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本報告書には、当社の最終市場、新製品およびサービスの導入を含む成長機会、当社の事業、製品およびサービスの地位と強み、当社の製品とソリューションに対する市場の需要と採用、顧客のニーズに対応し業界の要件を満たす当社の製品とソリューションの能力に関する記述を含むがこれらに限定されない、将来の見通しに関する記述が含まれています、顧客体験の向上、差別化された製品ソリューションの提供、生産性向上の推進、成長を最大化するための製品プラットフォームの活用、製造インフラ、研究開発、アプリケーションおよびソリューション・ポートフォリオの拡大・改善を含む当社の投資、発展途上国および新興市場における当社の地位の拡大、確定給付制度への拠出、当社の確定給付型年金制度への拠出、当社の将来の実効税率、未認識税務ベネフィット、償還インセンティブ、営業活動から生み出されるキャッシュを含む流動性要件を満たす能力、新たな会計基準の適用による潜在的影響、補償義務、当社の売上高、購入コミットメント、資本支出、統合、マクロ経済および市場の状況、当社の最終市場の回復と健全性、季節性、製品構成、将来の業績、営業利益率、地理的分散、金利、インフレ圧力、現地の規制や制限など、リスクと不確実性を伴うものです。当社の実際の業績は、当社の年次報告書Form 10-KのパートI項目1Aおよび本Form 10-Kの再掲の他の箇所で説明されているものを含む様々な要因により、これらの将来見通しに関する記述で意図されている業績とは大きく異なる可能性があります。

Item 1.    Business

ライフサイエンス・診断薬市場部門は7つの分野で構成されています。オリゴベースの治療薬の原薬や、臨床およびライフサイエンス研究分野の顧客が細胞や分子レベルでサンプルを解析できるようにする試薬、機器、ソフトウェア、消耗品などのソリューションを提供しています。Agilent CrossLab セグメントは、ソフトウェアおよびラボ自動化ソリューションに加え、広範なサービスおよび消耗品ポートフォリオでラボ全体をカバーし、顧客の成果を向上させるよう設計されています。応用市場部門は、物質や製品の物理的・生物学的特性の同定、定量、分析を可能にする装置やソフトウェアなど、用途に特化したソリューションを提供しています。

加えて、当社は受注処理・サプライチェーン組織（以下「OFS」）を通じて、当社事業の受注処理・サプライチェーン業務を集中的に行っている。OFSは製造、エンジニアリング、戦略的調達のリソースを各事業に提供しています。当グループの各事業は、OFSとともに、財務、情報技術、法務、一部の調達サービス、職場サービス、人事などの分野で共有サービスを提供するグローバル・インフラストラクチャー組織によって支えられています。

製品の販売は主に直接販売だが、代理店、再販業者、メーカー代理店、電子商取引も活用している。2024年10月31日現在、世界中で約17,900人を雇用している。主な研究開発および製造拠点は、米国ではカリフォルニア州、コロラド州、デラウェア州、マサチューセッツ州、テキサス州、バーモント州、オーストラリア、カナダ、中国、デンマーク、ドイツ、イタリア、日本、マレーシア、シンガポール、英国にあります。

2024年10月31日現在、ライフサイエンス・診断薬市場セグメントでは約6,300人を雇用している。

ライフサイエンス・診断薬市場部門は、主に製薬・バイオ医薬品、診断薬・臨床、学術・官公庁市場に販売しています。また、化学・先端材料、食品、環境、法医学といった応用市場にも販売しています。

医薬品・バイオ医薬品市場この市場は、治療研究・発見、前臨床効果、薬物動態、安全性試験、臨床試験、治療薬製造、品質保証、品質管理の分野で、医薬品のバリューチェーン全体に参加する「営利企業」で構成されている。医薬品市場の中で、新薬や低分子原薬と呼ばれる低分子医薬品に重点を置く顧客もいる。また、ヒト用または動物用の生物学的製剤やバイオシミラー医薬品を対象とするバイオ医薬品市場もある。このバイオ医薬品の分類には、生物学的成分や生物学的有効成分を製造する顧客も含まれる。生物学的製剤の成分や有効成分には、モノクローナル抗体、抗体薬物複合体、融合・組み換えタンパク質、治療用タンパク質（サイトカインやインスリンなど）、ペプチド、オリゴヌクレオチド、細胞・遺伝子治療薬、ワクチンなどが含まれる。さらに、新規の標的治療法の急速な発展や、がん領域における有効性の向上と患者の層別化の必要性から、製薬会社は診断会社と提携し、新薬とともに有効な検査を市場に投入している。当社は、最先端の治療法（細胞治療や遺伝子治療など）に取り組むバイオ製薬企業を中心に、一連の研究ツールやコンパニオン診断薬の開発サービスを提供しています。さらに、オリゴヌクレオチドをベースとした治療法のための原薬受託開発・製造サービスも提供している。

BIOVECTRA社の買収により、抗体薬物複合体、高活性原薬、微生物発酵による原薬の製造など、標的治療薬のためのさらに専門的な製造能力を製薬企業に提供することができます。当社の核酸ソリューションとBIOVECTRA事業は、遺伝子編集治療薬のシングルソースを提供することができます。液体クロマトグラフィー（「LC」）および液体クロマトグラフィー質量分析（「LCMS」）事業は、ライフサイエンスおよび製薬研究を行う顧客が、生物学的に関連する代謝物、脂質、タンパク質、および細胞システムを調査し、基本的な生物学的プロセスや、がんおよびその他の疾患の発生および進行の根本的なメカニズムを理解することを可能にする装置を提供しています。この情報を利用して、新しい治療戦略や薬剤、新しい診断検査を開発することを目標としています。当社の質量分析技術は、基本的な細胞プロセスに関与する代謝物、脂質、タンパク質の個別または全クラスの同定および定量、ならびに疾患状態において定量的または定性的に変化する代謝物の解明、さらには疾患のバイオマーカーとして有用な代謝物の同定に利用されています。

診断と臨床市場ライフサイエンス・診断薬市場セグメントにおける診断薬・臨床市場の焦点は、顧客が臨床研究やルーチン検査を実施できるような機器、ソフトウェア、試薬、消耗品を提供することである。当社の高品質で自動化された病理組織染色プラットフォームとソリューションは、病院、医療センター、リファレンスラボにある大規模ラボで最も多く使用されている。市場の焦点は、主に北米、西欧、日本の成熟経済である。しかし、新興市場が人々の健康への支出を増やすにつれて、その構成は変わりつつある。ゲノミクス事業の臨床市場は、「営利目的の」リファレンス・ラボ、病院ラボ、分子診断会社など、患者検査を実施する複雑性の高い臨床ラボで構成されている。体外診断用医薬品と表示された検査キットを購入するラボもあるが、分子ベースの検査を独自に開発し、検証するラボも多い。このような検査機関では、分析物に特化した試薬が使用されることが多い。さらに、当社のSeahorse、xCELLigence、Novocyte、BioTekの各プラットフォーム技術は、単独で、あるいは質量分析計と組み合わせて、正常および疾患状態における根本的な細胞生理学と相互作用を理解するために、また新薬や治療薬が細胞の組成、機能、相互作用をどのように変化させるかを理解するために使用されています。さらに、当社のXCELLigenceおよびNovocyteテクノロジーは、免疫細胞反応（細胞毒性など）の特性評価および定量化に使用できます。当社のLCおよびLCMS事業は、臨床研究を行う顧客が生物学的に関連する代謝物、脂質、タンパク質、および細胞システムを調査し、基本的な生物学的プロセスや、癌およびその他の疾患の発生と進行の根本的なメカニズムを理解することを可能にする装置を提供しています。この情報を利用して、新しい治療戦略や薬剤、新しい診断検査を開発することを目標としている。

化学品と先端材料市場当社の製品とソリューションは、汎用化学品、特殊化学品、農薬、ファインケミカルの開発、製造、品質管理において、化学品セクター全体で使用されています。化学市場の顧客は、当社の製品を使用して、ラボの生産性と収益性を維持、最適化、向上させ、品質管理と環境・安全規制の遵守をサポートしています。石油上流探査および精製市場では、天然ガスや原油の成分分析、中間原料の分析、精製プロセスの検証と改善、ガソリン、燃料、潤滑油、その他の製品の全体的な品質確保に当社製品が使用されています。さらに、当社の製品は、半導体、バッテリー、特殊加工ポリマーや高分子材料などの先端材料のバリューチェーン全体にわたって、安全性、品質、コンプライアンスに関する試験をサポートするために使用されています。

食品市場当社の機器とワークフロー・ソリューションは、入荷検査、新製品開発、品質管理・保証、パッケージングなど、食品製造チェーン全体で使用されています。例えば、質量分析計のポートフォリオは食品中の汚染物質や残留農薬の分析に使用されています。また、病原体汚染、種の正確な確認、遺伝子組み換えの証拠など、食品の分析に関わる重要な食品安全市場もあります。

環境と科学捜査市場当社の機器、ソフトウェア、ワークフロー・ソリューションは、大気、水、土壌、固形廃棄物中の規制および非規制の化学汚染物質の実験室および現場分析などの用途で、環境市場で使用されています。環境産業の顧客には、あらゆるレベルの政府機関、工業・製造業、エンジニアリング・コンサルティング会社、商業試験所、公共・民間公益事業、大学などが含まれます。薬物検査や法医学研究所では、犯罪に関連した証拠の分析、スポーツ選手の身体強化薬物のスクリーニング、娯楽用薬物のサンプル分析、生物・化学兵器剤の検出・同定などの用途に、当社の機器、ソフトウェア、ワークフロー・ソリューションを使用しています。当社の装置の一部は、移動ラボでも使用されています。顧客には、地方、州、連邦、および国際的な法執行機関や衛生研究所が含まれます。

液体クロマトグラフィー（「LC」）システムとコンポーネント、液体クロマトグラフィー質量分析（「LCMS」）システム、病理学、細胞分析、コンパニオン診断、ゲノミクス、受託開発・製造組織、生体分子分析。

液体クロマトグラフ、高性能液体クロマトグラフ（HPLC）、超高性能液体クロマトグラフ（UHPLC）は、液体混合物の分子を分離し、存在する分子の量と同一性を決定するために使用されます。Agilent LC ポートフォリオは、大部分がモジュール構造になっており、分析システムや分取システムとして構成することができます。これらのシステムは、メソッド開発、マルチメソッド/ウォークアップ、大容量/ハイスループット、多次元LCなど、高度に洗練された自動ワークフローソリューションに段階的にアップグレードすることができ、アプリケーションベースのアナライザ（バイオ分子分離、キラル分析、サイズ排除クロマトグラフィなど）に拡張することもできます。液体クロマトグラフィーのリーダーとして、当社は新しいHPLCカラム、新しいサービス、継続的な装置とソフトウェアの製品強化により、アプリケーション領域を拡大し続けています。

質量分析計（「MS」）は、分子質量と、分子を分解したときに生じるフラグメントイオンの特徴的な質量パターンに基づいて化合物を同定し、定量する。MSは、農薬のような低分子から、無傷のタンパク質やその他の生物体のような高分子まで、幅広い分析対象物を分析する上で重要なツールです。液体クロマトグラフィー（「LC」）は、化合物を分離してMSシステムに導入するために一般的に使用されます。当社のLCMSポートフォリオには、シングル四重極、トリプル四重極、飛行時間型、四重極飛行時間型という4つの主要なアナライザータイプを中心に構築された装置があります。当社は近年、性能、感度、精度、堅牢性、使いやすさ、オンボードインテリジェンスの向上に重点を置き、質量分析ポートフォリオを大幅に拡充しました。

この分野は、一次がん診断と高度がん診断の両方をターゲットとした抗体、試薬、機器、ソフトウェアからなるソリューションで、組織ベースのがん診断のための日常臨床ソリューションで構成されています。当社のCoverStainerおよびArtisanベースの製品ファミリーは、ヘマトキシリン・エオジン染色による一次がん診断、およびさらなる洞察と潜在的な発がん性組織の検出のための特殊染色を対象としています。Dako OmnisおよびAutostainerをベースとする免疫組織化学ソリューションおよびインスタントクオリティ蛍光in situハイブリダイゼーション技術は、タンパク質および遺伝子発現の調査を通じて高度な腫瘍タイピングを提供します。これらの製品にはコンパニオン診断検査も含まれ、特定の標的治療が最も有効な患者の同定に役立ちます。当社のバルク抗体事業は、体外診断薬メーカー、バイオテクノロジー企業、製薬企業と提携し、抗体を原料として提供するとともに、関連するさまざまなアッセイ開発サービスやソリューションを提供しています。お客様の臨床に関連するいくつかの分野で事業を展開し、比濁法、ゲル法、化学発光免疫測定法などの複数の技術に取り組んでいます。フローサイトメトリー試薬の分野では、特に血液がんに焦点を当て、日常的ながん診断に携わる臨床検査室に試薬とキットを直接提供している。

当社の細胞分析ツールは、代謝プロファイル分析、リアルタイムの細胞インピーダンス測定、および従来のサイトメトリー技術を通じて、細胞シグナル伝達経路、一般的な細胞機能および挙動を研究するために使用されます。細胞の挙動や機能を明らかにすることは、正常な挙動と疾患状態、疾患の進展、治療に対する反応を理解する上でますます重要なステップとなっており、研究者は創薬のより的を絞ったアプローチ、ひいてはより効果的な治療法を得ることができます。当社の細胞分析ポートフォリオには、細胞分析プレートベースアッセイ、フローサイトメーター、リアルタイムセルアナライザー、マイクロプレートリーダー、セルイメージングシステムおよび関連消耗品が含まれます。

コンパニオン診断薬事業では、多くの大手製薬企業と提携し、特定の標的治療から最も恩恵を受ける可能性の高い患者を特定するために使用される可能性のある新たな薬理診断薬の開発に取り組んでいます。製薬企業の医薬品開発プロセスの各段階（前臨床試験の初期段階から商業的上市活動まで）をサポートしています。コンパニオン診断薬は、正確で効果的なスコアリングと解釈のガイドラインを備えた、臨床的に適切で有効な検査を開発してきた実績があり、世界各国の市場で規制当局の承認を得ることができます。

       

Item 2. Properties