QIAGEN exceeds Q3 2025 outlook, raises FY 2025 adj. EPS target, announces Parse acquisition and $500 million share repurchase

•Q3 2025 results: Net sales of $533 million (+6% at actual rates); diluted EPS $0.60

◦Core sales +6% CER (constant exchange rates) driven by QIAstat-Dx (+11% CER), QuantiFERON (+11% CER) and Sample technologies (+3% CER)

◦Solid adjusted operating income margin at 29.6%

◦Adjusted diluted EPS $0.61 ($0.61 CER), above outlook for at least $0.58 CER

◦Ongoing strong operating cash flow of $165 million

•Full-year 2025 outlook reaffirmed for net sales growth of about 4-5% CER (about 5-6% CER core sales) and raises adj. diluted EPS target to about $2.38 CER

•Acquisition of Parse Biosciences expands Sample technologies portfolio into the single-cell market, capturing AI-driven growth opportunities in this fast-expanding area

•$500 million synthetic share repurchase approved at AGM 2025 to be completed in early January 2026 as QIAGEN delivers ahead of plan to return $1 billion by end-2028

•After six years as CEO, Supervisory Board and Thierry Bernard agree on timing for transition, and for Thierry Bernard to step down after successor is appointed

Venlo, the Netherlands, November 4, 2025 - QIAGEN N.V. (NYSE: QGEN; Frankfurt Prime Standard: QIA) today announced results for the third quarter of 2025 and reaffirmed its outlook for solid profitable growth while raising its profitability targets.

QIAGEN reaffirmed its FY 2025 outlook for net sales growth of about 4-5% CER (about 5-6% CER core sales excluding divestments) and raised its adjusted diluted EPS target to about $2.38 CER (previously about $2.35 CER). QIAGEN also expects an adjusted operating income margin of about 29.5% (about 30% CER) in 2025 while absorbing headwinds from currency movements and tariffs.

QIAGEN also announced two strategic initiatives to strengthen its Sample technologies portfolio and enhance shareholder value. The acquisition of Parse Biosciences provides entry into the rapidly growing single-cell market. QIAGEN also announced plans to complete a $500 million synthetic share repurchase in early January 2026 to further increase shareholder returns, bringing total returns to more than $1 billion since 2024 and well ahead of its 2028 goal.

“QIAGEN continues to deliver in a challenging environment, with another quarter of results above our outlook and among the fastest growth rates in the industry," said Thierry Bernard, CEO of QIAGEN. "We are pleased with the sustained growth from QIAstat-Dx and QuantiFERON, along with solid momentum in Sample technologies as we prepare to launch three new instruments. The acquisition of Parse Biosciences is an excellent strategic fit, strengthening our leadership in Sample technologies by providing access to the high-growth single-cell market and the ability to offer solutions to drive large-scale AI-driven biology. It reflects our commitment to invest in innovation offering accretive returns and expand our addressable markets. As we update our targets for 2025, we are moving ahead on our ambitions to deliver solid profitable growth,” he said.

“Our strong profitability and cash generation are allowing QIAGEN to step up shareholder returns," said Roland Sackers, CFO of QIAGEN. "With the execution of the $500 million repurchase in January 2026 that shareholders approved at our last Annual General Meeting, we are returning more than $1 billion to shareholders well ahead of our 2028 goal.

We remain focused on generating the highest returns and are reviewing how to increase this target while also strengthening our portfolio through organic investments and targeted acquisitions such as Parse. We anticipate that our ongoing capital allocation decisions will bring our leverage ratio toward the industry average of about 2x in 2026."

Please refer to accompanying tables in this release for full income statement information and a reconciliation of reported to adjusted figures.

(1) Reported diluted EPS for 9M 2024 based on basic shares of 222.7 million. Weighted number of diluted shares (9M 2024: 224.9 million).

•Sales: Q3 2025 net sales rose 6% over Q3 2024, with results at CER up 5% despite currency headwinds. Core sales excluding discontinued products increased 6% CER over the year-ago period. Diagnostic solutions led the performance among product groups with 4% CER growth (8% CER core growth), followed by Sample technologies growing 3% CER and Genomics / NGS sales rising 9% CER. Consumables and related revenues rose 6% CER, while instrument sales declined 7% CER amid cautious Life Sciences spending.

•Operating income: Q3 2025, operating income rose 15% to $129 million from the year-ago period, with results in Q3 2025 including $5.2 million of pre-tax charges related to the efficiency program initiated in 2024. Adjusted operating income, which excludes various charges and other in both periods, rose 6% to $158 million, with the adjusted operating income margin steady at 29.6% of sales compared to Q3 2024. On a constant exchange rate basis, the margin rose to 30.0%. These results reflected the solid business expansion, ongoing efficiency initiatives and the discontinuation of NeuMoDx. The adjusted gross margin declined to 65.6% from 66.5% in Q3 2024 as underlying margin improvements were more than offset by tariffs. R&D investments rose to 9.2% in Q3 2025 from 8.9% in the year-ago period, in line with the target for about 9-10%. Sales and marketing expenses were 21.2% of sales, down from 22.2% in Q3 2024 amid active customer engagement and cost management. General and administrative expenses were slightly lower at 5.7% compared to 5.9% in the prior-year quarter, reflecting cost discipline while supporting strategic IT upgrades such as the SAP migration.

•Earnings per share (EPS): Diluted EPS for Q3 2025 was $0.60, up from $0.44 in Q3 2024. Adjusted diluted EPS was $0.61 ($0.61 CER), exceeding the outlook of at least $0.58 CER. For Q3 2025, the adjusted tax rate was 18%, consistent with the quarterly estimate, while the diluted share count of 218.5 million was also in line with the outlook.

•Sample technologies: Sales in Q3 2025 rose 3% CER to $170 million, driven by solid consumables growth compared to the prior-year period, particularly from growth in automated kit sales at a double-digit CER rate. Instrument sales were slightly lower than in Q3 2024, but reflected continued good placements of QIAsymphony, QIAcube Connect and EZ2 Connect systems amid a challenging customer spending environment. By region, the Americas and EMEA delivered growth, offsetting a decline in Asia-Pacific/Japan driven by weaker trends in China.

•Diagnostic solutions: Sales rose 4% CER in Q3 2025 to $209 million, with core sales up 8% CER excluding the discontinued NeuMoDx system. Consumables grew at a mid-single-digit CER rate, while instrument sales were lower than in Q3 2024. QIAstat-Dx led the performance with 11% CER growth, driven by strong instrument placements and double-digit consumables growth across all syndromic panels. QuantiFERON latent TB sales grew 11% CER, supported by ongoing conversion from the skin test and broader market expansion across all regions. Companion diagnostic revenues rose more than 20% CER in Q3 2025 due to progress from an expanding range of collaborations with leading pharmaceutical partners.

•PCR / Nucleic acid amplification: Sales in Q3 2025 were $75 million, unchanged at CER compared to the prior-year period. QIAcuity delivered growth as expanding consumables sales more than offset lower instrument sales impacted by cautious Life Sciences spending. Other PCR consumables sales fell year-on-year, but included gains in the Human ID / Forensics portfolio.

•Genomics / Next-generation sequencing (NGS): Sales rose 9% CER to $61 million compared to Q3 2024. QIAGEN Digital Insights (QDI) bioinformatics sales grew at a double-digit CER rate, reflecting strong underlying demand and first-time contributions from the Genoox acquisition completed in mid-2025. Consumables sales of universal NGS panels for use on any sequencer also increased over Q3 2024.

•Other: Sales in this category included a modest contribution from surcharges related to tariffs introduced in 2025.

•Net cash from operating activities was $466 million for the first nine months of 2025 compared with $482 million in the same period of 2024. Results for the 2025 period included about $45 million in cash restructuring payments for the efficiency program initiated in 2024 and benefited from lower working capital requirements and ongoing efforts to optimize cash generation. Free cash flow was $336 million in the first nine months of 2025 compared to $364 million in the year-ago period, reflecting the 2025 cash restructuring payments and higher investments in property, plant and equipment for projects such as the SAP system upgrade compared to 2024.

•As of September 30, 2025, cash, cash equivalents and short-term investments totaled $1.7 billion compared with $1.2 billion at year-end 2024. Key cash flow items during the 2025 period included the return of approximately $300 million to shareholders in January through a synthetic share repurchase, which reduced outstanding shares by 6.2 million (about 2.8%). In July 2025, the first annual cash dividend of about $54 million was also paid to shareholders. Results for Q4 2025 are expected to include cash payments of about $500 million for the anticipated early repayment of the 2027 convertible notes and the $225 million cash payment for the Parse acquisition. For 2026, QIAGEN currently anticipates about $500 million of cash payments for the share repurchase.

QIAGEN announced on November 4 that the Supervisory Board and Thierry Bernard have agreed that this is the right time to initiate a leadership transition, and that he will step down as CEO and Managing Director once a successor is appointed. The Supervisory Board, supported by an executive search firm, has initiated a process to identify, evaluate and appoint a successor from both internal and external candidates.

Thierry Bernard, 61, joined QIAGEN in 2015 and has served as CEO since 2019. He will continue in his role until a successor is appointed to ensure a smooth transition and continuity, and will not stand for re-election as a member of the Managing Board at the Annual General Meeting in June 2026.

“On behalf of the Supervisory Board and the entire QIAGEN team, I want to thank Thierry for his leadership and dedication to QIAGEN,” said Stephen H. Rusckowski, Chairman of the Supervisory Board at QIAGEN. “During his tenure, Thierry positioned QIAGEN to deliver a consistent performance, strengthen its portfolio across the Life Sciences and diagnostics, and create a foundation for solid profitable growth. The Supervisory Board is focused on building on this momentum and appointing a successor who will help drive QIAGEN’s next phase of performance and value creation.”

“It is a privilege to serve this remarkable company and work with such exceptional people around the world,” said Thierry Bernard. “Together we have transformed QIAGEN and achieved consistently strong results in a challenging global environment. I believe this is the right time for a transition that will best support QIAGEN’s continued success, and remain confident that QIAGEN is well positioned to deliver on its 2028 ambitions and continue creating sustainable value.”

QIAGEN announced on November 4 plans to acquire Parse Biosciences, a privately held leader in single-cell RNA research based in Seattle, Washington. The acquisition of Parse, whose products are used by more than 3,000 laboratories in over 40 countries, will significantly expand QIAGEN’s Sample technologies portfolio into the fast-growing single-cell market with highly scalable chemistry designed to research involving millions and billions of cells. Parse’s scalable Evercode chemistry is also expected to accelerate growth in the QIAGEN Digital Insights (QDI) bioinformatics business, enabling customers to generate, process and interpret AI-driven single-cell data more efficiently and at much greater scale. QIAGEN will acquire Parse for approximately $225 million in cash, with Parse equity holders eligible for additional milestone payments of up to $55 million. The transaction is expected to be completed in December 2025 and not provide any meaningful contributions for the year. For 2026, Parse is expected to contribute about $40 million in sales to QIAGEN (approximately two percentage points of growth), with strong double-digit sales growth expected in subsequent years. The transaction is expected to be dilutive to adjusted EPS by about $0.04 in 2026 and accretive starting in 2028.

QIAGEN announced on November 4 a $500 million synthetic share repurchase combining a direct capital repayment with a reverse stock split. The program, authorized by the Supervisory Board following approval by shareholders at the Annual General Meeting in June 2025, is expected to be completed on or about January 7, 2026. With this transaction, QIAGEN will deliver approximately $1.15 billion in total returns to shareholders since 2024, well ahead of its $1 billion target for the end of 2028. The repurchase reflects QIAGEN's strong operational profitability and disciplined capital allocation framework designed to enhance shareholder returns while maintaining flexibility for targeted investments to support sustainable long-term growth.

QIAGEN has a long-standing capital allocation strategy focused on directing resources to the highest return opportunities, including (1) organic investments into the business, particularly R&D and commercial channels; (2) targeted M&A opportunities, as demonstrated by the acquisition of Parse; and (3) increasing returns to shareholders through share repurchases and an annual dividend. Based on the Parse acquisition and the $500 million synthetic share repurchase set for completion in January 2026, as well as plans for more disciplined capital allocation, QIAGEN expects its leverage ratio (net debt to adjusted EBITDA) will move toward the industry average of about 2x in 2026.

QIAGEN is executing on targeted initiatives across its Sample to Insight portfolio to help customers around the world advance science and improve healthcare.

•Sample technologies: QIAGEN recently marked the 4,000th placement of QIAcube Connect, reaffirming its leadership in automated sample processing. Together with the earlier-generation system, more than 12,800 QIAcubes have now been installed worldwide. QIAcube Connect automates over 80 kits and 140 standard protocols, which can be expanded to more than 3,000, offering remote monitoring, pre-run safety checks and digital connectivity through QIAsphere.

•QIAstat-Dx: In September 2025, QIAGEN received U.S. FDA clearance for QIAstat-Dx Rise, a high-throughput version of its flagship syndromic testing platform. The system automates up to 18 tests simultaneously, expanding access to rapid multiplex PCR diagnostics in hospitals and reference labs. The same system was launched earlier for customers in Europe.

Full-Year 2025: QIAGEN has reaffirmed its outlook for net sales growth of about 4-5%, including about 5-6% CER growth in the core business excluding revenues from discontinued products. Based on the strong performance to date in 2025, the target for adjusted diluted earnings per share (EPS) has been increased to about $2.38 CER (previously about $2.35 CER), representing a 9% CER increase from $2.18 in 2024. This outlook reflects continued macroeconomic challenges, including headwinds from U.S. import tariffs and the U.S. government shutdown. The adjusted operating income margin is expected to be about 29.5% (about 30% CER) for 2025 compared to 28.7% in 2024. Based on exchange rates as of November 1, 2025, currency movements against the U.S. dollar are expected in FY 2025 to have a positive impact on net sales of about one percentage point, but an adverse impact of about $0.02 per share on adjusted diluted EPS.

Q4 2025: Net sales are expected to remain steady at CER rates (core sales growth of about 2% CER) compared to $521 million in Q4 2024. This outlook reflects ongoing macroeconomic challenges, including the impact of the U.S. government shutdown continuing until the end of the year. Adjusted diluted EPS is expected to be about $0.60 CER compared to $0.61 in the year-ago period. Currency movements against the U.S. dollar are expected for Q4 2025 to have a positive impact on net sales of about one percentage point but an adverse impact of about $0.01 on adjusted diluted EPS.

A conference call is scheduled for Wednesday, November 5, 2025, at 15:30 Frankfurt Time / 14:30 London Time / 9:30 New York Time. A live audio webcast will be available in the Investor Relations section of the QIAGEN website (www.qiagen.com), with a recording accessible after the event. The accompanying presentation will be published in advance under "Events and Presentations" in the same section.

Use of adjusted results

QIAGEN reports adjusted results and constant exchange rate (CER) measures, along with other non-GAAP financial metrics, to provide deeper insight into business performance. These include core sales (excluding discontinued products), adjusted gross margin and profit, adjusted operating income and expenses, adjusted operating income margin, adjusted net income, adjusted income before taxes, adjusted diluted EPS, adjusted EBITDA, adjusted tax rate, and free cash flow. Free cash flow is calculated as cash flow from operating activities less capital expenditures for property, plant and equipment. Adjusted results are non-GAAP measures that QIAGEN views as complementary to GAAP-reported results. They exclude items considered outside of ongoing core operations, subject to significant period-to-period fluctuation, or that reduce comparability with competitors and historical performance. QIAGEN also uses these non-GAAP and constant currency measures internally for planning, forecasting, reporting, and employee compensation purposes. These metrics enable consistent comparison of current and past performance, which QIAGEN has historically presented on an adjusted basis.

QIAGEN N.V., a Netherlands-based holding company, is a global leader in Sample to Insight solutions that enable customers to extract and analyze molecular information from biological samples containing the building blocks of life. Our Sample technologies isolate and process DNA, RNA and proteins from blood, tissue and other materials. Assay technologies prepare these biomolecules for analysis, while bioinformatics support the interpretation of complex data to deliver actionable insights. Automation solutions integrate these steps into streamlined, cost-effective workflows. QIAGEN serves more than 500,000 customers worldwide in the Life Sciences (academia, pharmaceutical R&D and industrial applications such as forensics) and Molecular Diagnostics (clinical healthcare). As of September 30, 2025, QIAGEN employed approximately 5,700 people across more than 35 locations. For more information, visit www.qiagen.com.

Certain statements in this press release may constitute forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended. These statements, including those regarding QIAGEN’s products, development timelines, marketing and/or regulatory approvals, financial and operational outlook, growth strategies, capital allocation strategies, collaborations and operating results (such as expected net sales and adjusted diluted earnings), the CEO transition plan, the acquisition of Parse Biosciences, including the timing and expected benefits thereof, and the synthetic share repurchase, including the timing and expected benefits thereof, are based on current expectations and assumptions. However, they involve uncertainties and risks. These risks include, but are not limited to: challenges in managing a successful CEO transition and successor search while providing operational continuity and continued advancement of company strategy; challenges in managing growth and international operations (including the effects of currency fluctuations, tariffs, tax laws, regulatory processes and logistical dependencies); variability in operating results and the commercial development of products for customers in the Life Sciences and clinical healthcare markets; changes in relationships with customers, suppliers or strategic partners; competition and rapid technological advancement; developments or changes in the securities markets and fluctuations in the trading volume and market price of QIAGEN’s shares and the successful implementation of the synthetic share repurchase; QIAGEN’s ability to successfully close, integrate and achieve the expected benefits of its acquisition of Parse Biosciences, including fluctuating demand for QIAGEN’s products due to factors such as economic conditions, customer budgets and funding cycles; obtaining and maintaining regulatory approvals for our products; difficulties in successfully adapting QIAGEN's products into integrated solutions and producing these products; and protecting product differentiation from competitors. Additional risks and uncertainties may arise from market acceptance of new products, integration of acquisitions, governmental actions, global or regional economic developments, natural disasters, political or public health crises, and other “force majeure” events. There is also no guarantee that anticipated benefits from restructuring programs and acquisitions will materialize as expected. For a more complete discussion of risks and uncertainties, please refer to the “Risk Factors” section in our most recent Annual Report on Form 20-F and other reports filed with or furnished to the U.S. Securities and Exchange Commission.

(1) Reported diluted net loss per common share based on basic shares for 9M 2024 of 222.7 M. Adjusted diluted EPS calculated using
224.9 M diluted shares.

(a) Results include costs for acquisition projects, including the acquisition of GNX Data Systems Ltd. (doing business as Genoox) completed in May 2025. It also includes costs incurred in connection with streamlining operations and improving overall efficiency as well as costs related to various contemplated and completed acquisition projects and their subsequent integration.

(b) Adjustment includes the full impairment of an equity method investment.

(c) These items represent updates in QIAGEN's assessment of ongoing examinations or other tax items that are not indicative of the Company's normal future income tax expense.

Tables may contain rounding differences.

(1) The December 31, 2024 balances for the 'current portion of long-term debt' and 'long-term debt, net of current portion', and the corresponding balances of total current liabilities and total long-term liabilities, have been adjusted to correct the classification with respect to $498.4 million of the 2027 convertible notes previously classified as long-term which should have been classified as current under U.S. GAAP, based on a bondholder put date of December 17, 2025 on the $500.0 million aggregate principal amount of zero coupon Convertible Notes due in 2027.

(1) Free cash flow is a non-GAAP financial measure and is calculated from net cash provided by operating activities reduced by purchases of property, plant and equipment.

•Parse Biosciences is a fast-growing innovator in single-cell sample preparation, with technologies used in more than 3,000 labs across over 40 countries

•Acquisition strengthens QIAGEN’s presence in the rapidly growing single-cell market, accelerating growth across its industry-leading Sample technologies portfolio

•Parse provides Evercode, a highly differentiated instrument-free platform built for analyzing millions and billions of cells for large-scale AI-driven biology

•Single-cell market expected to nearly double by 2029, driven by AI-powered drug discovery and demand for high-scale, quantitative biological data

•Parse to be fully acquired for an upfront payment of approximately $225 million in cash and additional potential milestone payments, transaction expected to be completed in late 2025

Venlo, the Netherlands, and Seattle, Washington, November 4, 2025 – QIAGEN (NYSE: QGEN; Frankfurt Prime Standard: QIA) today announced it has entered into a definitive agreement to fully acquire Parse Biosciences, a leading provider of scalable, instrument-free solutions for single-cell research.

The acquisition will significantly expand QIAGEN’s Sample technologies portfolio into the fast-growing single-cell sequencing market with highly scalable chemistry designed to power research involving up to millions and billions of cells. Parse’s scalable chemistry is also expected to accelerate growth in the QIAGEN Digital Insights (QDI) bioinformatics business, enabling customers to generate, process and interpret AI-driven single-cell data more efficiently and at much greater scale, from the first sample to actionable insights.

Strategic fit with QIAGEN Sample technologies: Entering the age of single-cell AI

Single-cell analysis allows scientists to study the activity of genes in individual cells, revealing the driving mechanisms of health and disease. The global single-cell market is expected to grow from about $1.2 billion in 2024 to $2.1 billion by 2029, reflecting annual growth of about 10%. This expansion is being driven by AI-based drug discovery as pharmaceutical and biotechnology companies generate large-scale cellular datasets to train predictive models of biology.

Parse is distinctly positioned to capitalize on this trend with Evercode, a proprietary combinatorial barcoding platform. Evercode is highly differentiated by enabling large-scale projects to analyze millions and billions of cells, a capability lacking in other single-cell offerings. Parse’s technologies are supporting breakthroughs by generating the massive datasets required to power a new generation of discovery.

“The addition of the Parse team to QIAGEN will significantly strengthen our offerings in one of the most dynamic areas of life science,” said Thierry Bernard, CEO of QIAGEN. “Single-cell analysis is the key to understanding health and disease at a mechanistic level. By combining Parse with our Sample technologies portfolio and QDI bioinformatics offering, we can provide researchers with the tools to generate the massive datasets required to build predictive virtual cell models that fuel AI-based drug discovery. We are investing in areas that offer the highest returns and growth potential to create long-term value for QIAGEN and our stakeholders.”

“Parse was founded to make single-cell sequencing accessible to any lab,” said Alex Rosenberg, PhD, CEO and co-founder of Parse Biosciences. “As our team joins QIAGEN, we want to accelerate that mission and extend the reach of our technology to more customers around the world. QIAGEN’s strong commitment to Sample technologies and its global infrastructure make it an ideal partner for our next stage of growth.”

Parse’s technology is designed to profile more cells in less time, addressing the increasing demand among customers for massive-scale projects, particularly in pharma and academia.

Key advantages include:

•Instrument-free: Parse solutions do not require a specialized instrument, allowing for rapid customer adoption and use in any lab and creating a major differentiator in scalability.

•Data scale and quality: Parse has pioneered high-throughput single-cell analysis, highlighted by the Tahoe-100M dataset – the largest publicly available single-cell dataset to date comprising more than 100 million single-cell transcriptomes (the complete set of RNA molecules expressed in each cell).

•GigaLab service: Parse’s latest offering is GigaLab, a high-throughput service with a capacity of 2.5 billion cells per year. This service supports multi-million cell projects used in drug and target screens across therapeutic areas such as oncology, immunology and neurology, and is highly valued by pharmaceutical partners.

•Broad adoption: Parse’s products are used by over 3,000 labs globally, including all of the top 50 research institutions and top 10 pharma companies.

•Intellectual property: Parse holds an exclusive license to 36 granted University of Washington patents on split-pool combinatorial barcoding for all fields, providing broad protection for its proprietary technology.

QIAGEN will fully acquire Parse Biosciences for an upfront payment of approximately $225 million in cash, with Parse equity holders eligible for additional milestone payments of up to $55 million based on the achievement of targets over a multi-year period. The transaction, which is subject to clearance under the U.S. Hart-Scott-Rodino Antitrust Improvements Act and other customary conditions, is expected to be completed in December 2025 and not provide any meaningful contributions for the year. For full-year 2026, Parse is expected to contribute approximately $40 million in sales to QIAGEN (approximately two percentage points of growth), with sales expected to increase at a strong double-digit rate in subsequent years. The transaction is expected to be dilutive to adjusted earnings per share (EPS) by approximately $0.04 in 2026 and accretive beginning in 2028.

QIAGEN N.V., a Netherlands-based holding company, is the leading global provider of Sample to Insight solutions, enabling customers to extract and gain valuable molecular insights from samples containing the building blocks of life. Our Sample technologies isolate and process DNA, RNA and proteins from blood, tissue and other materials. Assay technologies prepare these biomolecules for analysis while bioinformatics software and knowledge bases can be used to interpret data to find actionable insights. Automation solutions bring these processes together into seamless and cost-effective workflows. QIAGEN serves over 500,000 customers globally in Life Sciences (academia, pharma R&D and industrial applications, primarily forensics) and Molecular Diagnostics for clinical healthcare.

As of September 30, 2025, QIAGEN employed approximately 5,700 people in over 35 locations worldwide. For more information, visit www.qiagen.com.

About Parse Biosciences

Parse Biosciences is a leading provider of scalable, chemistry-based single-cell solutions. Its proprietary Evercode™ platform enables instrument-free, high-throughput RNA workflows with unmatched flexibility and ease of use. The company also offers the cloud-based Trailmaker™ software suite for intuitive data analysis and GigaLab, a service platform capable of processing large-scale projects. Parse serves more than 3,000 customers in over 40 countries. Founded in 2018, Parse is headquartered in Seattle, Washington, and has about 110 employees. For more information, visit www.Parsebiosciences.com.

Certain statements in this press release may constitute forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended, including with respect to QIAGEN’s proposed acquisition of Parse Biosciences. These statements include those regarding the expected economic and operational benefits of the proposed transaction (including the acquired business’ expected future sales and sales growth rate, as well as the expected benefits and success of Parse Biosciences offerings), the expected timing of the closing of the proposed transaction, and the ability of the parties to complete the proposed transaction considering the various closing conditions. Additional forward-looking statements may include statements regarding QIAGEN's products, development timelines, marketing and/or regulatory approvals, financial and operational outlook, growth strategies, collaborations and operating results (such as expected net sales and adjusted diluted earnings). These statements are based on current expectations and assumptions. However, they involve uncertainties and risks. These risks include, but are not limited to: the expected benefits of the proposed transaction may not be realized; QIAGEN’s ability to successfully implement integration strategies for the acquired business within the expected timeframes; the proposed transaction not being timely completed, if at all; regulatory approvals required for the proposed transaction not being timely obtained, if at all, or being obtained subject to conditions; challenges in managing growth and international operations (including the effects of currency fluctuations, tariffs, tax laws, regulatory processes and logistical dependencies); variability in operating results and the commercial development of products for customers in the Life Sciences and clinical healthcare markets; changes in relationships with customers, suppliers or strategic partners; competition and rapid technological advancements; fluctuating demand for QIAGEN's products due to factors such as economic conditions, customer budgets and funding cycles; obtaining and maintaining regulatory approvals for our products; difficulties in successfully adapting QIAGEN's products into integrated solutions and producing these products; and protecting product differentiation from competitors. Additional risks and uncertainties may arise from market acceptance of new products, integration of acquisitions, governmental actions, global or regional economic developments, natural disasters, political or public health crises, and other "force majeure" events. There is also no guarantee that anticipated benefits from restructuring programs and acquisitions will materialize as expected. For a more complete discussion of risks and uncertainties, please refer to the “Risk Factors” section in our most recent Annual Report on Form 20-F and other reports filed with or furnished to the U.S. Securities and Exchange Commission.

Venlo, the Netherlands, November 4, 2025 – QIAGEN N.V. announces a plan to return up to approximately $500 million to shareholders through a synthetic share repurchase that combines a direct capital repayment with a reverse stock split.

QIAGEN has decided to implement the maximum $500 million value of the mandate given at the Annual General Meeting in June 2025, where shareholders gave virtually unanimous approval for the related resolutions. This approach is designed to return cash to shareholders in a more efficient way than through a traditional open-market repurchase program. It would also enhance earnings per share (EPS) through the reduction in outstanding shares. The synthetic share repurchase will become effective on or about January 7, 2026, and will be settled in line with market convention in the subsequent days.

This type of synthetic share repurchase involves the following three general steps:

(1)The par value of QIAGEN’s common shares (EUR 0.01 per share) will be increased through a transfer from the Share Premium Reserve (included in “Additional Paid-in Capital” on the Company’s balance sheet) to allow for the capital repayment to shareholders.

(2)A reverse stock split will consolidate shares.

(3)The par value will be reduced back to the original level of EUR 0.01 per share and the capital repayment will be paid out directly to shareholders (as of the record date, and where applicable after conversion into U.S. dollars).

Further information on this process will be announced before implementation.

QIAGEN N.V.

Hulsterweg 82

5912 PL Venlo

The Netherlands

ISIN: NL0015001WM6

John Gilardi, Tel: +49 2103 29 11711; pr@qiagen.com

Exhibit 99.4

Ad hoc Announcement according to Art. 17 Market Abuse Regulation

Venlo, the Netherlands, November 4, 2025 – QIAGEN N.V. (NYSE: QGEN; Frankfurt Prime Standard: QIA) announces that Thierry Bernard will step down as Chief Executive Officer and Managing Director once a successor is appointed.

The Supervisory Board and Thierry Bernard have agreed this is the right time to initiate a leadership transition at QIAGEN. The Supervisory Board, supported by an executive search firm, has initiated a process to identify, evaluate and appoint a successor from both internal and external candidates.

Thierry Bernard, 61, joined QIAGEN in 2015 and has served as CEO since 2019. He will continue in his role until a successor is appointed to ensure a smooth transition and continuity, and he will not stand for re-election as a member of the Managing Board at the Annual General Meeting planned for June 2026.

QIAGEN remains fully focused on executing its strategy, delivering on its 2025 outlook following a solid performance in Q3 2025 and advancing its 2028 ambitions for solid profitable growth. Updates on the CEO search and transition process will be provided as appropriate.

QIAGEN N.V.
Hulsterweg 82
5912 PL Venlo
The Netherlands

ISIN: NL0015002CX3

John Gilardi, Tel: +49 2103 29 11711; ir@qiagen.com