March 2026 Zervimesine: a Once-daily Oral Therapeutic Advancing Toward Phase 3

2 FORWARD-LOOKING STATEMENTS This presentation contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements contained in this presentation, other than statements of historical facts or statements that relate to present facts or current conditions, including but not limited to, product candidates, including zervimesine, also known as zervimesine, and any expected or implied benefits or results, including that initial clinical results observed with respect to zervimesine will be replicated in later trials, and our clinical development plans, including statements regarding our clinical studies of zervimesine and our regulatory plans, expectations regarding potential patient populations, expectations regarding our patent portfolio, and our expected cash runway, are forward-looking statements. 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3 • Executive summary • Zervimesine MoA • Clinical programs • Phase 2 results • Comparison to published results Presentation Roadmap Financials Geographic Atrophy • Phase 2 results • Neuropsychiatric signals with no motor impairment • FDA discussion • Phase 2 results in mild-mod AD • p-tau217 Relevance • Phase 2 in MCI/early • FDA discussion Alzheimer’s Disease DLB Psychosis Corporate Introduction • Summary • Financials • Questions

4 Over $170M in grants from NIH & others substantially funded development through Phase 2 • Potential first-to-market for DLB psychosis - Majority of DLB patients experience psychosis - Psychotic symptoms result in higher HC costs and institutionalization - No drugs approved; off label use limited by side effects • Zervimesine treatment stabilized psychotic symptoms in Phase 2 - DLB psychotic symptoms slowed by 102% vs placebo (NPI-4) - Disease-modifying MoA expected to result in sustained treatment effect • Well tolerated safety profile in over 450 people treated to date - Modest side effect profile for use in aging population • Oral QD administration - No required imaging surveillance - ARIA unexpected based on MoA • Robust intellectual property through 2040 with PTE ARIA: amyloid-related imaging abnormalities; MOA: mechanism of action; PTE: patent term extension