Comerica Incorporated RBC Capital Markets Financial Institutions Conference March 6, 2024 Jim Herzog Chief Financial Officer Peter Sefzik Chief Banking Officer Kelly Gage Director of Investor Relations Safe Harbor Statement This presentation includes forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995. In addition, Comerica may make other written and oral communications from time to time that contain such statements. All statements regarding Comerica's expected financial position, strategies and growth prospects as well as general economic conditions expected to exist in the future are forward-looking statements. The words, “anticipates,” “believes,” "contemplates," “feels,” “expects,” “estimates,” “seeks,” “strives,” “plans,” “intends,” “outlook,” “forecast,” “position,” “target,” “mission,” “assume,” “achievable,” “potential,” “strategy,” “goal,” “aspiration,” “opportunity,” “initiative,” “outcome,” “continue,” “remain,” “maintain,” "on track," “trend,” “objective,” “looks forward,” "projects," "models" and variations of such words and similar expressions, or future or conditional verbs such as “will,” “would,” “should,” “could,” “might,” “can,” “may” or similar expressions, as they relate to Comerica or its management, are intended to identify forward-looking statements. Comerica cautions that forward-looking statements are subject to numerous assumptions, risks and uncertainties, which change over time. Forward-looking statements speak only as of the date the statement is made, and Comerica does not undertake to update forward- looking statements to reflect facts, circumstances, assumptions or events that occur after the date the forward-looking statements are made. Actual results could differ materially from those anticipated in forward-looking statements and future results could differ materially from historical performance. In addition to factors mentioned elsewhere in this report or previously disclosed in Comerica's SEC reports (accessible on the SEC's website at www.sec.gov or on Comerica's website at www.comerica.com), actual results could differ materially from forward-looking statements and future results could differ materially from historical performance due to a variety of reasons, including but not limited to, the following factors: changes in customer behavior may adversely impact Comerica's business, financial condition and results of operations; unfavorable developments concerning credit quality could adversely affect Comerica's financial results; declines in the businesses or industries of Comerica's customers could cause increased credit losses or decreased loan balances, which could adversely affect Comerica; governmental monetary and fiscal policies may adversely affect the financial services industry, and therefore impact Comerica's financial condition and results of operations; fluctuations in interest rates and their impact on deposit pricing could adversely affect Comerica's net interest income and balance sheet; Comerica's transition away from the Bloomberg Short-Term Bank Yield Index could adversely affect its financial results; Comerica must maintain adequate sources of funding and liquidity to meet regulatory expectations, support its operations and fund outstanding liabilities; reduction in Comerica's credit ratings could adversely affect Comerica and/or the holders of its securities; the soundness of other financial institutions could adversely affect Comerica; security risks, including denial of service attacks, hacking, social engineering attacks targeting Comerica’s colleagues and customers, malware intrusion or data corruption attempts, and identity theft, could result in the disclosure of confidential information, adversely affect its business or reputation, and create significant legal and financial exposure; cybersecurity and data privacy are areas of heightened legislative and regulatory focus; Comerica’s operational or security systems or infrastructure, or those of third parties, could fail or be breached, which could disrupt Comerica’s business and adversely impact Comerica’s results of operations, liquidity and financial condition, as well as cause legal or reputational harm; Comerica relies on other companies to provide certain key components of its delivery systems, and certain failures could materially adversely affect operations; legal and regulatory proceedings and related financial services industry matters, including those directly involving Comerica and its subsidiaries, could adversely affect Comerica or the financial services industry in general; Comerica may incur losses due to fraud; controls and procedures may fail to prevent or detect all errors or acts of fraud; changes in regulation or oversight, or changes in Comerica’s status with respect to existing regulations or oversight, may have a material adverse impact on Comerica's operations; damage to Comerica’s reputation could damage its businesses; Comerica may not be able to utilize technology to develop, market and deliver new products and services to its customers; competitive product and pricing pressures within Comerica's markets may change; the introduction, implementation, withdrawal, success and timing of business initiatives and strategies may be less successful or may be different than anticipated, which could adversely affect Comerica's business; management's ability to maintain and expand customer relationships may differ from expectations; management's ability to retain key officers and employees may change; any future strategic acquisitions or divestitures may present certain risks to Comerica's business and operations; general political, economic or industry conditions, either domestically or internationally, may be less favorable than expected; inflation could negatively impact Comerica's business, profitability and stock price; methods of reducing risk exposures might not be effective; catastrophic events, including pandemics, may adversely affect the general economy, financial and capital markets, specific industries, and Comerica; climate change manifesting as physical or transition risks could adversely affect Comerica's operations, businesses and customers; changes in accounting standards could materially impact Comerica's financial statements; Comerica's accounting policies and processes are critical to the reporting of financial condition and results of operations and require management to make estimates about matters that are uncertain; Comerica's stock price can be volatile; and an investment in Comericas' equity securities is not insured or guaranteed by the FDIC. compliance with more stringent capital requirements may adversely affect Comerica; changes to tax law or regulations, or changes to administrative or judicial interpretations of tax law or regulations, could adversely affect Comerica; climate change manifesting as physical or transition risks could adversely affect Comerica's operations, businesses and customers; changes in accounting standards could materially impact Comerica's financial statements; Comerica's accounting policies and processes are critical to the reporting of financial condition and results of operations and require management to make estimates about matters that are uncertain; Comerica's stock price can be volatile; and an investment in Comericas' equity securities is not insured or guaranteed by the FDIC. 2©2024, Comerica Inc. All rights reserved.

3©2024, Comerica Inc. All rights reserved. Positioned for the Future Strong foundation & strategic actions create opportunity for enhanced returns over time The Right Business Strategy • Distinct value proposition for target customers with larger bank capabilities & smaller bank delivery • Leaning into commercial strengths while investing further in complementary fee & deposit generating products Diversified • Deliberate diversification across business lines limits exposure to any one sector or asset class • MSA-focused geographic strategy capitalizes on growth opportunities while limiting exposure to individual states or regions Favorable Earnings Trajectory • NII to benefit from maturing swaps & securities into 2025 • Prepared for lower rate environment • Demonstrated expense discipline through recent actions Strong Liquidity & Funding • Peer leading NIB mix • Low loan to deposit ratio • Abundant access to liquidity • Successful 1Q24 debt issuance, largest in our history Disciplined Credit • Track record of peer outperformance through cycles • Well-reserved relative to peers • ~40% of total CRE exposure is owner occupied • No NY rent-controlled multi-family exposure • Nominal office exposure (<2% of total CMA loans) Regulatory Preparedness • Prior experience under Enhanced Prudential Standards • At $86B of assets, current organic growth strategy provides runway • CET1 ex AOCI opt-out exceeded regulatory minimums at 12/31 • Strong liquidity position • Quantified operational cost to comply APPENDIX

Recent Awards & Recognition One of America’s Most JUST Companies by JUST Capital and CNBC America’s Most Responsible Companies America’s Greenest Companies America’s Greatest Workplaces Earned a score of 100 on the Human Rights Campaign Foundation’s 2023-2024 Corporate Equality Index (CEI) The Right Balance Positioned to effectively meet the unique needs of our target customers Experienced & tenured team delivering consistency to our relationships across markets & businesses Tailored solutions & customized product offerings to meet our customers needs Localized advice for our customers Industry expertise adding unique value to our customers Full suite of products & services including credit capacity, treasury management, & capital market solutions Community engagement recognizing we all play a role in advancing the markets & communities we serve 2023 Newsweek Honors ©2024, Comerica Inc. All rights reserved. 5 Commercial Bank 86% 10% 4% Commercial Bank Wealth Management Retail Bank 49% 6% 37% 8% Commercial Bank Wealth Management Retail Bank Other ©2024, Comerica Inc. All rights reserved. Diversified Businesses Unique & complementary model Loans1 Deposits2 1Average 4Q23 loans 2Average 4Q23 deposits 6 Wealth Management Deliver a first-class commercial solution as a “Leading Bank for Business” including a robust digital suite Grow Middle Market, Business Banking & Specialty Businesses in which we have expertise Generate capital- efficient fee income Focus on organic & other strategic growth opportunities Deliver a high level of service to customers across all touchpoints Provide important funding source for the Corporation in terms of size, granularity & deposit diversification Retail Bank Cohesive relationship strategy across our divisions unlocks the value of our franchise

Loan Update Positioned for responsible growth 1Q24 metrics through 2/29/24 are preliminary & subject to change. Quarterly and other shorter-duration results may not be representative of longer-duration performance due to business seasonality or other circumstances 1Comparisons of 1Q24 through 2/29/24 vs 4Q23 2Outlook as of 3/5/24 7©2024, Comerica Inc. All rights reserved. 53.5 55.4 54.0 52.8 51.5 30.0 40.0 50.0 60.0 1Q23 2Q23 3Q23 4Q23 1Q24 Thru 2/29 Loan Trends ($ in billions; average) Quarter-to-Date Trends Through 2/29 • ~$1.3B decrease in QTD average loans1 • Largest declines in Middle Market, Equity Funds Services & National Dealer Services • Largest increase in Commercial Real Estate • 1Q24 Outlook2: Expect average loan balances in line with prior 1Q guidance range 56.5 57.5 57.0 55.5 53.7 45% 46% 47% 47% 48% 4Q22 1Q23 2Q23 3Q23 4Q23 Utilization Loan Commitments Declined with Increased Selectivity (period-end: $ in billions) ©2024, Comerica Inc. All rights reserved. 1Q24 metrics through 2/29/24 are preliminary & subject to change. Source for peer data: S&P Global Market Intelligence & company press releases; for a comprehensive list of our peer group please see our 2023 Proxy Statement 1Comparisons of 1Q24 through 2/29/24 vs 4Q23 2Outlook as of 3/5/24 3Deposit growth calculated as the difference between ending deposit balances for the dates outlined using H.8 data 8 Deposits Update Quarter-to Date Trends Through 2/29 • QTD average deposits down ~$1B from 4Q24 average1 • Increases in Large Corporate & Entertainment, offset by declines in brokered CDs, TLS & Middle Market + ~$500MM increase in average interest bearing which includes a ~$500MM average decline in brokered CDs - ~$1.5B decrease in average noninterest bearing • NIB average deposit mix 40% QTD; average loan to deposit ratio of 79% • 1Q24 Outlook2: Expect average balances in line with prior 1Q guidance range Normal deposit seasonality; retain competitive advantage with favorable NIB mix Deposit Trends ($ in billions; Average) Noninterest-bearing % of Total Deposits (Avg; percentages; 4Q23) 67.8 64.3 65.9 66.0 65.1 30.0 40.0 50.0 60.0 70.0 1Q23 2Q23 3Q23 4Q23 1Q24 Thru 2/29 18 21 22 22 25 26 26 28 30 31 34 35 36 42 W B S H B A N C FG K EY SN V FI TB FH N B O K F M TB W A L R F ZI O N C FR C M A Peer Average 2.21% 1.04% -0.48% CMA All Commercial Banks Large Commercial Banks Deposit Growth3 (period-end; 2/14/24 vs. 5/31/23)

Interest Rate Sensitivity Largely achieved strategic objective to protect earnings from rate volatility 2/29/24 1Outlook as of 3/5/24 2For methodology see Company’s Form 10-K, as filed with the SEC. Estimates are based on simulation modeling analysis from our base case which utilizes a static balance sheet as of 12/31/23 9©2024, Comerica Inc. All rights reserved. • >33% increase to FY22 NII over FY21 (including PPP) • 4 - 5% increase in 4Q22 over 3Q22 (including PPP) Management Outlook for Net Interest Inc me1 • 1Q24 Outlook: Expect net interest income in line w th prior 1Q guidanc range excluding volatility from BSBY cessation • BSBY cessation & re-designation expected to create continued volatility Estimated 12-Month Net Interest Income Impact Relative to Baseline 100 bps gradual decrease $23MM 100 bps gradual decrease & 60% incremental beta $44MM 100 bps gradual increase -$36MM 100 bps gradual increase & 60% incremental beta -$65MM Sensitivity Analysis as of 12/31/23 Rates UP Rates DOWN Loan Balances Modest increase Modest decrease Deposit Balances Moderate decrease Moderate increase Deposit Beta ~48% per incremental change Securities Portfolio Partial reinvestment of cash flows Hedging (Swaps) No additions modeled 12/31/23 Model Assumptions2 100 bps (50 bps avg) gradual, non-parallel rise 22.9 23.7 23.5 23.5 23.6 23.4 23.3 22.9 22.4 2.43% 2.47% 2.49% 2.51% 2.54% 2.55% 2.55% 2.57% 2.61% 4Q23 1Q24 2Q24 3Q24 4Q24 1Q25 2Q25 3Q25 4Q25 10©2024, Comerica Inc. All rights reserved. Net Interest Income Expected Securities Repayments & Maturities2 ($ in millions) 440 650 625 625 520 575 650 545 1.71 1.41 1.54 1.39 1.42 1.50 1.44 1.48 1Q24 2Q24 3Q24 4Q24 1Q25 2Q35 3Q25 4Q25 Contractual Swap Notionals as of 12/31/231 ($ in billions; average; weighted average yield) Swap & securities attrition expected to create tailwind into 2025 Project 14 bps point to point higher yield & $1.3B lower notional from 1Q24 to 4Q25; lessens pressure on NII Deployment of liquidity from repayment of lower yielding securities expected to benefit NII Modest treasury reinvestment for collateral maintenance 12/31/23 1Received fix/pay floating swaps; maturities extend through 3Q30; Table reflects the ultimate swaps average notional balances & weighted average yields post CME LIBOR transition for terms of current & forward starting swaps currently under contract & assumes no future termination 2Outlook as of 3/5/24

(2.1) (2.2) (2.8) (2.0) (0.6) (1.0) (1.3) (0.6) (0.5) (0.5) (0.5) (0.4) 1Q23 2Q23 3Q23 4Q23 Securities Swaps Pension 4.62% 6.30% 3Q23 4Q23 Tangible Common Equity Ratio Capital Management Maintained capital position above target CET1 of ~10% 12/31/23 1Considers AOCI for securities & pension & related RWA benefit utilizing 12/31/23 risk weighting. Does not assume other potential Basel III Endgame impacts (such as market risk, operational risk & changes to standard counter-party risk). 2Refer to reconciliation of non-GAAP financial measures in appendix 3Represents the impact of $3.0B in AOCI on common equity and $2.3B in corresponding impacts to total assets 10.80% 11.09% 7.0% 3Q23 4Q23 CET1 Tier 1 11.30% 11.60% 8.5% 3Q23 4Q23 Regulatory Minimum + Capital Conservation Buffer (CCB) 11©2024, Comerica Inc. All rights reserved. 4.6 6.0 3Q23 4Q23 Common Equity Common Equity ($ in billions; period-end) Tangible Common Equity Ratio2 5.34% 7.00% 3Q23 4Q23 Common Equity Ratio Common Equity Ratio Accumulated Other Comprehensive Income ($ in billions) Scenarios Est. AOCI Increase / (Decrease) Rate shock + 100 bps Static balances ($1.4B) Rates shock - 100 bps Static balances $1.4B Estimated Change in AOCI Derived Simulated Sensitivity Analysis for Securities & Swap Portfolios 4Q23: AOCI impact3 of (328 bps) AOCI impact3 of (332 bps) AOCI impact of ($3.0) Basel III Endgame Capital Considerations We are not subject to these proposed rules with ~$86B in assets as of 12/31/23. If subject to proposed Basel III Endgame capital requirements relating to AOCI opt-out changes, our estimated CET1 would exceed regulatory minimums & conservation buffer as of 12/31/231. 7.93% Estimated CET1 with AOCI opt-out Long-standing, trust- based customer relationships, averaging >15 years in Middle Market Tenured, expert relationship & group managers with average 10 & 20 years at Comerica, respectively Consistent, disciplined credit underwriting standards & a “through- the-cycle” mindset Diversified business mix with attractive, growth & relationship-oriented business lines like Middle Market, Environmental Services & Small Business Complimentary marketing services to help small businesses grow Distinctive Treasury Solutions used for ~95% of Commercial noninterest- bearing deposits Complementary Capital Markets business Differentiated Wealth Management business specializing in the needs of business owners and executives, used by 39% of Commercial clients1 Largest third-party fiduciary business in the country with Advisor Solutions serving some of the country’s largest Broker Dealers in Estate Settlement; Oil, Gas & Mineral Management; Special Needs Trusts & Philanthropic Deep, sticky operating accounts with our C&I customers driving a 78% loan-to-deposit ratio, below our 15-year average Expert bankers serving tenured customer relationships with average customer deposit balance exceeding industry Growing small business segment of deposit rich relationships (97% have a deposit relationship) Lean, modern technology architecture & delivery model, including our “digital factory” ~75% of our business applications are Cloud & SAAS based Investment spend focused only on areas of true competitive advantage Modernization journey to transform retail delivery to optimize experience & efficiency Taking incremental actions to enhance efficiencies ©2024, Comerica Inc. All rights reserved. Our Differentiated Value Proposition A Leading Bank for Business complemented by strong Retail & Wealth Management Distinctive Commercial Franchise Complementary fee & relationship products Robust, low-cost deposit base Efficient technology & operations 12/31/23 1As of 9/30/23 12

Primary Markets Other Markets Office Locations Diversified Geographic Footprint Texas • Established: 1988 • #2 largest state GDP • Business friendly environment • Dallas-Fort Worth, Houston, Austin, San Antonio California • Established: 1991 • #1 largest state GDP • Deep industry expertise • L.A., San Diego, San Jose, San Francisco Michigan • Established: 1849 • #14 largest state GDP • Large retail deposit base • Detroit, Ann Arbor, Grand Rapids, Lansing Offices Across U.S. Southeast • Strong population growth & manufacturing base • 3 commercial offices in Raleigh, Winston-Salem & Charlotte • New offices in SC & GA • Serving customers in FL, GA, NC, TN, SC & VA Mountain West • Fast growing economy, attractive climate • 1 office in Denver • Serving customers in AZ & CO 13©2024, Comerica Inc. All rights reserved. Large, higher growth urban markets Highly integrated, cost-effective platformPredominance of middle market companies & wealth management opportunities 1Average 4Q23 loans 2Average 4Q23 deposits 3Other Markets includes FL, AZ, International Finance Division & businesses that have a significant presence outside of the three primary geographic markets 35% 25% 14% 26% MI CA TX Other Markets 23% 36% 24% 18% MI CA TX Other Markets Loans1 Deposits2 3 3 (millions, except per share data) 2023 2022 Change Average loans $53,903 $50,460 $3,443 Average deposits 66,018 75,481 (9,463) Net interest income 2,514 2,466 48 Provision for credit losses 89 60 29 Noninterest income1 1,078 1,068 10 Noninterest expenses1 2,359 1,998 361 Provision for income tax 263 325 (62) Net income 881 1,151 (270) Earnings per share2 $6.44 $8.47 $(2.03) Efficiency Ratio 66% 56% Return on Average Equity3 16.50% 18.63% Return on Average Assets 1.01% 1.32% FY23 compared to FY22 1Includes gains/(losses) related to deferred comp plan of $13MM FY23 & $(18)MM FY22 2Diluted earnings per common share 3Return on common shareholders’ equity Key Performance Drivers Year over Year • Loans up $3.4B or 7% driven by growth in Commercial Real Estate & National Dealer Services, partially offset by loan optimization 2H23 including exit of Mortgage Banker • Deposits impacted by diversification efforts related to industry disruption; stabilization & successful deposit recapture strategy in 2H23 • Record net interest income benefitted from higher rates offsetting impact of deposit & borrowing costs • Credit quality remained very strong with net charge offs of 4 bps • Noninterest income impacted by BSBY cessation, offsetting positive trends in noncustomer & customer fee income • Expenses reflect FDIC special assessment, investment- related pressures & costs associated with initiatives to enhance future earnings power FY23 Results Record average loan balances & net interest income; excellent credit quality ©2024, Comerica Inc. All rights reserved. 14

Notable 4Q23 Items Subject1 4Q23 Accounting Impact (pre-tax) 4Q23 EPS Impact (net of tax) FDIC special assessment2 +$109MM noninterest expense ($0.62) Impact of BSBY cessation announcement -$91MM other noninterest income +$3MM net interest income =$88MM net non-cash, pre-tax impact Note: The impact of this accounting change will accrete back over time. ($0.52) Expense re-calibration initiatives +$25MM noninterest expense ($0.14) Ameriprise partnership accounting -$2MM noninterest income $2MM fiduciary income $2MM other noninterest income + $2MM net increase in brokerage fees -$2MM noninterest expense None Additional Item (no bottom-line impact): 1See slide 21 for descriptions of notable items 2See page F-7 of Company’s Form 10-K, as filed with the SEC, for updated information as of February 2024. ©2024, Comerica Inc. All rights reserved. 15 4Q23 Results Impacted by notable items; strategic balance sheet management intended to support future growth 1Includes gains/(losses) related to deferred comp asset returns of $6MM 4Q22, ($3MM) 3Q23, $8MM 4Q23 2Diluted earnings per common share 3Noninterest expenses as a percentage of the sum of net interest income and noninterest income excluding net gains (losses) from securities, a derivative contract tied to the conversion rate of Visa Class B shares and changes in the value of shares obtained through monetization of warrants (millions, except per share data) 4Q23 3Q23 4Q22 Change From 3Q23 4Q22 Average loans $52,796 $53,987 $52,375 $(1,191) $421 Average deposits 66,045 65,883 71,355 162 (5,310) Net interest income 584 601 742 (17) (158) Provision for credit losses 12 14 33 (2) (21) Noninterest income1 198 295 278 (97) (80) Noninterest expenses1 718 555 541 163 177 Provision for income tax 19 76 96 (57) (77) Net income 33 251 350 (218) (317) Earnings per share2 $0.20 $1.84 $2.58 $(1.64) $(2.38) Efficiency Ratio3 91.86% 61.86% 53.00% CET1 11.09% 10.80% 10.00% Key Performance Drivers 4Q23 compared to 3Q23 • Average loans declined 2.2% with the exit of Mortgage Banker Finance & continued selectivity prioritizing returns • Deposits remained stable despite impact from Mortgage Banker Finance exit • Net interest income impacted by lower excess cash, strategic management of loans & successful growth in interest bearing deposits • Modest net charge-offs of 15 bps; reserve ratio rose to 1.40% reflecting market normalization • Noninterest income impacted largely by BSBY cessation; investment in customer-related fee income remains a priority • Noninterest expense impacted by special FDIC assessment & actions taken to enhance future earnings power • Strong CET1 continued to grow above our 10% strategic target despite notable items 16©2024, Comerica Inc. All rights reserved.

-4.1 -3.8 CMA Peer Avg. Noninterest-bearing Deposit Change (Avg.; percentages; 4Q23 vs 3Q23) Interest-bearing Deposit Change (Avg.; percentages; 4Q23 vs 3Q23) 3.7 3.1 CMA Peer Avg. CMA vs Peers 4Q23 Source for peer data: S&P Global Market Intelligence & company press releases Interest-Bearing Deposit Cost (percentages; FY23) 17©2024, Comerica Inc. All rights reserved. Noninterest-bearing % of Total Deposits (Avg; percentages; 4Q23) Total Deposit Change (Avg; percentages; 4Q23 vs 3Q23) 0.2 1.0 CMA Peer Avg. 2.52 2.41 CMA Peer Avg. 6.8 7.0 CMA Peer Avg. Full Year Loan Growth (Avg.; percentages; FY23 vs FY22) Loan to Deposit Ratio (Period-end; percentages; 4Q23) Loan Yield (percentages; 4Q23) 6.38 6.26 CMA Peer Avg. 18 21 22 22 25 26 26 28 30 31 34 35 36 42 W B S H B A N C FG K EY SN V FI TB FH N B O K F M TB W A L R F ZI O N C FR C M A Peer Average 45 69 70 77 77 77 78 81 82 82 83 86 91 93 C FR FI TB B O K F R F ZI O N K EY C M A H B A N M TB C FG W B S SN V W A L FH N Peer Average 52.4 53.5 55.4 54.0 52.8 53.4 52.1 5.45 5.89 6.18 6.34 6.38 4Q22 1Q23 2Q23 3Q23 4Q23 3Q23 4Q23 Loans Strategic optimization efforts prioritized relationships; positioned for enhanced returns & growth 4Q23 compared to 3Q23 1See Quarterly Average Loans slide for more details 2See Commercial Real Estate slide for more details Loans ($ in billions) Average loans decreased $1.2B1, or 2.2% - $543MM Mortgage Banker (strategic exit) - $433MM General Middle Market - $361MM Equity Fund Services - $336MM Corporate Banking + $377MM Commercial Real Estate2 + $284MM National Dealer Services 18©2024, Comerica Inc. All rights reserved. Loan Yields % Average Balances Period-end 56.5 57.5 57.0 55.5 53.7 45% 46% 47% 47% 48% 4Q22 1Q23 2Q23 3Q23 4Q23 Utilization Loan Commitments Declined with Increased Selectivity (period-end: $ in billions)

71.4 67.8 64.3 65.9 66.0 0.97 1.52 2.37 2.90 3.12 4Q22 1Q23 2Q23 3Q23 4Q23 Deposits Trends reflect stability & strong customer relationships 4Q23 compared to 3Q23 1Interest costs on interest-bearing deposits 2Deposit growth calculated as the difference between ending deposit balances for the dates outlined using H.8 data Deposits ($ in billions) Deposit Rate1 % Average Balances Average deposits increased $0.2B, or 0.2% + $614MM General Middle Market + $240MM Retail Bank + $198MM Corporate Banking - $564MM brokered time deposits - $176MM Mortgage Banker Finance (strategic exit) - $129MM National Dealer Services • Interest-bearing increase of $1.4B; Noninterest-bearing decline of $1.2B • Cumulative interest-bearing deposit beta of 58% • 4Q23 average NIB at 42% of total deposits, impacted by success in growing interest-bearing deposits; NIB balances trending in line with expectation 19©2024, Comerica Inc. All rights reserved. Favorable Mix (period-end,$ in billions) 67.2 66.8 3Q23 4Q23 45% 42% NIB IB 7.39% 1.74% 1.14% CMA All Commercial Banks Large Commercial Banks Deposit Growth2 (period-end; 12/27/23 vs. 5/31/23) 4Q23 compared to 3Q23 1Represents uninsured deposits using total deposits at the consolidated level for Comerica Inc. & subsidiaries, which is consistent with the presentation on the consolidated balance sheet, & excludes uninsured deposits eliminated in consolidation 212/31/23 is estimated 3As of 12/31/23 4Includes consumer & small business ©2024, Comerica Inc. All rights reserved. Attractive Deposit Profile Further enhanced our strong deposit franchise Deposit portfolio has better risk characteristics • Less concentrated in more vulnerable businesses • Lower price sensitivity • Lower percent of uninsured & excess deposits • Retained strong mix of 42% noninterest-bearing Stronger Profile than Pre-Pandemic ($ in billions) YE 2019 YE 2022 12/31/2023 Loan-to-Deposit Ratio 88% 75% 78% Total Deposits (Period-end) $57.3 $71.4 $66.8 % Uninsured Deposits Per Call Report Adjusted for Affiliate Deposits1 60% 54% 64% 57% 47%2 41%2 Stable & Tenured Core Deposit Base3 Diversified Across Markets & Businesses • Highest concentrations in Retail Consumer (28%), Middle Market Lending (12%) & Small Business Banking (8%), inherently diversified business lines • Geographically dispersed Holistic, Connected Relationships • ~95% of Commercial Bank noninterest-bearing deposits utilize Treasury Management services; ~91% have ECA • Average Middle Market relationship has >7 Treasury Management products • ~90% Retail customers have checking account4 Tenured • Average Middle Market relationship >15 years • Average Retail relationship >15 years4 Active Operating Accounts • Average Middle Market relationship deposit balances of ~$8MM (includes ~$2MM in non-interest bearing) • Average Retail customer checking account balance of $27.7K4 Commercial Bank 49%Retail Bank 37% Wealth Management 6% Other 8% Diversified Deposit Base (4Q23 average) 20