $1,989 million in 2023. The increase of $528 million, or 27%, was primarily driven by higher DARZALEX and Kesimpta royalties achieved under our daratumumab collaboration with J&J and ofatumumab collaboration with Novartis, respectively. The table below summarizes Genmab’s royalty revenue by product.

 

		Year Ended December 31,
($ million)		2024				2023
DARZALEX			2,019				1,635
Kesimpta			323				217
TEPEZZA			106				102
Other			69				35
Total royalties		$	2,517			$	1,989

DARZALEX

J&J’s net sales of DARZALEX were $11,670 million in 2024 compared to $9,744 million in 2023. The increase from 2023 to 2024 of $1,926 million, or 20%, was driven by share gains in all regions.

Royalty revenue on net sales of DARZALEX was $2,019 million in 2024 compared to $1,635 million in 2023, an increase of $384 million.

The percentage increase in royalties of 23% from 2023 to 2024 is higher than the percentage increase in the underlying net sales of 20% primarily due to a higher effective royalty rate for 2024 and other positive foreign exchange rate impacts, partially offset by the increase in Genmab’s Halozyme royalty reductions in connection with the increase in SC product net sales and an increase in royalty reductions on net sales in countries and territories where there is no Genmab patent coverage as well as lower average exchange rate between the USD and DKK in 2024. Under our license agreement with Janssen for DARZALEX, for purposes of calculating royalties due to Genmab, DARZALEX net sales for non-U.S. dollar denominated currencies are translated to U.S. dollars at a specified annual Currency Hedge Rate. This contractual arrangement is the driver for the other foreign exchange impacts discussed elsewhere in this offering memorandum.

 

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Kesimpta

Novartis’ net sales of Kesimpta were $3,224 million in 2024 compared to $2,171 million in 2023. The increase of $1,053 million from 2023 to 2024, or 49%, was primarily driven by increased demand and strong access.

Royalty revenue on net sales of Kesimpta was $323 million in 2024 compared to $217 million in 2023, an increase of $106 million, or 49%.

TEPEZZA

Amgen’s net sales of TEPEZZA were $1,851 million in 2024 compared to $1,771 million in 2023. Royalty revenue on net sales of TEPEZZA was $106 million in 2024 compared to $102 million in 2023, an increase of $4 million, or 4%.

Other royalties

Other royalties consist of royalties from net sales of RYBREVANT, TECVAYLI, TALVEY and TEPKINLY.

J&J was granted FDA approval for RYBREVANT during the second quarter of 2021, and Genmab subsequently started recognizing royalties on net sales of RYBREVANT. Royalties were not material for 2024 or 2023.

J&J was granted conditional approval for TECVAYLI for the treatment of relapsed or refractory multiple myeloma during the third quarter of 2022 in Europe and approval in the fourth quarter of 2022 in the U.S. Royalties were not material for 2024 or 2023.

During the third quarter of 2023, J&J was granted approval in the U.S. and conditional approval in Europe for TALVEY for the treatment of relapsed or refractory multiple myeloma. Royalties were not material for 2024 or 2023.

The EC granted conditional marketing authorization for TEPKINLY as a monotherapy for the treatment of adult patients with relapsed or refractory DLBCL after two or more lines of systemic therapy during the third quarter of 2023. Royalties from AbbVie, related to European net sales, were not material for 2024 or 2023.

Royalty revenue fluctuations from period to period are driven by the level of product net sales, foreign currency exchange rate movements and more specifically to DARZALEX, the contractual arrangement related to annual Currency Hedge Rate, Genmab’s share of J&J’s royalty payments to Halozyme in connection with SC product net sales and royalty deductions on net sales in countries and territories where there is no patent protection.

Reimbursement Revenue

Reimbursement revenue, mainly comprised of the reimbursement of certain research and development costs related to the development work under Genmab’s collaboration agreements, amounted to $144 million in 2024 compared to $124 million in 2023. The increase of $20 million, or 16%, from 2023 to 2024 was primarily driven by higher activities under our collaboration agreements with BioNTech for DuoBody-CD40x4-1BB and acasunlimab, prior to Genmab assuming full ownership, as well as by higher activities under our collaboration agreement with Pfizer for Tivdak.

 

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Milestone Revenue

Milestone revenue was $145 million in 2024 compared to $171 million in 2023, a decrease of $26 million, or 15%, primarily driven by the following:

2024 milestones:

 

•

Novartis milestone of $84 million (DKK 582 million) driven by worldwide net sales for Kesimpta, first exceeding $2.5 billion (DKK 17.4 billion) in 2024, and

 

•

AbbVie milestone of $50 million due to the acceptance for filing of a BLA by the U.S. FDA in the second indication of epcoritamab in the U.S.

2023 milestones:

 

•

AbbVie milestone of $50 million driven by the first commercial sale of EPKINLY in the U.S.,

 

•

AbbVie milestone of $30 million due to the acceptance of the marketing authorization application (MAA) filing by the EMA of the type II variation for marketing authorization of TEPKINLY,

 

•

AbbVie milestone of $25 million due to the first commercial sale of TEPKINLY in Europe, and

 

•

J&J milestone of $25 million related to the BLA approval in the U.S. for talquetamab.

Milestone revenue may fluctuate significantly from period to period due to both the timing of achievements and the varying amount of each individual milestone under our license and collaboration agreements.

Collaboration Revenue

Collaboration revenue, which reflects 50% of gross profit from net sales of Tivdak in the U.S. by Pfizer, was $62 million in 2024 compared to $45 million in 2023. The increase of $17 million, or 38%, from 2023 to 2024 was primarily driven by increased sales of Tivdak.

Net Product Sales

Global net sales of EPKINLY/TEPKINLY were $281 million in 2024. Net product sales in the U.S. and Japan by Genmab were $253 million in 2024 compared to $61 million in 2023. EPKINLY was approved in the U.S. in May 2023 and in Japan in September 2023.

Net sales of TEPKINLY in territories where Genmab receives royalty revenue were $28 million in 2024, with immaterial net sales in 2023 due to regulatory approvals in such territories not occurring until late 2023.

Refer to Note 2.1 of the Genmab Consolidated Financial Statements included in this offering memorandum for further details about revenue.

Cost of Product Sales

Genmab recognized cost of product sales of $143 million in 2024 compared to $33 million in 2023. Cost of product sales related to EPKINLY sales is primarily comprised of profit-sharing amounts payable to AbbVie of $122 million in 2024 compared to $28 million in 2023, as well as product costs. Aside from these items, there are no other costs included within cost of product sales.

Refer to Notes 2.3, 3.5 and 5.6 of the Genmab Consolidated Financial Statements in this offering memorandum for further details about cost of product sales.

 

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Research and Development Expenses

Research and development expenses amounted to $1,414 million in 2024 compared to $1,107 million in 2023. The increase from 2023 to 2024 of $307 million, or 28%, was driven by the increased and accelerated advancement of epcoritamab under our collaboration with AbbVie, the addition of ProfoundBio related research and development expenses, primarily Rina-S, advancement of acasunlimab and DuoBody- CD40x4-1BB under our collaboration with BioNTech, further progression of pipeline products, and the increase in team members to support the continued expansion of our product portfolio.

Research and development costs accounted for 72% of total research and development expenses and selling, general and administration expenses in 2024 compared to 70% in 2023.

The following table provides information regarding our research and development expenses for 2024 as compared to 2023.

 

		December 31,								Percentage Change
($ million)		2024				2023
Research(1)		$	310			$	219				42	%
Development and contract manufacturing(2)			516				337				53	%
Clinical(3)			478				476				—	%
Other(4)			110				75				47	%
Total research and development expenses		$	1,414			$	1,107				28	%

(1)

Research expenses include, among other things, personnel, occupancy and laboratory expenses, technology access fees associated with identification of new monoclonal antibodies (mAbs), expenses associated with the development of new proprietary technologies and research activities associated with our product candidates, such as in vitro and in vivo studies, translational research, and IND enabling toxicology studies.

(2)

Development and contract manufacturing expenses include personnel and occupancy expenses, external contract manufacturing costs for the scaleup and pre-approval manufacturing of drug product used in research and our clinical trials, costs for drug product supplied to our collaborators, costs related to preparation for the production of process validation batches to be used in potential future regulatory submissions, quality control and assurance activities, and storage and shipment of our product candidates.

(3)	Clinical expenses include personnel, travel, occupancy costs, and external clinical trial costs including contract research organizations (CROs), investigator fees, clinical site fees, contractors and regulatory activities associated with conducting human clinical trials.

(4)	Other research and development expenses primarily include share-based compensation, depreciation, amortization and impairment expenses.

 

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The following table shows third-party costs incurred for research, contract manufacturing of our product candidates and clinical and regulatory services for 2024 as compared to 2023. The table also presents unallocated costs and overhead consisting of third-party costs for our preclinical stage programs, personnel, facilities, and other indirect costs not directly charged to development programs.

 

		December 31,								Percentage Change
($ million)		2024				2023
Epcoritamab		$	414			$	192				116	%
Rina-S			46				—				N/A
Tisotumab vedotin			38				41				(7	)%
Acasunlimab			102				80				28	%
DuoBody-CD40x4-1BB			75				59				27	%
Other clinical stage programs			73				109				(33	)%
Total third-party costs for clinical stage programs		$	748			$	481				56	%
Preclinical projects			216				164				32	%
Personnel, unallocated costs and overhead			450				462				(3	)%
Total research and development expenses		$	1,414			$	1,107				28	%

Third-party costs for epcoritamab increased by $222 million, or 116%, in 2024 as compared to 2023, primarily due to the advancement and acceleration of the epcoritamab program under Genmab’s collaboration with AbbVie.

Third-party costs for Rina-S were $46 million in 2024. Rina-S was acquired through the acquisition of ProfoundBio in the second quarter of 2024.

Third-party costs for tisotumab vedotin decreased by $3 million, or 7%, in 2024 as compared to 2023, primarily due to the completion of certain clinical study activities in 2024.

Third-party costs for acasunlimab increased by $22 million, or 28%, in 2024 as compared to 2023, primarily due to the continued advancement of the program, which Genmab obtained sole ownership during the third quarter of 2024.

Third-party costs for DuoBody-CD40x4-1BB increased by $16 million, or 27%, in 2024 as compared to 2023, primarily due to the continued advancement and expansion of the program under Genmab’s collaboration with BioNTech.

Third-party costs for Genmab’s other clinical stage programs decreased by $36 million, or 33%, in 2024 as compared to 2023, primarily related to advancements of DuoBody-CD3xB7H4 and DuoBody-CD3xCD30 in 2024.

Research and development expenses related to our preclinical projects increased by $52 million, or 32%, in 2024 as compared to 2023, driven by the continued investment in new and existing preclinical programs. An IND was submitted for DuoBody-FAPaxDR4 and a CTA was submitted for GEN1078.

Personnel, unallocated costs and overhead decreased by $12 million, or 3%, in 2024 as compared to 2023, primarily due to travel costs, which were higher in 2023 due to the upcoming launch of EPKINLY in 2023. Our research and development full time equivalents increased from 1,541 at the end of 2023 to 1,886 at the end of 2024.

Refer to Note 2.3, 3.1, 3.2 and 5.5 of the Genmab Consolidated Financial Statements included in this offering memorandum for further details about staff costs, intangible assets, property and equipment and the acquisition of ProfoundBio.

 

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Selling, General and Administrative Expenses

Selling, general and administrative expenses were $549 million in 2024 compared to $478 million in 2023. The increase from 2023 to 2024 of $71 million, or 15%, was driven by the continued expansion of Genmab’s commercialization capabilities through the increase in team members to support the continued launch of EPKINLY in the U.S. and Japan in 2023, and the investment in Genmab’s broader organizational capabilities. Selling, general and administration expense growth has been moderating during 2024 reflecting a focus on driving efficiency. We continue to increase team members and commercial support in a strategic manner.

$263 million, or 48% of selling, general and administrative expenses in 2024 was related to compensation of Genmab team members associated with selling, general and administrative activities, as compared to $224 million, or 47% in 2023.

Refer to Note 2.3 and 3.2 for further details about staff costs and property and equipment.

Selling, general and administrative expenses accounted for 28% of total research and development expenses and selling, general and administration expenses in 2024 compared to 30% in 2023.

Acquisition and Integration Related Charges

Acquisition and integration related charges for the acquisition of ProfoundBio were $43 million in 2024 compared to $0 million acquisition and integration related charges for 2023 as there were no acquisitions during 2023.

Refer to Note 5.5 of the Genmab Consolidated Financial Statements included in this offering memorandum for further details about the acquisition of ProfoundBio.

Operating Profit

Operating profit was $972 million in 2024 compared to $772 million in 2023, an increase of $200 million, or 26%.

Financial Income and Expense

Financial income and expense was comprised of the following:

 

($ million)		2024				2023
Financial income:
Interest and other financial income			144				142
Gain on marketable securities			237				157
Gain on other investments			6				—
Foreign exchange rate gain			258				—
Total financial income			645				299
Financial expenses:
Interest and other financial expenses			(18	)			(10	)
Loss on marketable securities			(107	)			(174	)
Loss on other investments			—				(4	)
Foreign exchange rate loss			(166	)			(66	)
Total financial expenses			(291	)			(254	)
Net financial items			354				45

 

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Interest and Other Financial Income

Interest and other financial income was $144 million in 2024 compared to $142 million in 2023. The increase of $2 million, or 1% from 2023 to 2024, was primarily driven by the higher cash and cash equivalents and marketable securities in the first half of 2024 compared to 2023, almost entirely offset by lower cash and cash equivalents and marketable securities in the second half of 2024 compared to 2023 as a result of liquidating marketable securities and using cash to purchase ProfoundBio.

Foreign Exchange Rate Gains and Losses

Foreign exchange rate gain, net of $92 million in 2024 compared to the foreign exchange rate loss, net of $66 million in 2023 were primarily driven by foreign exchange movements impacting Genmab’s USD denominated assets (excluding marketable securities) and liabilities; in particular, the USD/DKK foreign exchange rates were as follows for each period:

 

		December 31, 2024				December 31, 2023
USD/DKK Foreign Exchange Rates			7.1429				6.7447
% Increase/(Decrease)			6	%			(3	)%

Marketable Securities Gains and Losses

Gain on marketable securities, net was $130 million in 2024 compared to loss on marketable securities, net of $17 million in 2023. The net change is a function of increase in marketable securities balances as well as the position of the portfolio in the changing interest rates environment, primarily in the U.S.

Other Investments

Gains on other investments, net were $6 million in 2024, and losses on other investments, net were $4 million in 2023. The net gains and losses in 2024 and 2023 were primarily driven by changes in fair value of Genmab’s investments in certain strategic investment funds.

Refer to Notes 4.2 and 4.5 of the Genmab Consolidated Financial Statements included in this offering memorandum for further details regarding foreign currency risk and net financial items, respectively.

Corporate Tax

Corporate tax expense was $193 million in 2024 compared to $186 million in 2023. Genmab’s estimated annual effective tax rate was 14.6% in 2024 compared to 22.8% in 2023. The decrease from 2023 to 2024 in Genmab’s effective tax rate was primarily due to the integration of ProfoundBio which allowed for the deduction of previously unrecognized deferred tax assets in 2024.

Refer to Note 2.4 of the Genmab Consolidated Financial Statements included in this offering memorandum for additional information regarding the corporate tax, deferred tax assets and deferred tax liabilities including management’s significant judgments and estimates.

Net Profit

Net profit for 2024 was $1,133 million compared to $631 million in 2023. The changes in net profit for the periods were driven by the items described above.

 

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Liquidity and Capital Resources

Cash Flows

Cash Flows for the Nine Months Ended September 30, 2025 and 2024

The following table provides information regarding Genmab’s cash flow for the nine months ended September 30, 2025 and 2024.

 

		Nine Months Ended September 30,
Cash Flow ($ million)		2025				2024
Net cash provided by operating activities		$	885			$	737
Net cash (used in) investing activities			(71	)			(1,459	)
Net cash (used in) financing activities			(440	)			(564	)
Increase (decrease) in cash and cash equivalents		$	374			$	(1,286	)
Exchange rate adjustments		$	7			$	34

Net cash provided by operating activities is primarily related to our operating profit, changes in operating assets and liabilities, reversal of net financial items, and adjustments related to non-cash transactions. The $148 million increase in net cash provided by operating activities is primarily driven by a $340 million increase in net profit before tax and a $69 million increase related to changes in receivables and other current assets, partly offset by an increase in corporate taxes paid of $268 million.

Net cash used in investing activities primarily reflects differences between the proceeds received from the sale and maturity of our investments and amounts invested, and the cash paid for investments in tangible and intangible assets. The $1,388 million decrease in net cash used in investing activities is primarily driven by the acquisition of ProfoundBio during the second quarter of 2024.

Net cash used in financing activities is primarily related to the purchase of treasury shares, exercise of warrants, lease payments, and payment of withholding taxes on behalf of employees on net settled RSUs. The $124 million decrease in net cash used in financing activities between the periods is primarily driven by $130 million decreased cash paid for the purchase of treasury shares during the first nine months of 2025 compared to the first nine months of 2024 due to the timing of share repurchases. This decrease was partly offset by lower proceeds from the exercise of warrants of $2 million, with $16 million received in the first nine months of 2025 as compared to $18 million in the first nine months of 2024.

Exchange rate adjustments represent foreign currency gains or losses on Genmab’s cash and cash equivalents.

Cash Flows for the Years ended December 31, 2024 and 2023

The following table provides information regarding Genmab’s cash flow for the year ended December 31, 2024 and 2023.

 

Cash Flow ($ million)		2024				2023
Net cash provided by operating activities		$	1,126			$	1,071
Net cash (used in) investing activities			(1,447	)			(185	)
Net cash (used in) financing activities			(566	)			(89	)
Increase in cash and cash equivalents		$	(887	)		$	797
Exchange rate adjustments		$	63			$	(12	)

 

 

129

Net cash provided by operating activities is primarily related to our operating profit, changes in operating assets and liabilities, reversal of net financial items, and adjustments related to non-cash transactions. Net cash provided by operating activities increased in 2024 compared to 2023 primarily driven by an increase in net profit before tax of $509 million, an increase in non-cash transactions of $54 million, and a decrease in taxes paid of $105 million in 2024 compared to 2023, partly offset by significant AbbVie milestones achieved during the fourth quarter of 2022 with related cash received during 2023 and an increase in DARZALEX royalty receivables in the fourth quarter of 2024 compared to the fourth quarter of 2023.

Net cash (used in) investing activities primarily reflects cash used in making acquisitions, differences between the proceeds received from the sale and maturity of our investments and amounts invested, and the cash paid for investments in tangible and intangible assets. The increase from 2023 to 2024 in net cash (used in) investing activities is primarily driven by the acquisition of ProfoundBio.

Net cash (used in) financing activities is primarily related to the purchase of treasury shares, exercise of warrants, lease payments, and payment of withholding taxes on behalf of employees on net settled RSUs. The increase from 2023 to 2024 in net cash (used in) financing activities is primarily driven by cash payments for the purchase of treasury shares of $560 million in 2024 compared to $81 million in 2023.

Exchange rate adjustments represent foreign currency gains or losses on Genmab’s cash and cash equivalents, primarily driven by our cash and cash equivalents holdings denominated in USD. The USD/DKK foreign exchange rate increased 6% in 2024, decreased 3% in 2023.

Cash, Cash Equivalents and Marketable Securities

 

		September 30,
($ million)		2025				2024
Marketable securities		$	1,650			$	1,648
Cash and cash equivalents			1,761				952

As of September 30, 2025, cash and cash equivalents and marketable securities denominated in USD represented 87% of Genmab’s total cash and cash equivalents and marketable securities compared to 80% of September 30, 2024.

Marketable securities are invested in highly secure and liquid investments with short effective maturities. As of September 30, 2025, 70% of Genmab’s marketable securities were long-term A rated or higher, or short-term rated A-1 / P-1 by S&P, Moody’s or Fitch compared to 70% as of September 30, 2024.

As of September 30, 2025, $1,761 million was held as cash and cash equivalents, and $1,650 million was held as liquid investments in short-term government and other debt instruments compared to $952 million held as cash and cash equivalents and $1,648 million held as liquid investments in short-term government and other debt instruments as of September 30, 2024.

Cash and cash equivalents included short-term marketable securities of $140 million at the end of September 2025. In accordance with Genmab’s accounting policy, securities purchased with a maturity of less than 90 days at the date of acquisition are classified as cash and cash equivalents.

Liquidity and Capital Resources Following the Acquisition

Funding of the Acquisition

We expect that the Transactions will require total cash in U.S dollars of approximately $8,395 million, which will be used to fund the Acquisition and to pay fees and expenses associated with the Transactions. We expect the cash requirements of the Transactions to be financed through the net proceeds from the issuance of the notes offered hereby, together with borrowings under the Term Credit Facilities, as well as our cash on hand, including cash from the sale of substantially all of our marketable securities.

 

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See “Use of Proceeds” for more information.

Debt

Currently, we have $0 million in debt as of September 30, 2025. Following consummation of the Transactions, our long-term debt will consist of the notes and indebtedness under the Term Credit Facilities. In connection with this offering, we will also enter into the New Revolving Facility, which we do not expect to draw in connection with the Transactions.

We are seeking consent under the Existing Credit Agreement to permit the consummation of this offering. If this consent is obtained, we expect to terminate the Existing Credit Agreement at the Acquisition Closing Date. If this consent is not obtained, we will terminate the Existing Credit Agreement on the date of the settlement of this offering.

On a pro forma basis giving effect to the Transactions, as of September 30, 2025, we would have had outstanding $5,263 million in aggregate indebtedness for borrowed money, including the Term Credit Facilities and the Notes offered hereby. On a pro forma basis giving effect to the Transactions, assuming the blended interest rate used in the presentation of our pro forma financial statements included elsewhere in this offering memorandum, our cash interest expense would have been $423 million for the twelve months ended December 31, 2024 and $321 million for the nine months ended September 30, 2025.

From time to time, depending upon market and other conditions, as well as upon our cash balances and liquidity, we may acquire our outstanding debt securities or our other indebtedness through open market purchases, privately negotiated transactions, tender offers, redemption or otherwise, upon such terms and at such prices as we may determine, for cash or other consideration.

For additional information regarding our material indebtedness upon the completion of the Transactions, see “Summary—The Transactions,” “Description of Other Indebtedness”, “Description of the Unsecured Notes” and “Description of the Secured Notes”

Liquidity

Prior to consummation of the Transactions, we will require cash to meet our operating expenses and capital expenditures. We have funded our cash requirements since inception, including through September 30, 2025, primarily with royalty and milestone payments from our partners, upfront payments, and equity financing. We expect to continue to fund a significant portion of our development costs for proprietary product candidates as well as commercialization activities prior to consummation of the Transactions with cash received from royalties and milestone payments from partners, and net sales of Genmab products.

After the consummation of the Transactions, our primary sources of liquidity will be cash received from royalties and milestone payments from partners and net sales of our products, our remaining cash, cash equivalents and marketable securities, and our New Revolving Facility, which will permit aggregate borrowings of up to $500 million. Our primary uses of cash after the consummation of the Transactions will be our development costs for our proprietary product candidates, commercialization activities, capital expenditures and debt service obligations.

Based on our current level of operations, our available cash, cash equivalents and marketable securities, we believe our cash flows from operating activities, combined with availability under the New Revolving Facility, will provide sufficient liquidity to fund our development and commercialization activities, current obligations, projected working capital requirements, debt service requirements and capital spending requirements over the next twelve months and the foreseeable future.

 

131

Our expenditures on current and future preclinical and clinical development programs are subject to numerous uncertainties in timing and cost to completion. In order to advance our product candidates toward commercialization, the product candidates are tested in numerous preclinical safety, toxicology and efficacy studies. Genmab then conducts clinical trials for those product candidates that take several years or more to complete. The length of time varies substantially based upon the type, complexity, novelty and intended use of a product candidate. The cost of clinical trials may vary significantly over the life of a project as a result of a variety of factors, including: the number of patients required in the clinical trials; the length of time required to enroll trial participants; the number and location of sites included in the trials; the costs of producing supplies of the product candidates needed for clinical trials and regulatory submissions; the safety and efficacy profile of the product candidate; the use of CROs to assist with the management of the trials; and the costs and timing of, and the ability to secure, regulatory approvals.

Our expenses also fluctuate from period to period based on the degree of activities with collaborative partners, timing of manufacturing campaigns, numbers of patients enrolled in clinical trials and the outcome of each clinical trial event. As a result, we are unable to determine with any degree of certainty the anticipated completion dates, duration and completion costs of research and development projects, or when and to what extent we will receive cash inflows from the commercialization and sale of any product candidates. We also cannot predict the actual amount or timing of future royalties and milestone payments, and these may differ from estimates.

We expect to increase operating expenditures and make additional capital outlays over the next several years as we support preclinical development, manufacturing, clinical trial activities, product collaborations, commercialization activities and additional hiring of staff. The adequacy of our available funds will depend on many factors, including the level of DARZALEX and other royalty streams, progress in our research and development programs, the magnitude of those programs, our commitments to existing and new clinical collaborators, our ability to establish commercial and licensing arrangements, our capital expenditures, market developments, and any future acquisitions. Accordingly, Genmab may require additional funds and may attempt to raise additional funds through equity or debt financings, collaborative agreements with partners, or from other sources. During the fourth quarter of 2024, Genmab entered into the Existing Credit Agreement. The Existing Credit Agreement is an unsecured three-year revolving credit facility of up to $300 million with a syndicate of lenders. Genmab intends to use the Existing Credit Agreement to finance working capital needs, and for general corporate purposes, of Genmab and its subsidiaries. The Existing Credit Agreement includes options to increase the size of the facility up to $500 million as well as the ability to extend for an additional two years. The Existing Credit Agreement contains certain customary financial covenants. As of December 31, 2024, there were no outstanding amounts due on, nor any usage of, the Existing Credit Agreement and Genmab was in compliance with all financial covenants. We expect to terminate the Existing Credit Agreement prior to or concurrently with the closing of the Acquisition

For a discussion on the impact of the Acquisition, please see “—Key Components of Our Results and Related Trends—Impact of the Acquisition of Merus.”

Please also see Note 9 of the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum for a description of our lease obligations; and Note 5.6 of the Genmab Consolidated Financial Statements for a description of our contractual obligations related to a number of agreements, primarily related to research and development activities, as well as a description of our contingent commitments under our license and collaboration agreements that may become due for future payments.

In addition to the above obligations, we enter into a variety of agreements and financial commitments in the normal course of business. The terms generally allow us the option to cancel, reschedule and adjust our requirements based on our business needs prior to the delivery of goods or performance of services.

 

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It is not possible to predict the maximum potential amount of future payments under these agreements due to the conditional nature of our obligations and the unique facts and circumstances involved in each particular agreement.

Significant Accounting Policies

Refer to Note 1.1 of the Genmab Consolidated Financial Statements and Note 1 of the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum for information about our significant accounting policies and how estimates are involved in the preparation of our financial statements.

Implementation of New and Revised Standards and Interpretations

For information related to new and revised standards and interpretations, see Note 1.2 to the Genmab Consolidated Financial Statements and Note 1 to the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum.

Standards and Interpretations Not Yet in Effect

For information related to standards and interpretations not yet in effect, see Note 1.2 to the Genmab Consolidated Financial Statements and Note 1 to the Genmab Unaudited Interim Condensed Consolidated Financial Statements included in this offering memorandum.

Qualitative and Quantitative Disclosures about Market Risks

For information related to qualitative and quantitative disclosures about market risks including foreign currency risk, interest rate risk, and credit risk, see Note 4.2 to the Genmab Consolidated Financial Statements.

 

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DESCRIPTION OF CERTAIN OTHER INDEBTEDNESS

The following is a summary of certain provisions of the expected terms of the New Senior Secured Credit Facilities in which the Issuers intend to enter in connection with the Acquisition Closing. The terms and conditions of the New Senior Secured Credit Facilities described herein have not been finalized, and are therefore subject to change. Investors are encouraged not to place undue reliance on such descriptions in deciding to invest in the Notes offered hereby, as changes may be made after the date of this offering memorandum.

In connection with the Acquisition, the Issuers expect to enter into a credit agreement governing the New Senior Secured Credit Facilities with Morgan Stanley Senior Funding Inc., as administrative agent and collateral agent and various financial institutions as lenders thereunder. Merus and its wholly owned subsidiaries are expected to become guarantors under the New Senior Secured Credit Facilities and provide applicable collateral which will be required under the New Senior Secured Credit Facilities after the Back-End Closing.

Maturity and Amortization

The Term Loan A Facility will mature on the fifth anniversary of the Acquisition Closing and amortize in equal quarterly installments in aggregate annual amounts equal to 5.0% of the original principal amount of the Term Loan A Facility, with the balance of the original principal amount of the Term Loan A Facility payable at maturity. The Term Loan B Facility will mature on the seventh anniversary of the Acquisition Closing and amortize in equal quarterly installments in aggregate annual amounts equal to 10% in 2026, 15% in 2027 and 2028, 10% in 2029, and 5% in 2030, 2031, and 2032, in each case, of the original principal amount of the Term Loan B Facility, with the balance of the original principal amount of the Term Loan B Facility payable at maturity. The Revolving Facility will mature, and the commitments thereunder will terminate, on the fifth anniversary of the Acquisition Closing.

Interest

The interest rate on each of the Term Loan A Facility and the Revolving Facility is expected to be based on, at the option of the Issuers, either Term SOFR (as will be defined in New Senior Secured Credit Facilities and subject to a 0% floor) or alternate base rate (subject to a 1% floor), in each case, plus an applicable margin that will initially be fixed and, after the delivery of financial statements for the first full fiscal quarter completed after the Acquisition Closing, will vary based on our first lien secured net leverage ratio. The interest rate on the Term Loan B Facility is expected to be based on, at the option of the Issuers, either Term SOFR (subject to a 0% floor) or alternate base rate (subject to a 1% floor), in each case, plus an applicable margin.

Mandatory Prepayments

Subject to certain important exceptions and thresholds, it is expected that the Issuers will be required to make mandatory prepayments under certain circumstances, with excess cash flow, the net proceeds of asset sales and casualty events (subject to customary reinvestment rights) and the incurrence of indebtedness that is not permitted under the New Senior Secured Credit Facilities.

Voluntary Prepayments

The Issuers may voluntarily repay outstanding loans under the Term Loan A Facility and Term Loan B Facility at any time without prepayment premium or penalty, except in connection with a repricing event in respect of the term loans under the Term Loan B Facility as described below, subject to customary “breakage” costs with respect to loans bearing interest at Term SOFR.

 

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It is expected that any refinancing through the issuance of certain debt or any repricing amendment, in either case, that constitutes a “repricing event” applicable to the term loans under the Term Loan B Facility resulting in a lower yield occurring at any time during the first six months after the closing date of the Term Loan B Facility will be accompanied by a 1.00% prepayment premium or fee, as applicable.

Guarantees and Security

The obligations of the Issuers under the New Senior Secured Credit Facilities will be guaranteed, on a joint and several basis, by the Guarantors. The obligations of the Issuers under the New Senior Secured Credit Facilities will be secured, on a joint and several basis, by first-priority liens (subject to permitted liens) on certain of the Issuers’ and the Guarantors’ existing and future assets (subject to certain exclusions and agreed guarantee and security principles in line with customary practices in the relevant jurisdiction), which will rank pari passu with the liens securing the Secured Notes offered hereby pursuant to a customary intercreditor agreement governing relative priority and creditor rights. See “Description of the Secured Notes—Equal Priority Intercreditor Agreement.” On the Acquisition Closing, security jurisdictions will be limited to the U.S., Denmark and the Netherlands.

Representations, Warranties and Covenants

The New Senior Secured Credit Facilities will contain representations and warranties and affirmative covenants that are usual and customary for facilities of this nature and subject to important limitations and exceptions. The New Senior Secured Credit Facilities will also contain customary negative covenants (subject to important limitations and exceptions) that include limitations on indebtedness, liens, asset sales, investments, restricted payments, restricted debt prepayments, affiliate transactions, fundamental changes, material changes in nature of business, negative pledge clauses, and changes to fiscal year. Solely with respect to the Term Loan A Facility and the Revolving Facility, the Issuers will be subject to quarterly-tested maintenance financial covenants that require compliance with a maximum First Lien Secured Net Leverage Ratio (as will be defined in the New Senior Secured Credit Facilities) and a minimum Interest Coverage Ratio (as will be defined in the New Senior Secured Credit Facilities).

Events of Default

The New Senior Secured Credit Facilities will contain customary events of default (subject to important limitations and exceptions), including with respect to non-payment of principal, non-payment of interest and fees subject to a grace period, covenant breaches subject to a grace period for certain covenants, material misrepresentations subject to a grace period for certain representations, cross-defaults to material indebtedness above a materiality threshold, monetary judgments above a materiality threshold, insolvency or bankruptcy events, change of control, certain ERISA (as defined herein) events, and invalidity of a material portion of guarantees or security. If an event of default occurs, the lenders under the New Senior Secured Credit Facilities will be entitled to take various actions, including the acceleration of amounts due under the New Senior Secured Credit Facilities and all actions permitted to be taken by secured creditors.

 

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Exhibit 99.4

EXHIBIT B

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

Introduction

On September 29, 2025, Genmab entered into the Acquisition, to which Genmab intends to acquire all the shares of Merus for $97.00 per share in an all-cash transaction. The following unaudited pro forma condensed combined financial information gives effect to the Acquisition and the related financing transactions, as further described below.

The accompanying unaudited pro forma condensed combined statement of financial position as of September 30, 2025 gives effect to the Acquisition, including the related financing transactions, as if it had been consummated on September 30, 2025; and the accompanying unaudited pro forma condensed combined statements of operations for the year ended December 31, 2024 and the nine months ended September 30, 2025 give effect to the Acquisition, including the related financing transactions, as if it had been consummated on January 1, 2024.

These unaudited pro forma condensed combined financial statements should be read in conjunction with:

 

•

The accompanying notes to these unaudited pro forma condensed combined financial statements,

 

•

The historical audited consolidated financial statements of Genmab for the year ended December 31, 2024, as reissued,

 

•

The historical unaudited interim condensed consolidated financial statements of Genmab for the nine months ended September 30, 2025,

 

•

The historical audited consolidated financial statements of Merus for the year ended December 31, 2024,

 

•

The historical unaudited interim condensed consolidated financial statements of Merus for the nine months ended September 30, 2025,

 

•

The section of this offering memorandum entitled “Management’s Discussion and Analysis of Financial Condition and Results of Operations.”

See the section of this offering memorandum entitled “Notes to Unaudited Pro Forma Consolidated Combined Financial Information.”

The historical audited consolidated financial statements and historical unaudited interim condensed consolidated financial statements of Genmab have been prepared in accordance with IFRS Accounting Standards, and IAS 34 Financial Information, respectively. The historical audited consolidated financial statements and historical unaudited interim condensed consolidated financial statements of Merus have been prepared in accordance with U.S. GAAP and with Regulation S-X promulgated under the Securities Exchange Act of 1933, as amended.

The unaudited pro forma adjustments are based upon available information and certain assumptions that management believes are reasonable. All adjustments are preliminary and subject to change.

These unaudited pro forma condensed combined financial statements are for illustrative purposes only and are not intended to represent or be indicative of:

 

•

The actual results of operations or financial position of the combined company that would have been achieved if the Acquisition had been completed as of the dates indicated, or

 

•

The results of operations or financial position of the combined company as of any future date or for any future period.

 

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Description of the Transaction

On September 29, 2025, Merus entered into the Transaction Agreement with Genmab and the Purchaser. Pursuant to the Transaction Agreement, the Purchaser commenced a tender offer for all the outstanding common shares of Merus on October 21, 2025. The closing of the tender offer is subject to the satisfaction or waiver of customary conditions as described elsewhere in this offering memorandum. Following the closing of the tender offer, Merus and Genmab will effect the Back-End Transactions resulting in Genmab owning 100% of the common shares of Merus (or a successor entity). Depending on the structure of these Back-End Transactions, Merus shareholders that do not tender their shares into the tender offer will either receive the same consideration for their common shares as the common shares tendered into the tender offer (subject to applicable withholding taxes) or a fair price for their common shares determined by a Dutch court in statutory buy-out proceedings. For purposes of this unaudited pro forma condensed combined financial information, we have assumed that the purchase of Genmab’s majority interest in Merus through the tender offer and the acquisition of any remaining Merus shares through the Back-End Transactions will occur during the same reporting period and at the same per share purchase price.

Merus Equity awards

In connection with the transaction Merus equity awards will be treated as follows:

Merus Stock Options: each outstanding and unexercised option that is outstanding immediately prior to the closing of the transaction, whether or not fully vested, and whether or not subject to any performance or other conditions, will vest in full. “In-the-money” options will be converted automatically into the right to receive cash equal to the merger consideration less the strike price for each in the money award.

Merus Restricted Stock Award: each outstanding and unvested restricted stock award outstanding immediately prior to the closing of the transaction, whether or not fully vested, and whether or not subject to any performance or other conditions, will vest in full and be converted automatically into the right to receive cash equal to the merger consideration available to holders of common shares.

Description of the Financing

To finance the Transactions, Genmab has obtained committed financing from several financial institutions in the aggregate amount of $6,000 million, of which $5,500 million is intended to be used to finance, in part, the aggregate consideration for the Acquisition and $500 million is committed pursuant to a revolving credit facility that is expected to be undrawn at the closing of the Acquisition. In connection with the Transactions, the Company intends to enter into the following debt financing transactions:

 

•

the entry into New Senior Secured Credit Facilities consisting of (i) the Term Loan A Facility, (ii) the Term Loan B Facility, and (iii) the New Revolving Facility; and

 

•

the issuance of (i) $1,500 million in aggregate principal amount of the senior secured notes offered hereby and (ii) $1,000 million in aggregate principal amount of the senior unsecured notes offered hereby.

Accounting for the Acquisition

The transaction will be accounted for in accordance with IFRS Accounting Standards. It is anticipated to be treated as the acquisition of a group of assets that do not constitute a business, as outlined in the scoping guidance in IFRS 3.2 and the related IFRS Interpretations Committee Update in November 2017 (“IU 11-17”). This is because it is anticipated that substantially all the fair value of the gross assets acquired will be concentrated into a single asset. Following the guidance provided by the IU 11-17 meeting and set forth in IFRS 3.2(b), Genmab will measure any identifiable assets or assumed liabilities that are initially measured at an amount other than cost in accordance with the applicable accounting standards, and allocate the residual cost of the asset acquisition to the remaining identifiable assets based on their preliminary estimates of fair value.

 

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The transaction will not result in the recognition of any goodwill, gain or loss. Further, the transaction will not result in the recognition of any deferred tax asset or liability as IFRS Accounting Standards do not permit the recognition of deferred taxes that arise from initial recognition of an asset or liability in a transaction that is an asset acquisition, does not give rise to an accounting or tax profit, and does not give rise to equal taxable and deductible temporary differences. Directly attributable transaction costs necessary to execute the transaction are capitalizable and form part of the cost basis of the net assets acquired. The detailed valuation studies necessary to arrive at required estimates of fair values of the assets acquired and liabilities assumed from Merus in the transaction have not been completed. The actual fair values will be determined upon the completion of the Transaction and the dependent allocations may vary materially from these preliminary estimates.

While following the initial tender offer, but prior to the completion of the Back-End Transactions, Genmab may own less than 100% of the outstanding shares of Merus, the transaction is presented here as if Genmab has achieved 100% ownership upon closing of the tender offer because the remaining shares will eventually be acquired by Genmab during the subsequent offering period or through the successful completion of the Back-End Transactions. All Back-End Transactions are expected to be completed in the same reporting period, and the unaudited pro forma condensed combined financial information presented herein has been prepared on this basis. If the Back-End Transactions are not completed within the same reporting period, there may be recognition of a mandatorily redeemable financial instrument. The accounting for this transaction is preliminary and has not yet been finalized.

Pro forma Adjustments

The following unaudited pro forma condensed combined statement of operations for the nine months ended September 30, 2025 and the year ended December 31, 2024 and unaudited pro forma condensed combined statement of financial position as of September 30, 2025 are based on the historical consolidated financial statements of Genmab and Merus, and have been prepared to reflect the Acquisition and the financing arrangements contemplated at the date of this offering memorandum. The pro forma adjustments related to the transaction include:

 

•

The purchase consideration of $97.00 per share transferred to holders of shares, options, and restricted stock awards outstanding as of September 26, 2025, resulting in an estimated consideration paid to such holders of $8,014 million.

 

•

The conversion of Merus financial statements from U.S. GAAP and Merus accounting policies to Genmab accounting policies in accordance with IFRS Accounting Standards and reclassifications to conform to Genmab financial statement presentation.

 

•

The recognition of Merus’ net assets acquired and liabilities assumed in the Acquisition, measured at their allocated transaction price, as described above.

 

•

The borrowings under the term loan facilities and the issuance of the secured and unsecured notes offered hereby, each further described in Note 4—Adjustments for Financing of the unaudited pro forma condensed combined financial information, and the planned liquidation of marketable securities to fund a portion of the purchase price of the Acquisition.

 

•

The recognition of certain one time transaction related expenses and the recognition of incremental share based compensation expense attributable to the acceleration of share based payment awards in conjunction with the transaction, as if the transaction had occurred on January 1, 2024, each described in Note 5—Other Transaction Accounting Adjustments of the unaudited pro forma condensed combined financial information.

The unaudited pro forma condensed combined financial statements have been prepared in accordance with Article 11 of Regulation S-X as amended by the final rule, Release No. 33-10786 “Amendments to Financial Disclosures about Acquired and Disposed Businesses.” Release No.

 

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33-10786 established simplified requirements to depict the accounting for the transaction (“Transaction Accounting Adjustments”). These pro forma adjustments were presented in separate columns after the presentation of the combined historical information of the Company and its subsidiaries and Merus and its subsidiaries. The Company has elected not to present management’s adjustments and is only presenting Transaction Accounting Adjustments in the unaudited pro forma condensed combined financial information. The pro forma adjustments are subject to material change and are based upon currently available information and certain assumptions that the Company believes are reasonable.

This information has been prepared assuming (1) that Genmab irrevocably accepts for payment all Merus shares, tendered during the initial tender offer period, on a fully diluted basis and (2) that the Back-End Transactions, including the back-end merger, the back-end loan and the back-end cancellation, to the extent applicable, occur within the same reporting period; resulting in Genmab acquiring 100% of outstanding shares of Merus. The unaudited pro forma condensed combined financial information does not reflect any anticipated synergies or dis-synergies, operating efficiencies or cost savings, or integration costs that may result from the Acquisition. No assurance can be given that synergies, operating efficiencies or cost savings will be realized. Income taxes do not reflect the amounts that would have resulted had Genmab and Merus filed consolidated income tax returns during the periods presented.

 

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Unaudited Pro Forma Condensed Combined Statement of Financial Position

As at September 30, 2025

 

										Transaction Accounting Adjustments
($ in millions, except per share data)		Genmab Historical (IFRS)				Merus (IFRS)				Acquisition								Financing								Others								Pro Forma Combined
						Note 2				Note 3								Note 4								Note 5
Assets
Goodwill		$	355			$	—			$	—							$	—							$	—							$	355
Other intangible assets			1,748				2				7,316				(ii)				—								—								9,066
Property and equipment			145				11				—				(iii)				—								—								156
Right-of-use assets			121				12				—				(v)				—								—								133
Receivables			9				—				—								—								—								9
Deferred tax assets			127				1				(1	)			(vi)				—								—								127
Prepaid expenses and other non-current assets			9				2				—								—								—								11
Other investments			36				183				—				(iv)				—								—								219
Total non-current assets		$	2,550			$	211			$	7,315							$	—							$	—							$	10,076
Corporate tax receivable			—				—				—								—								—								—
Inventories			14				—				—								—								—								14
Receivables			1,046				19				—								—								—								1,065
Prepaid expenses and other current assets			—				37				—								—								—								37
Marketable securities			1,650				268				—								—								(1,650	)			(ii)				268
Cash and cash equivalents			1,761				369				(8,158	)			(i)				5,263				(i)				1,650				(ii)				885
Total current assets		$	4,471			$	693			$	(8,158	)						$	5,263							$	—							$	2,269
Total assets		$	7,021			$	904			$	(843	)						$	5,263								—							$	12,345
Shareholders’ Equity and Liabilities
Share capital			10				8				(8	)			(vii)				—								—								10
Share premium			1,913				2,066				(2,066	)			(vii)				—								—								1,913
Other reserves			(204	)			19				(19	)			(vii)				—								—								(204	)
Retained earnings			4,032				(1,318	)			1,250				(vii)				—								—								3,964
Total shareholders’ equity		$	5,751			$	775			$	(843	)							—								—							$	5,683
Lease liabilities			126				9				—								—																135
Contract liabilities			67				33				—								—																100
Borrowings—non-current			—				—				—								5,013				(i)				—								5,013
Deferred tax liabilities			330				—				—								—								—								330
Other payables			6				—				—								—								—								6
Total non-current liabilities		$	529			$	42			$	—							$	5,013							$	—							$	5,584
Corporate tax payable			120				7				—								—								—								127
Lease liabilities			16				3				—								—								—								19
Borrowings—current			—				—				—								250				(i)				—								250
Contract liabilities			3				24				—								—								—								27
Other payables			602				53				—								—								—								655
Total current liabilities		$	741			$	87			$	—							$	250								—							$	1,078
Total liabilities		$	1,270			$	129				—								5,263								—							$	6,662
Total shareholders’ equity and liabilities		$	7,021			$	904			$	(843	)						$	5,263								—							$	12,345

 

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