A Diversified Oncology Drug Development Company June 2023 ASX: KZA | NASDAQ: KZIA | Twitter: @KaziaTx

Forward-Looking Statements This presentation contains forward-looking statements, which can generally be identified as such by the use of words such as “may,” “will,” “estimate,” “future,” “forward,” “anticipate,” “plan,” “expect,” “explore,” “potential” or other similar words. Any statement describing Kazia's future plans, strategies, intentions, expectations, objectives, goals or prospects, and other statements that are not historical facts, are also forward-looking statements, including, but not limited to, statements regarding: the timing for interim or final results and data related to Kazia’s clinical and preclinical trials, or third-party trials evaluating Kazia’s product candidates, timing and plans with respect to enrolment of patients in Kazia’s clinical and preclinical programs and Kazia’s strategy and plans with respect to its programs, including Paxalisib and EVT-801. Such statements are based on Kazia’s expectations and projections about future events and future trends affecting its business and are subject to certain risks and uncertainties that could cause actual results to differ materially from those anticipated in the forward-looking statements, including risks and uncertainties: associated with clinical and preclinical trials and product development, related to regulatory approvals, risks related to Kazia’s executive leadership changes, and the related to the impact of global economic conditions, including disruptions in the banking industry. These and other risks and uncertainties are described more fully in Kazia’s Annual Report, filed on form 20-F with the SEC, and in subsequent filings with the SEC. Kazia undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise, except as required under applicable law. You should not place undue reliance on these forward-looking statements, which apply only as of the date of this presentation. 1

Company Overview A late-clinical-stage oncology drug development company Paxalisib EVT801 Company is dual-listed on NASDAQ (KZIA) and ASX (KZA) with market cap around US$ 27 million Brain-penetrant pan-PI3K / mTOR inhibitor Selective VEGFR3 inhibitor • Well-validated class with five FDA-approved therapies• Designed to avoid off-target toxicity of older • Only brain-penetrant PI3K inhibitor in development angiokinase inhibitors • Primarily targets lymphangiogenesis Licensing-driven business model, with programs sourced from Genentech (paxalisib) and Sanofi / Evotec In development for multiple brain cancers Currently in phase I for advanced solid tumors (EVT801) • Clinical trials ongoing in brain metastases, childhood • Adaptive, biomarker study ongoing at 2 leading cancer brain cancer, glioblastoma, IDH-mutant glioma, and sites in France primary CNS lymphoma Unique asset being evaluated in multiple trials Cash runway into 4Q23, with potential Potential use in many solid tumors opportunities for non-dilutive income via • Multiple signals of clinical activity across several • Potential indications include: ovarian cancer, renal cell additional partnering activity cancer types carcinoma, liver cancer, colon cancer, and sarcoma • Fast Track, Orphan Drug, and Rare Pediatric Disease Designations from US FDA Rich potential commercial opportunity Potential combination with immunotherapy Lean virtual pharma model, with ~75% • Glioblastoma alone sized at US$ 1.5 billion per annum• Strong evidence of synergy in preclinical data supports of cashflows applied directly to clinical • Commercial licensee in place for China potential of monotherapy or combination use trials Final Phase III Data: Anticipated 2H CY2023 Initial Phase I Data: Anticipated 2HCY2023 2

Pipeline – Two Differentiated Assets Lead asset provides a ‘pipeline in a molecule’ licensed from: Paxalisib Investigational, small molecule, potent, brain-penetrant inhibitor of PI3K / mTOR Preclinical PHASE 1 PHASE 2 PHASE 3 MARKET Anticipated Final Data Glioblastoma & IDH-mutant glioma 3 studies 2H CY23 Common primary brain cancer Initial Data DIPG/Advanced Solid Tumors 3 studies 3Q CY23 Childhood brain cancer Further Data AT/RT 1H CY23 Childhood brain cancer Further Data Brain Metastases 3 studies CY23 Cancer that spreads to brain from elsewhere Initial Data Primary CNS Lymphoma 1 study CY23 Form of non-Hodgkin’s lymphoma Further Data Cancers outside the CNS CY23 Melanoma; TNBC, Ovarian licensed from: EVT801 Investigational, small molecule, highly specific inhibitor of VEGFR3 Initial Data Advanced Solid Tumors 2H CY23 Patients w/ highly treatment-resistant cancer IDH: Isocitrate dehydrogenase, DIPG: Diffuse Intrinsic Pontine Glioma, AT/RT: Atypical Teratoid Rhabdoid Tumor, CNS: central nervous system, TNBC: triple negative breast cancer, VEGFR3: vascular endothelial growth factor receptor 3 3

Paxalisib History Asset licensed from Genentech in 2016 Kazia commences phase I clinical Kazia commences phase II Positive final data from phase II trial in diffuse midline glioma clinical trials in brain metastases glioblastoma study • Partnership with St Jude • Partnerships with leading US • Basis for launch of pivotal GBM Children’s Research Hospital specialist cancer centres AGILE trial in Jan 2021 2016 2017 2018 2019 2020 2021 2022 Kazia licenses paxalisib from Kazia commences phase II Greater China rights licensed to Multiple positive data read -outs Genentech, Inc clinical trial in glioblastoma Simcere Pharmaceutical in various cancers • $5 million upfront payment • 6 leading US based cancer • $11 million upfront payment • 2 brain mets studies graduate • Royalties on commercial sales centres • Up to $281 million in milestone to expansion stages • Asset licensed after strategic • Focuses development on payments • Compelling preclinical DIPG review by Genentech refocused newly-diagnosed patients, a • Mid- to high -teen royalties on data in combination with R&D on immuno-oncology and larger commercial opportunity net sales in greater China ONC201 presented tumors outside the brain and more treatment - • Positive preclinical data in responsive population AR/RT • Positive preclinical data in melanoma Collaborations with Leading Brain Cancer Research Centres 4

CY2023 Milestones and Newsflow Multiple catalysts across two clinical programs Preclinical data for paxalisib in melanoma presented at AACR (2023) 1H CY2023 ü Preclinical data for paxalisib in DMG/DIPG & AT/RT presented at AACR (2023) 1H CY2023 ü Preliminary data from Kazia’s EVT801 phase I trial presented AACR 2023 1H CY2023 ü Initiate OPTIMISE clinical study in pediatric PI3K/mTOR activated cancers 1H CY2023 ü Initiate LUMOS2 clinical study in adult IDH -mutant glioma patients w/PI3K/ mTOR mutations 1H CY2023 ü Initial interim data from paxalisib phase II DIPG study with PNOC 3Q CY2023 EVT801 Stage 1 completion 2H CY2023 QIMR preclinical data and provisional patent update 2H CY2023 Initial interim data from paxalisib phase II PCNSL study at Dana -Farber 2H CY2023 Further interim data from paxalisib brain metastases trials 2H CY2023 Final data from GBM AGILE pivotal study of paxalisib 2H CY2023 Paxalisib + radiotherapy Stage 2 data phase I brain mets study at Memorial Sloan-Kettering 1Q CY2024 Note: all guidance is indicative, and subject to amendment in light of changing conference schedules, operational considerati ons, etc Kazia is not the sponsor of all planned/ongoing studies and may have limited control or visibility into study timelines . 5

Paxalisib Mechanism of Action Only brain-penetrant drug in development within the PI3K inhibitor class 1 2 3 The PI3K pathway is activated in Five PI3K inhibitors have already Paxalisib is the only brain- been approved by FDA penetrant PI3K inhibitor many forms of cancer • Chronic lymphocytic Only 2% of small-molecule Glioblastoma 90% leukemia drugs are brain-penetrant • Follicular lymphoma • Follicular lymphoma Breast 80% Lung 75% • Chronic lymphocytic leukemia • Follicular lymphoma Endometrial 60% • Breast cancer Ovarian 60% Not able to cross blood-brain barrier • Follicular lymphoma Able to cross blood-brain barrier Prostate 45% Source: Data on file 6

Glioblastoma 7

Paxalisib in Glioblastoma High unmet need, especially in ‘MGMT unmethylated’ patients Standard of Care Debulking surgery Radiotherapy + Temozolomide (‘Stupp where possible temozolomide maintenance therapy Regimen’) 6 weeks 4w 6 x 28-day cycles Methylated MGMT Status ~35% of patients respond to temozolomide Extends overall survival from Paxalisib is being developed primarily for 15 to 22 months the ~65% of newly-diagnosed GBM patients who will not respond to existing chemotherapy with temozolomide Unmethylated MGMT Status For these patients, there is no effective ~65% of patients don’t respond pharmacological treatment currently available to temozolomide Extends overall survival from 12 to 13 months Source: ME Hegi, A-C Diserens, T Gorlia, et al. (2005). N Engl J Med 352:997-1003 Note: Temozolomide is only approved therapy for newly-diagnosed patients; Avastin (bevacizumab) is approved for use in recurrent setting MGMT: O6-methylguanine-DNA methyltransferase 8

Paxalisib in Glioblastoma Phase II study suggests encouraging PFS and OS in context of current treatment landscape Progression-Free Survival (PFS) Overall Survival (OS) (n=30) (n=30) Median PFS: 8.6 months (6.6-11.0) Median OS: 15.7 months (11.1-19.1) Comparator figure for existing therapy: 5.3 months Comparator figure for existing therapy: 12.7 months (Hegi et al. 2005) (Hegi et al. 2005) Note: figures for existing therapy are for temozolomide, per Hegi et al. (2005); No head-to-head studies have been published 9

Paxalisib in Glioblastoma Safety profile in Phase II study is favorable for a drug in advanced cancer Number of Patients at Any Dose (n=30) Experiencing AEs ‘Possibly’ or ‘Likely’ Related to Paxalisib (affecting ≥10% of patients) Term Gr 1 Gr 2 Gr 3 Gr 4 Total (%) Fatigue 3 13 2 18 (60%) Stomatitis 4 7 3 14 (47%) Decreased appetite 6 6 1 13 (43%) Hyperglycemia 3 1 6 2 12 (40%) Nausea 4 6 1 11 (37%) Rash, maculo-popular 1 1 7 9 (30%) Diarrhea 7 1 8 (27%) Vomiting 4 2 1 7 (23%) Rash 2 4 1 7 (23%) Neutrophils decreased 3 3 1 7 (23%) Platelets decreased 6 1 7 (23%) Weight decreased 5 2 7 (23%) Lymphocytes decreased 2 3 5 (17%) Dehydration 4 1 5 (17%) Dysgeusia 4 4 (13%) Cholesterol increased 4 4 (13%) ALT increased 1 2 3 (10%) Triglycerides increased 1 2 3 (10%) Malaise 2 1 3 (10%) 10

Paxalisib in Glioblastoma Adaptive multi-drug study, GBM AGILE, is ongoing Key Points Completed Regorafenib Negative outcome Bayer (Sep 22) • A ‘platform study’, sponsored by GCAR run independently of individual 3 Ongoing Paxalisib companies, designed to expedite the No graduation to Stage Kazia Therapeutics 2 (Aug 22) Economies of approval of new drugs for scale due to 2 multiple Ongoing glioblastoma VAL-083 Comparison participating No public information Kintara Therapeutics on graduation against a drugs allows for • Multiple drugs are evaluated in common control large site pool, parallel, saving time and money arm reduces robust study Ongoing Troriluzole overall subject infrastructure, Joined study in Jan 22 Biohaven Pharmaceuticals • Not a ‘winner -takes-all’ approach: numbers, saving and reduced cost time and cost multiple drugs can succeed (no arm vs. arm Ongoing VT1021 comparison) Joined study in Jan 22 Vigeo Therapeutics • Cutting -edge ‘adaptive design’ avoids redundant recruitment, expediting path to market Shared Control Arm • FDA acknowledged that GBM-AGILE data may be suitable for registration Adaptive study design limits Primary endpoint is overall 1 4 number of subjects to that survival (OS), the ‘gold required to demonstrate efficacy, standard’ for approval of eliminating redundancy new cancer drugs GCAR: Global Coalition for Adaptive Research 11 Randomization

Paxalisib in Glioblastoma We believe GBM AGILE’s interim analysis may have been premature OVERALL STUDY DESIGN up to 150 patients 50 patients Stage 1 (‘Exploratory’) Stage 2 (‘Confirmatory’) Full FDA Approval Blinded Graduation Analysis POTENTIAL CONTRIBUTORY FACTORS TO PAXALISIB GRADUATION RESULT Graduation threshold is high Back-loaded recruitment may have Treatment effect typically becomes 1 2 3 reduced statistical power at graduation clearer as study matures 100% efficacy ILLUSTRATIVE Recruitment ILLUSTRATIVE % Survival ILLUSTRATIVE Potential Graduation to range of Stage 2 Treatment statistically Number of significant patients signal that Control may support Paxalisib is FDA approval Time Time likely in this B A range Time in study A At an early point in the study, there is limited Termination separation of curves for futility Statistical Number of Time in = x B As the study matures over time, treatment effect Power Patients study 0% efficacy becomes more apparent ® Avastin (bevacizumab) was approved for GBM AGILE has recruited ~3-4 times faster Final analysis will be performed 12 months recurrent glioblastoma by FDA in 2009 with no than originally anticipated; many paxalisib after last patient enrolled; graduation analysis evidence of any survival benefit patients likely have limited time in study may include <60% of final study information 12

Paxalisib in Glioblastoma Cornell study to investigate if low-insulin state enhances paxalisib activity OVERALL STUDY DESIGN Rationale of conducting the study • As with most PI3K inhibitors, Newly-diagnosed GBM hyperglycemia is a key toxicity (unmethylated MGMT) Ongoing Paxalisib + metformin Study anticipated to take ~2 + ketogenic diet • Insulin regulated glucose years to complete (2024) metabolism partly via PI3K-Akt- Recurrent GBM driven signalling • Insulin signalling and PI3K 30 patients Up to 16 patients in each arm inhibition are essentially Stage 2 (‘Confirmatory’) antagonistic Stage 1 (‘Exploratory’) • The interaction between PI3K inhibition and insulin signalling Primary Endpoint: progression-free survival at six months (PFS6) 1 may drive hyperglycemia and 2 Secondary Endpoints: Overall survival, insulin levels and metabolic markers differential efficacy Source: NCT05183204 13

Paxalisib in Grade 2/3 IDH-Mutant Glioma LUMOS 2 Clinical Study • LUMOS2 is a prospective, multi-center, open-label, multi-arm, phase II, biomarker-directed, signal-seeking, umbrella clinical trial sponsored by University of Sydney – Adults with progressive grade 2/3, IDH-mutant glioma at recurrence after prior treatment with radiotherapy and alkylating chemotherapy who are eligible and willing to undergo tumour resection and will undergo genetic/molecular profiling – The genetic testing results will serve as a recommendation to be assigned to a treatment arm. Patients with PI3K-related mutations will be randomized to receive paxalisib – Primary objective of the study is to determine progression-free survival at six months (PFS6) with overall survival, response rate and health-related quality of life as secondary endpoints. • Anticipate the first patient to be enrolled 4Q23 14

Childhood brain cancers 15

Summary of Paxalisib in Childhood Brain Cancer Kazia has interest in at least three forms of childhood brain cancer Advanced Childhood Cancer Diffuse Midline Gliomas (DMG, Atypical Teratoid / (PI3K/mTOR activated) DIPG) Rhabdoid Tumors (AT/RT) Positive preclinical data as Positive preclinical data in combination Preclinical Research proposals under discussion monotherapy and in combination with ONC201 Research (AACR 2022, 2023) Phase I monotherapy clinical trial Additional clinical trial opportunities Clinical trial opportunities under nearing completion at St Jude under discussion for medulloblastoma Clinical Trials discussion Children’s Research Hospital and HGG Phase II clinical trial in combination Phase II clinical trial in combination with chemotherapy for treatment of with ONC201, commenced recruitment high-risk malignancies including (but in Nov 2021 not confined to) brain tumors Orphan Drug Designation (ODD) and Regulatory Orphan Drug Designation (ODD) Rare Pediatric Disease Designation Regulatory strategy under discussion Interaction granted by FDA in June 2022 (RPDD) granted by FDA in Aug 2020 16

Paxalisib in Childhood Brain Cancer High unmet need especially in patients with diffuse midline gliomas (DMGs) Brain cancer is the most common Brain cancer represents about one third Prognosis of childhood brain cancer, 1 2 3 malignancy of childhood of childhood cancer deaths especially DMGs, has improved little in recent decades Source: CBTRUS; CDC; Ages 0-14 shown; Adamson PC, CA Cancer J Clin. 2015;65:212–220 17

Paxalisib in Diffuse Midline Gliomas Phase I trial (St. Jude Children study) showed paxalisib was generally well tolerated in children OVERALL STUDY DESIGN Results from Phase I trial ✓ MTD of paxalisib has been established Newly diagnosed H3K27-mutant Newly-diagnosed DIPG DMG ✓ Paxalisib exhibited a generally favorable tolerability profile in children, with toxicity profile (rash, hyperglycemia and neutropenia were the most common Standard radiation therapy reported serious adverse events) being comparable to that observed in adults and consistent with other agents in the Varying doses of paxalisib same class 2 2 2 2 21 mg/m , 27 mg/m , 35 mg/m , or 45 mg/m ✓ Data published SNO Scientific Meeting 2020 18

Paxalisib in Diffuse Midline Gliomas Combination of ONC201 and paxalisib appeared synergistic in preclinical model The in vivo xenograft model demonstrated extended Addition of paxalisib rescued ONC201 from pAKT survival with the addition of paxalisib activation Jackson, et al. ONC201 in combination with paxalisib is a therapeutic strategy for diffuse midline glioma. Cancer Research, 2023/5/17 19

Paxalisib in Diffuse Midline Gliomas Multi-arm, global site study, PNOC022, is underway OVERALL STUDY DESIGN Single agent in target validation Combination therapy in Three different cohorts and/or radiation phase maintenance phase TV: ONC201 Day -1 ONC201 once weekly + paxalisib Newly-diagnosed DMG RP: ONC201 once weekly once daily • ~324 patients ONC201 once weekly + paxalisib TV: ONC201 Day -2 and -1 • ~30 global sites Post-radiation therapy once daily RP: ONC201 once weekly ONC201 once weekly + paxalisib TV: Paxalisib Day -1 Recurrent / Progressive RP: Paxalisib once daily once daily REGULATORY STRATEGY ✓ Orphan Drug Designation in DIPG / DMGs ✓ Rare Pediatric Disease Designation in DIPG / DMGs • Evaluate possibility of NDA filing in DIPG / DMGs on the basis of data from PNOC022 study (2H CY2023) • Successful NDA approval may provide a pediatric Priority Review Voucher (pPRV) – current value ~US$ 110M 20 Randomization

Paxalisib in Diffuse Midline Gliomas Case studies from compassionate use suggest activity Patient 1 Patient 2 • Commenced ONC201 + paxalisib immediately • Commenced ONC201 + paxalisib following following re-irradiation radiotherapy after diagnosis • At 5 months, MRI showed continued regression of • Tumor size has decreased by 80% (versus diagnosis) primary tumor and clinical improvement or 68% (versus post-RT) • Patient succumbed unexpectedly of pneumonia, with • Patient has returned to school with marked reduction autopsy showing no evidence of new tumor growth or of DIPG-associated symptoms, and continued tumor tumor-related mortality regression Jackson, et al. ONC201 in combination with paxalisib is a therapeutic strategy for diffuse midline glioma. Cancer Research, 2023/5/17 21

Paxalisib in Childhood Brain Cancer Australian phase II study, OPTIMISE, anticipated enrollment in 2H 2023 The trial explores paxalisib in combination with existing chemotherapy agents for the treatment of children with high-risk malignancies, including (but not confined to) brain tumors 100 patients 18 patients Stage 1 (‘Exploratory’) Stage 2 (‘Confirmatory’) First patient dose: 4Q 2023 22

Paxalisib in Atypical Teratoid / Rhabdoid Tumor Monotherapy showed activity in vivo models Paxalisib monotherapy slowed tumor growth and extended survival High unmet need in mice bearing AT/RT orthotopic xenograft tumors BT12 CHLA06 • Atypical Teratoid /Rhabdoid Tumors 100 100 Control Control (AT/RT) are the most common Paxalisib Paxalisib 75 75 malignant brain tumors of infancy 50 50 25 25 • Activation of the PI3k-Akt-mTOR 0 0 pathway is commonly observed in 0 20 40 60 80 0 10 20 30 40 50 Days after injection Days after injection patients with AT/RT • There are no FDA approved Data on additional combination treatments published at AACR 2023 therapies. Current standard of care are surgery, chemotherapy and With nucleoside analog, gemcitabine radiation • Increased apoptosis and synergized to decrease AT/RT cell growth • Further extended median survival in CHLA-266 orthotopic tumors With MEK inhibitor, mirdametinib • Reduced AT/RT growth and viability (Bliss synergy score 16.77) • Induced high levels of apoptosis and cell senescence • Decreased mTOR and MAPK pathway activation in mice bearing AT/RT orthotopic tumors Source: AACR 2022 & ISPNO 2022 Poster Presentations 23 Probability of Survival Probability of Survival

Brain metastases 24

Summary of Brain Metastases Clinical Studies Underway Registration Indication Phase N Status Sponsor Secondary (Metastatic) Brain Cancer Brain Metastases NCT04192981 I Up to 36 Recruiting (combination with radiotherapy) Breast Cancer Brain Metastases NCT03765983 II Up to 47 Recruiting (combination with trastuzumab) Brain Metastases NCT03994796 II 50 Recruiting (‘Alliance’ multi-drug study) 25

Paxalisib in Brain Metastasis PI3K pathway mutations are common in brain metastases and associated with a worse prognosis No Yes PIK3CA mutation Yes No CNS failure after SRS CNS failure after WBRT +PIK3CA mutations at 1 yr –PIK3CA mutations at 1 yr CNS failure after 48 (26-67) 30 (21-40) WBRT, % (95% CI) CNS failure after 16 (5-33) 7 (CI 4-10) SRS, % (95% CI) CI, confidence interval. SRS, stereotactic radiosurgery. WBRT, whole-brain radiation therapy. Lockney NA, et al. Int J Radiat Oncol Biol Phys. 2018;101(4):833-844. 26

Paxalisib in Brain Metastasis Phase I trial’s interim analysis showed encouraging clinical activity of paxalisib in combination with radiation therapy OVERALL STUDY DESIGN Additional 12 patients 12 patients enrolled (9 evaluable, 3 did not complete protocol treatment) Stage 2 (‘Confirmatory’) Stage 1 (‘Exploratory’) Interim Analysis Best Observed Response • The most common histology was breast cancer • The Maximum Tolerated Dose of paxalisib when combined with cranial RT has been established • Robust response with all evaluable patients experiencing partial or complete response per RANO-Brain Mets criteria within 3 months of protocol therapy Source: Jonathan Yang, et al, Neuro-Oncology Advances, 2022 27

Paxalisib in Brain Metastasis Phase II trial to evaluate efficacy with trastuzumab in BCBM patients OVERALL STUDY DESIGN Rationale of conducting the study • The PI3K/Akt/mTOR is an Cohort A: Single-arm, two-stage important pathway in HER2- (~37 patients) positive breast cancer brain Ongoing Treatment: Paxalisib Study will take ~3 metastases (BCBM). + Herceptin years to complete Cohort B: Pre-surgical window • Mutations in PIK3CA loss are (~10 patients) associated with trastuzumab resistance. • This single-center, phase II study Primary Endpoints: progression-free survival at six months (PFS6) and correlation 1 aims to evaluate the efficacy of the between p-4EBP1 inhibition in brain tumor tissue and PDX model response combination of paxalisib with 2 Secondary Endpoints: overall survival, safety and patient-reported outcomes trastuzumab for the treatment of CNS metastases in BCBM patients 28

Paxalisib in Brain Metastasis Genomically guided phase II study of multiple therapies in patients with brain metastases Rationale of conducting the study Abemaciclib • Approximately 30% of patients Eli Lilly Completed Breast cancer CDK mutation Graduation to Stage 2 with metastatic cancer develop brain metastases (Aug 2022) brain metastases • They have limited treatment Lung cancer brain Paxalisib Ongoing PI3K mutation options and an average survival metastases Recruiting patients Kazia Therapeutics range of 3 to 27 months • Variations in the genetic NTRK/ROS1 Other cancers Ongoing profiles of tumors in the same Recruiting patients brain metastases mutation location can lead to different Entrectinib Genentech responses to treatment Additional mutations to be evaluated in future 29 Depending on genetic mutation of cancer

Primary CNS lymphoma 30

Paxalisib in Primary CNS lymphoma Phase II trial to evaluate safety and efficacy of paxalisib in PCNSL Preliminary results anticipated 2H23 OVERALL STUDY DESIGN Rationale of conducting the study • PCNSL is a subtype of lymphoma Ongoing 25 patients with recurrent Treatment: paxalisib Last patient in that exclusively occurs in the or refractory PCNSL for up to 24 months (anticipated): 1H 2024 brain and CNS • PI3K inhibitors are effective for Results will be compared to relevant historical lymphoma outside the brain, but controls for the patient population enrolled in not for PCNSL because they the trial cannot cross the blood-brain barrier 1 • Paxalisib is the only PI3K inhibitor Primary Endpoint: objective response rate in development that can cross the 2 Secondary Endpoints: progress free survival, safety, overall survival blood-brain barrier, making it a unique candidate for treating PCNSL Source: NCT04906096 31

Other solid tumors 32

Paxalisib in Metastatic Melanoma Paxalisib showed potent single agent activity in an in vivo melanoma model Tumor Volume (Activity) Animal Weight (Tolerability) Survival (Efficacy) Source: AACR 2023 abstracts 33

Paxalisib in Metastatic Melanoma Paxalisib showed potential as therapeutic strategy in refractory melanoma Paxalisib blocked proliferation in vitro (cell confluence assay) Unmet need • Melanoma is the 5th most common cancer for men & women in the U.S. • Approximately 50% of all melanomas harbor an activating BRAF mutation. • Targeted therapy options for Paxalisib improved survival of BRAF-mutant mouse melanoma, and reduced BRAF-mutant melanoma exist, growth of dabrafenib/trametinib resistant melanoma PDX in vivo but most patients will experience primary or YUMM3.2 Kaplan-Meier Survival Curve MTG004 Tumor Volume secondary resistance • The five-year survival rate of stage IV melanoma remains at 30%, highlighting the need for new therapeutics to treat this disease. Source: AACR 2023 abstracts 34

Paxalisib – Potential Paths to Registration Multiple opportunities to become a marketed product Diffuse Midline Gliomas Initial data from • Potential path to accelerated approval via phase II study ongoing phase II study with ONC201 • Existing Rare Pediatric Disease Designation 3Q CY2023 creates possibility of priority review voucher Glioblastoma Final data from • Potential path to approval via first stage of GBMA AGILE study Paxalisib ongoing GBM AGILE pivotal study • Existing Fast Track Designation allows for 2H CY2023 greater consultation with FDA Brain Metastases Potential launch of • Design of potential registration study in registration study combination with whole brain radiotherapy is under discussion with key opinion leaders CY2024 35

Second Drug in Clinical Trials EVT801 has potential in a wide range of cancers Future Phase II Future Pivotal Explore EVT801 as Study Study an anti-angiogenic therapy, likely in Monotherapy Monotherapy tumours that express high ONGOING One or more solid One or more solid VEGFR3 Phase I Study tumours tumours Monotherapy Advanced solid tumours Future Phase Ib Future Pivotal Explore EVT801 in Study Study combination with immuno-oncology IO Combination IO Combination therapies such as Initial Data Keytruda and Expected One or more solid One or more solid Opdivo 2H CY2023 tumours tumours 36

Board and Management Team Extensive experience in drug development Board of Directors Management Team Scientific Advisory Board Iain Ross Priscilla Brastianos, MD Dr John Friend Chairman of the Board Chief Executive Officer Bryce Carmine Karen Krumeich John de Groot, MD Independent Director Chief Financial Officer Anna Sandham Alan Olivero, PhD Steven Coffey Corporate Secretary Independent Director Patrick Y Wen, MD Ebru Davidson Independent Director 37

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